CR20160575A - Sales del clorhidrato de n-(cianometil)-4-(2-(4-morfolinofenilamino) pirimidin-4-il)benzamida - Google Patents

Sales del clorhidrato de n-(cianometil)-4-(2-(4-morfolinofenilamino) pirimidin-4-il)benzamida

Info

Publication number
CR20160575A
CR20160575A CR20160575A CR20160575A CR20160575A CR 20160575 A CR20160575 A CR 20160575A CR 20160575 A CR20160575 A CR 20160575A CR 20160575 A CR20160575 A CR 20160575A CR 20160575 A CR20160575 A CR 20160575A
Authority
CR
Costa Rica
Prior art keywords
pyrimidin
morpholinophenylamine
cyanometil
benzamida
chlorhydrate
Prior art date
Application number
CR20160575A
Other languages
English (en)
Inventor
Jeffrey N Hemenway
Brandon H Brown
Henry Morrison
Dimitrios Stefandis
Fang Wang
Ernest A Carra
Troy Reynolds
Yan Xin
Bing Shi
James Andrew Whitney
Matthew Robert Warr
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53674249&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20160575(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CR20160575A publication Critical patent/CR20160575A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a formas de sales nuevas y estables de N-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida que son adecuadas para la preparación de formulaciones farmacéuticas de las mismas y su uso terapéutico.
CR20160575A 2014-06-12 2015-06-11 Sales del clorhidrato de n-(cianometil)-4-(2-(4-morfolinofenilamino) pirimidin-4-il)benzamida CR20160575A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462011315P 2014-06-12 2014-06-12
PCT/US2015/035316 WO2015191846A1 (en) 2014-06-12 2015-06-11 N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts

Publications (1)

Publication Number Publication Date
CR20160575A true CR20160575A (es) 2017-01-20

Family

ID=53674249

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160575A CR20160575A (es) 2014-06-12 2015-06-11 Sales del clorhidrato de n-(cianometil)-4-(2-(4-morfolinofenilamino) pirimidin-4-il)benzamida

Country Status (33)

Country Link
US (4) US9469613B2 (es)
EP (3) EP3719005A1 (es)
JP (5) JP6600649B2 (es)
KR (1) KR101928225B1 (es)
CN (2) CN110627728A (es)
AP (1) AP2016009551A0 (es)
AR (1) AR100818A1 (es)
AU (1) AU2015274554B9 (es)
BR (1) BR112016028749A2 (es)
CA (1) CA2951883C (es)
CR (1) CR20160575A (es)
CU (1) CU20160183A7 (es)
CY (1) CY1123604T1 (es)
DK (1) DK3154950T3 (es)
EA (1) EA032639B1 (es)
EC (1) ECSP16093323A (es)
ES (1) ES2822773T3 (es)
HR (1) HRP20201492T1 (es)
HU (1) HUE051360T2 (es)
IL (3) IL249038B (es)
LT (1) LT3154950T (es)
MA (1) MA40067A (es)
MX (3) MX2016016294A (es)
NZ (1) NZ725966A (es)
PH (1) PH12016502461A1 (es)
PL (1) PL3154950T3 (es)
PT (1) PT3154950T (es)
RS (1) RS61065B1 (es)
SG (2) SG10201911925TA (es)
SI (1) SI3154950T1 (es)
TW (3) TWI681954B (es)
UY (1) UY36166A (es)
WO (1) WO2015191846A1 (es)

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CN106316963B (zh) * 2015-06-26 2021-06-08 苏州泽璟生物制药股份有限公司 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
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Also Published As

Publication number Publication date
US9809559B2 (en) 2017-11-07
AU2015274554B2 (en) 2018-02-15
EP3719005A1 (en) 2020-10-07
LT3154950T (lt) 2020-11-25
NZ725966A (en) 2018-04-27
CA2951883C (en) 2020-05-05
IL286442A (en) 2021-10-31
JP2018184486A (ja) 2018-11-22
TWI681954B (zh) 2020-01-11
SG11201610079VA (en) 2016-12-29
BR112016028749A2 (pt) 2017-08-22
USRE49445E1 (en) 2023-03-07
JP6600649B2 (ja) 2019-10-30
HUE051360T2 (hu) 2021-03-01
EP3907219A1 (en) 2021-11-10
MX2019009564A (es) 2019-10-02
PT3154950T (pt) 2020-10-09
WO2015191846A1 (en) 2015-12-17
IL276948A (en) 2020-10-29
KR101928225B1 (ko) 2018-12-11
JP2021107465A (ja) 2021-07-29
ES2822773T3 (es) 2021-05-04
KR20170015496A (ko) 2017-02-08
JP2017517535A (ja) 2017-06-29
IL249038A0 (en) 2017-01-31
PH12016502461A1 (en) 2017-03-06
TW201617323A (zh) 2016-05-16
US20160347719A1 (en) 2016-12-01
MX2016016294A (es) 2017-09-01
ECSP16093323A (es) 2017-01-31
HRP20201492T1 (hr) 2021-01-08
EP3154950A1 (en) 2017-04-19
CN106458929A (zh) 2017-02-22
TW202134236A (zh) 2021-09-16
AR100818A1 (es) 2016-11-02
AP2016009551A0 (en) 2016-11-30
SI3154950T1 (sl) 2021-01-29
DK3154950T3 (da) 2020-09-14
JP2020059759A (ja) 2020-04-16
CN110627728A (zh) 2019-12-31
EP3154950B1 (en) 2020-08-05
UY36166A (es) 2016-01-29
JP6840909B2 (ja) 2021-03-10
IL276948B (en) 2021-09-30
AU2015274554B9 (en) 2018-04-19
US9469613B2 (en) 2016-10-18
MA40067A (fr) 2015-12-17
RS61065B1 (sr) 2020-12-31
CU20160183A7 (es) 2017-05-10
JP6883560B2 (ja) 2021-06-09
CY1123604T1 (el) 2022-03-24
AU2015274554A1 (en) 2016-11-24
TWI729644B (zh) 2021-06-01
EA032639B1 (ru) 2019-06-28
PL3154950T3 (pl) 2021-01-25
EA201692356A1 (ru) 2017-07-31
TW202012378A (zh) 2020-04-01
MX2022015558A (es) 2023-01-30
IL249038B (en) 2020-09-30
USRE48285E1 (en) 2020-10-27
JP7198867B2 (ja) 2023-01-04
JP2023021454A (ja) 2023-02-10
US20150361050A1 (en) 2015-12-17
CA2951883A1 (en) 2015-12-17
SG10201911925TA (en) 2020-01-30

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