CN106573076A - pH响应聚合物库及其纳米探针 - Google Patents

pH响应聚合物库及其纳米探针 Download PDF

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Publication number
CN106573076A
CN106573076A CN201580042073.XA CN201580042073A CN106573076A CN 106573076 A CN106573076 A CN 106573076A CN 201580042073 A CN201580042073 A CN 201580042073A CN 106573076 A CN106573076 A CN 106573076A
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polymer
alkyl
peo
methods
hydrogen
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Chinese (zh)
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高进明
黄钢
赵天
马鑫鹏
王光
王一光
李阳
巴朗·D·苏梅尔
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University of Texas System
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University of Texas System
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
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    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
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    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
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    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
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    • C08F8/00—Chemical modification by after-treatment
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    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Graft Or Block Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
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CN201580042073.XA 2014-06-06 2015-06-05 pH响应聚合物库及其纳米探针 Pending CN106573076A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462009019P 2014-06-06 2014-06-06
US62/009,019 2014-06-06
PCT/US2015/034575 WO2015188157A1 (en) 2014-06-06 2015-06-05 Library of ph responsive polymers and nanoprobes thereof

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US (4) US10098971B2 (enExample)
EP (1) EP3151867A4 (enExample)
JP (1) JP6598161B2 (enExample)
KR (1) KR20170029430A (enExample)
CN (1) CN106573076A (enExample)
AU (1) AU2015269068A1 (enExample)
CA (1) CA2951180A1 (enExample)
IL (1) IL249363A0 (enExample)
MX (1) MX2016016135A (enExample)
SG (1) SG11201610180YA (enExample)
WO (1) WO2015188157A1 (enExample)

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CN107389636A (zh) * 2017-07-13 2017-11-24 湖南科技大学 一种可在癌细胞中检测内源性谷胱甘肽的水溶性荧光传感器的制备及应用
CN110201189A (zh) * 2019-06-03 2019-09-06 沈阳药科大学 白蛋白结合型近红外荧光染料-马来酰亚胺共轭物
CN110856750A (zh) * 2018-08-16 2020-03-03 北京大学 pH敏感缀合物、胶束及其制备方法和用途
CN111154118A (zh) * 2020-01-19 2020-05-15 浙江理工大学 一种具有不同长径比的单晶聚合物胶束及其制备方法
CN113039248A (zh) * 2018-09-15 2021-06-25 德克萨斯大学系统董事会 用于肿瘤酸中毒成像的双模式ups纳米探针
CN114144399A (zh) * 2019-05-28 2022-03-04 德克萨斯大学系统董事会 pH响应性组合物及其用途
CN115279422A (zh) * 2019-11-18 2022-11-01 昂科纳诺医药公司 pH响应性组合物、调配物和对肿瘤成像的方法
CN115279353A (zh) * 2019-11-04 2022-11-01 昂科纳诺医药公司 pH响应性嵌段共聚物组合物、胶束和使用方法
CN115337398A (zh) * 2022-09-07 2022-11-15 大连理工大学 一种atp响应的用于肿瘤化疗与光动力联合治疗的纳米药物及其制备方法
CN115785346A (zh) * 2022-01-20 2023-03-14 北京大学 含非pH敏感型单体的pH敏感聚合物的合成及应用

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AU2015269068A1 (en) * 2014-06-06 2016-12-22 The Board Of Regents Of The University Of Texas System Library of pH responsive polymers and nanoprobes thereof
AU2017225769B2 (en) * 2016-03-02 2023-01-05 The Board Of Regents Of The University Of Texas System Sting activating nanovaccine for immunotherapy
US20200333357A1 (en) * 2017-11-13 2020-10-22 The Board Of Regents Of The University Of Texas System Novel tfeb pathway agonists for metabolic diseases and ageing
WO2019126144A1 (en) * 2017-12-22 2019-06-27 North Carolina State University Polymeric fluorophores, compositions comprising the same, and methods of preparing and using the same
BR102018007667A2 (pt) * 2018-04-16 2019-10-29 Mendes Alves Pereira Ricardo dispositivo, sistema e processo de armazenamento de dados clínicos-cirúrgicos
JP7676331B2 (ja) * 2019-06-22 2025-05-14 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 生分解性超ｐＨ感受性ポリマー
CN110272539B (zh) * 2019-07-04 2021-09-17 广东工业大学 一种用于结合pmsa的配体缀合物、探针及其制备方法和应用
CN110551263B (zh) * 2019-09-05 2021-09-24 华南师范大学 一种多嵌段聚合物及其合成方法和肿瘤检测用荧光探针
US11928193B2 (en) 2019-12-10 2024-03-12 Winkk, Inc. Multi-factor authentication using behavior and machine learning
CN111159932B (zh) * 2019-12-10 2022-09-27 中国船舶重工集团公司第七一九研究所 一种针对Mullins效应参数的优化反演方法
EP4162445A4 (en) * 2020-06-09 2024-07-10 Temasek Life Sciences Laboratory Limited AUTOMATED DISEASE DETECTION SYSTEM
CN113916844A (zh) * 2020-07-08 2022-01-11 长春工业大学 一种蓝红光双发射纳米杂化探针的制备方法及其在离子检测中的应用
US20250127921A1 (en) * 2021-08-10 2025-04-24 Wisconsin Alumni Research Foundation Ph-responsive nano particle for delivery of ribonucleoproteins

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CN115337398A (zh) * 2022-09-07 2022-11-15 大连理工大学 一种atp响应的用于肿瘤化疗与光动力联合治疗的纳米药物及其制备方法

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