CN106459153B - 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法 - Google Patents

蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法 Download PDF

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CN106459153B
CN106459153B CN201580016781.6A CN201580016781A CN106459153B CN 106459153 B CN106459153 B CN 106459153B CN 201580016781 A CN201580016781 A CN 201580016781A CN 106459153 B CN106459153 B CN 106459153B
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amino acid
acid sequence
antibody
isolated polypeptide
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CN106459153A (zh
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S.J.穆尔
M.T.L.阮
D.R.霍斯特特
O.瓦西列瓦
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Cytomx Therapeutics Inc
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CN201580016781.6A 2014-01-31 2015-01-30 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法 Active CN106459153B (zh)

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PCT/US2015/013776 WO2015116933A2 (en) 2014-01-31 2015-01-30 Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof

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US11932697B2 (en) 2016-11-28 2024-03-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding domain, and polypeptide including conveying section
US12060654B2 (en) 2016-11-28 2024-08-13 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand binding activity

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IL291329B1 (en) 2013-09-25 2025-09-01 Cytomx Therapeutics Inc Polypeptides that can be determined in matrix metalloproteinases and uses thereof
CN106459153B (zh) 2014-01-31 2021-12-21 西托姆克斯治疗公司 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法
WO2016014974A2 (en) 2014-07-25 2016-01-28 Cytomx Therapeutics, Inc. Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
US11400157B2 (en) 2015-05-13 2022-08-02 Chugai Seiyaku Kabushiki Kaisha Multiple antigen binding molecular fusion, pharmaceutical composition, method for identifying linear epitope, and method for preparing multiple antigen binding molecular fusion
BR102016018074A2 (pt) * 2015-08-07 2021-11-16 ALX Oncology Inc. Construção variante de sirp-alfa, seu método de preparação e seus usos, molécula de ácido nucleico, vetor, célula hospedeira, e composição farmacêutica
JP6898303B2 (ja) 2015-08-07 2021-07-07 エーエルエックス オンコロジー インコーポレイテッド Ｓｉｒｐ−アルファドメインまたはそのバリアントを有する構築物
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
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AU2016358296B2 (en) 2015-11-19 2020-05-21 Revitope Limited Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells
CN108697798A (zh) * 2016-02-16 2018-10-23 达纳-法伯癌症研究所有限公司 免疫疗法组合物及方法
CN110036034A (zh) 2016-12-09 2019-07-19 西雅图遗传学公司 卷曲螺旋掩蔽的二价抗体
MY200973A (en) 2017-04-11 2024-01-26 Inhibrx Inc Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same
CN108690138A (zh) * 2017-04-12 2018-10-23 鸿运华宁（杭州）生物医药有限公司 一种能与人cd19或cd20和人cd3结合的双特异性抗体及其应用
MX2019013648A (es) 2017-05-19 2021-01-08 Wuxi Biologics Shanghai Co Ltd Anticuerpos monoclonales novedosos para proteina 4 asociada con el linfocito t citotoxico (ctla-4).
US11623965B2 (en) 2017-08-16 2023-04-11 Bristol-Myers Squibb Company Prodruggable antibodies, prodrugs thereof, and methods of use and making
IL321773A (en) 2017-10-14 2025-08-01 Cytomx Therapeutics Inc Activatable antibodies and methods for preparing them
US11530433B2 (en) * 2017-10-20 2022-12-20 President And Fellows Of Harvard College Artificial secretion peptides for heterologous protein production
WO2019107384A1 (ja) * 2017-11-28 2019-06-06 中外製薬株式会社 リガンド結合活性が調整可能なリガンド結合分子
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