CN106565751B - 注射用头孢西丁钠粉针制剂的制备方法 - Google Patents
注射用头孢西丁钠粉针制剂的制备方法 Download PDFInfo
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- CN106565751B CN106565751B CN201610871528.5A CN201610871528A CN106565751B CN 106565751 B CN106565751 B CN 106565751B CN 201610871528 A CN201610871528 A CN 201610871528A CN 106565751 B CN106565751 B CN 106565751B
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- cefoxitin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610871528.5A CN106565751B (zh) | 2016-09-30 | 2016-09-30 | 注射用头孢西丁钠粉针制剂的制备方法 |
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CN201610871528.5A CN106565751B (zh) | 2016-09-30 | 2016-09-30 | 注射用头孢西丁钠粉针制剂的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN106565751A CN106565751A (zh) | 2017-04-19 |
CN106565751B true CN106565751B (zh) | 2018-11-06 |
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CN201610871528.5A Active CN106565751B (zh) | 2016-09-30 | 2016-09-30 | 注射用头孢西丁钠粉针制剂的制备方法 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101941982A (zh) * | 2009-11-24 | 2011-01-12 | 中国医药集团总公司四川抗菌素工业研究所 | 药用头孢雷特的制备新方法 |
CN102399234A (zh) * | 2011-12-06 | 2012-04-04 | 苏州中联化学制药有限公司 | 头孢西丁钠的制备方法 |
CN104513256A (zh) * | 2013-10-07 | 2015-04-15 | 鲁南贝特制药有限公司 | 一种头孢妥仑匹酯的制备方法 |
CN104622695A (zh) * | 2015-03-10 | 2015-05-20 | 华北制药河北华民药业有限责任公司 | 一种注射用头孢西丁钠粉针制剂 |
CN105315300A (zh) * | 2014-05-26 | 2016-02-10 | 海口市制药厂有限公司 | 一种头孢西丁钠、其制备方法及用途 |
-
2016
- 2016-09-30 CN CN201610871528.5A patent/CN106565751B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101941982A (zh) * | 2009-11-24 | 2011-01-12 | 中国医药集团总公司四川抗菌素工业研究所 | 药用头孢雷特的制备新方法 |
CN102399234A (zh) * | 2011-12-06 | 2012-04-04 | 苏州中联化学制药有限公司 | 头孢西丁钠的制备方法 |
CN104513256A (zh) * | 2013-10-07 | 2015-04-15 | 鲁南贝特制药有限公司 | 一种头孢妥仑匹酯的制备方法 |
CN105315300A (zh) * | 2014-05-26 | 2016-02-10 | 海口市制药厂有限公司 | 一种头孢西丁钠、其制备方法及用途 |
CN104622695A (zh) * | 2015-03-10 | 2015-05-20 | 华北制药河北华民药业有限责任公司 | 一种注射用头孢西丁钠粉针制剂 |
Non-Patent Citations (2)
Title |
---|
头孢西丁钠稳定性改进;魏青杰;《河北化工》;20111031;第34卷(第10期);14-15 * |
头孢西丁钠结晶工艺改进;魏青杰,等;《广州化工》;20111231;第39卷(第21期);102-103 * |
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CN106565751A (zh) | 2017-04-19 |
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Inventor after: Zhang Suoqing Inventor after: Du Jinsong Inventor after: Zheng Baoli Inventor after: Men Hongle Inventor after: Hu Limin Inventor after: Zhou Xiaobing Inventor after: Sun Yan Inventor after: Yang Mengde Inventor after: Liu Shiping Inventor after: Liu Haixi Inventor after: Liu Xuefei Inventor after: Jia Yujie Inventor before: Zhang Suoqing Inventor before: Men Hongle Inventor before: Hu Limin Inventor before: Yang Mengde Inventor before: Liu Shiping Inventor before: Liu Haixi Inventor before: Liu Xuefei Inventor before: Jia Yujie Inventor before: Du Jinsong Inventor before: Zheng Baoli |