JP6835586B2 - マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法 - Google Patents

マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法 Download PDF

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JP6835586B2
JP6835586B2 JP2016549123A JP2016549123A JP6835586B2 JP 6835586 B2 JP6835586 B2 JP 6835586B2 JP 2016549123 A JP2016549123 A JP 2016549123A JP 2016549123 A JP2016549123 A JP 2016549123A JP 6835586 B2 JP6835586 B2 JP 6835586B2
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JP2017509594A5 (enExample
JP2017509594A (ja
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ジェイムズ ムーア スティーブン
ジェイムズ ムーア スティーブン
ティー ルー グエン マーガレット
ティー ルー グエン マーガレット
アール．ホステッター ダニエル
アール．ホステッター ダニエル
バジルジェバ オルガ
バジルジェバ オルガ
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シトムクス セラピューティクス，インコーポレイティド
シトムクス セラピューティクス，インコーポレイティド
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
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JP2016549123A 2014-01-31 2015-01-30 マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法 Active JP6835586B2 (ja)

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JP2021016630A JP7337864B2 (ja) 2014-01-31 2021-02-04 マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法
JP2023134791A JP2023159314A (ja) 2014-01-31 2023-08-22 マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法

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US201461934619P 2014-01-31 2014-01-31
US61/934,619 2014-01-31
US201461971009P 2014-03-27 2014-03-27
US61/971,009 2014-03-27
PCT/US2015/013776 WO2015116933A2 (en) 2014-01-31 2015-01-30 Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof

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JP2017509594A5 JP2017509594A5 (enExample) 2018-03-08
JP6835586B2 true JP6835586B2 (ja) 2021-02-24

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JP2021016630A Active JP7337864B2 (ja) 2014-01-31 2021-02-04 マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法
JP2023134791A Pending JP2023159314A (ja) 2014-01-31 2023-08-22 マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法

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JP2023134791A Pending JP2023159314A (ja) 2014-01-31 2023-08-22 マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法

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KR (1) KR102466591B1 (enExample)
CN (2) CN106459153B (enExample)
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BR (1) BR112016017649B1 (enExample)
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JP2021072848A (ja) * 2014-01-31 2021-05-13 シトムクス セラピューティクス，インコーポレイティド マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法

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WO2016014974A2 (en) 2014-07-25 2016-01-28 Cytomx Therapeutics, Inc. Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
IL300408B2 (en) 2015-01-20 2025-11-01 Cytomx Therapeutics Inc Matrix metalloprotease-cleavable and serine protease cleavable substrates and methods of use thereof
JP6841754B2 (ja) 2015-05-13 2021-03-10 中外製薬株式会社 多重抗原結合分子融合体、医薬組成物、線状エピトープの同定方法、および多重抗原結合分子融合体の製造方法
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