CN106458929A - N‑(氰基甲基)‑4‑(2‑(4‑吗啉代苯基氨基)嘧啶‑4‑基)苯甲酰胺盐酸盐 - Google Patents

N‑(氰基甲基)‑4‑(2‑(4‑吗啉代苯基氨基)嘧啶‑4‑基)苯甲酰胺盐酸盐 Download PDF

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Publication number
CN106458929A
CN106458929A CN201580031169.6A CN201580031169A CN106458929A CN 106458929 A CN106458929 A CN 106458929A CN 201580031169 A CN201580031169 A CN 201580031169A CN 106458929 A CN106458929 A CN 106458929A
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China
Prior art keywords
cyt
cyanomethyl
pyrimidin
morpholinophenylamino
benzamide
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Pending
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CN201580031169.6A
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English (en)
Chinese (zh)
Inventor
B.H.布朗
E.A.卡拉
J.N.海明威
H.莫里森
T.雷诺兹
B.史
D.斯蒂芬尼迪斯
F.王
M.R.瓦尔
J.A.惠特尼
Y.辛
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Gilead Sciences Inc
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Gilead Sciences Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53674249&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN106458929(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Priority to CN201910920874.1A priority Critical patent/CN110627728A/zh
Publication of CN106458929A publication Critical patent/CN106458929A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201580031169.6A 2014-06-12 2015-06-11 N‑(氰基甲基)‑4‑(2‑(4‑吗啉代苯基氨基)嘧啶‑4‑基)苯甲酰胺盐酸盐 Pending CN106458929A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910920874.1A CN110627728A (zh) 2014-06-12 2015-06-11 N-(氰基甲基)-4-(2-(4-吗啉代苯基氨基)嘧啶-4-基)苯甲酰胺盐酸盐

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011315P 2014-06-12 2014-06-12
US62/011,315 2014-06-12
PCT/US2015/035316 WO2015191846A1 (en) 2014-06-12 2015-06-11 N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts

Related Child Applications (1)

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CN201910920874.1A Division CN110627728A (zh) 2014-06-12 2015-06-11 N-(氰基甲基)-4-(2-(4-吗啉代苯基氨基)嘧啶-4-基)苯甲酰胺盐酸盐

Publications (1)

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CN201580031169.6A Pending CN106458929A (zh) 2014-06-12 2015-06-11 N‑(氰基甲基)‑4‑(2‑(4‑吗啉代苯基氨基)嘧啶‑4‑基)苯甲酰胺盐酸盐
CN201910920874.1A Pending CN110627728A (zh) 2014-06-12 2015-06-11 N-(氰基甲基)-4-(2-(4-吗啉代苯基氨基)嘧啶-4-基)苯甲酰胺盐酸盐

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106316963B (zh) * 2015-06-26 2021-06-08 苏州泽璟生物制药股份有限公司 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物
CN115957221A (zh) * 2021-10-09 2023-04-14 广东东阳光药业有限公司 抗纤维化组合物

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TWI681954B (zh) * 2014-06-12 2020-01-11 美商西爾拉癌症醫學公司 Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺
CN106316964B (zh) * 2015-06-26 2019-06-25 苏州泽璟生物制药股份有限公司 苯基氨基嘧啶化合物或其盐的多晶型物
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN106316963B (zh) * 2015-06-26 2021-06-08 苏州泽璟生物制药股份有限公司 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物
CN115957221A (zh) * 2021-10-09 2023-04-14 广东东阳光药业有限公司 抗纤维化组合物
CN115957221B (zh) * 2021-10-09 2026-01-06 广东东阳光药业股份有限公司 抗纤维化组合物

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WO2015191846A1 (en) 2015-12-17
SG11201610079VA (en) 2016-12-29
FR24C1030I2 (fr) 2025-06-13
EA201692356A1 (ru) 2017-07-31
JP2021107465A (ja) 2021-07-29
AU2015274554B2 (en) 2018-02-15
NZ725966A (en) 2018-04-27
TW202012378A (zh) 2020-04-01
JP6600649B2 (ja) 2019-10-30
BR112016028749A2 (pt) 2017-08-22
JP7198867B2 (ja) 2023-01-04
IL276948A (en) 2020-10-29
MA40067A (fr) 2015-12-17
HUE051360T2 (hu) 2021-03-01
AU2015274554B9 (en) 2018-04-19
USRE50497E1 (en) 2025-07-22
JP6840909B2 (ja) 2021-03-10
CY2024024I1 (el) 2025-03-28
CU20160183A7 (es) 2017-05-10
ECSP16093323A (es) 2017-01-31
US9809559B2 (en) 2017-11-07
SG10201911925TA (en) 2020-01-30
EP3907219A1 (en) 2021-11-10
CY2024024I2 (el) 2025-03-28
NL301282I2 (nl) 2025-03-12
JP2017517535A (ja) 2017-06-29
TWI681954B (zh) 2020-01-11
TW202134236A (zh) 2021-09-16
LT3154950T (lt) 2020-11-25
FR24C1030I1 (fr) 2024-08-30
SI3154950T1 (sl) 2021-01-29
MX2019009564A (es) 2019-10-02
USRE49445E1 (en) 2023-03-07
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DK3154950T3 (da) 2020-09-14
EP3154950B1 (en) 2020-08-05
TWI729644B (zh) 2021-06-01
JP6883560B2 (ja) 2021-06-09
US20150361050A1 (en) 2015-12-17
KR101928225B1 (ko) 2018-12-11
CN110627728A (zh) 2019-12-31
TW201617323A (zh) 2016-05-16
IL249038A0 (en) 2017-01-31
CA2951883A1 (en) 2015-12-17
PT3154950T (pt) 2020-10-09
ES2822773T3 (es) 2021-05-04
JP2023021454A (ja) 2023-02-10
EA032639B1 (ru) 2019-06-28
HUS2400025I1 (hu) 2024-08-28
RS61065B1 (sr) 2020-12-31
IL249038B (en) 2020-09-30
JP2018184486A (ja) 2018-11-22
FIC20240025I1 (fi) 2024-07-12
US9469613B2 (en) 2016-10-18
LTPA2024523I1 (enExample) 2024-07-25
KR20170015496A (ko) 2017-02-08
EP3719005A1 (en) 2020-10-07
AU2015274554A1 (en) 2016-11-24
UY36166A (es) 2016-01-29
US20160347719A1 (en) 2016-12-01
PL3154950T3 (pl) 2021-01-25
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IL276948B (en) 2021-09-30
HRP20201492T1 (hr) 2021-01-08

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