SG10201911925TA - N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts - Google Patents
N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride saltsInfo
- Publication number
- SG10201911925TA SG10201911925TA SG10201911925TA SG10201911925TA SG10201911925TA SG 10201911925T A SG10201911925T A SG 10201911925TA SG 10201911925T A SG10201911925T A SG 10201911925TA SG 10201911925T A SG10201911925T A SG 10201911925TA SG 10201911925T A SG10201911925T A SG 10201911925TA
- Authority
- SG
- Singapore
- Prior art keywords
- morpholinophenylamino
- cyanomethyl
- pyrimidin
- benzamide hydrochloride
- hydrochloride salts
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462011315P | 2014-06-12 | 2014-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201911925TA true SG10201911925TA (en) | 2020-01-30 |
Family
ID=53674249
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201911925TA SG10201911925TA (en) | 2014-06-12 | 2015-06-11 | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts |
| SG11201610079VA SG11201610079VA (en) | 2014-06-12 | 2015-06-11 | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201610079VA SG11201610079VA (en) | 2014-06-12 | 2015-06-11 | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US9469613B2 (en) |
| EP (3) | EP3719005A1 (en) |
| JP (5) | JP6600649B2 (en) |
| KR (1) | KR101928225B1 (en) |
| CN (2) | CN106458929A (en) |
| AP (1) | AP2016009551A0 (en) |
| AR (1) | AR100818A1 (en) |
| AU (1) | AU2015274554B9 (en) |
| BR (1) | BR112016028749A2 (en) |
| CA (1) | CA2951883C (en) |
| CR (1) | CR20160575A (en) |
| CU (1) | CU20160183A7 (en) |
| CY (1) | CY1123604T1 (en) |
| DK (1) | DK3154950T3 (en) |
| EA (1) | EA032639B1 (en) |
| EC (1) | ECSP16093323A (en) |
| ES (1) | ES2822773T3 (en) |
| HR (1) | HRP20201492T1 (en) |
| HU (1) | HUE051360T2 (en) |
| IL (3) | IL249038B (en) |
| LT (1) | LT3154950T (en) |
| MA (1) | MA40067A (en) |
| MX (3) | MX2016016294A (en) |
| NZ (1) | NZ725966A (en) |
| PH (1) | PH12016502461A1 (en) |
| PL (1) | PL3154950T3 (en) |
| PT (1) | PT3154950T (en) |
| RS (1) | RS61065B1 (en) |
| SG (2) | SG10201911925TA (en) |
| SI (1) | SI3154950T1 (en) |
| TW (3) | TW202134236A (en) |
| UY (1) | UY36166A (en) |
| WO (1) | WO2015191846A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW202134236A (en) | 2014-06-12 | 2021-09-16 | 美商西爾拉癌症醫學公司 | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide |
| CN106316964B (en) * | 2015-06-26 | 2019-06-25 | 苏州泽璟生物制药股份有限公司 | The polymorph of phenyl amino pyrimidine compounds or its salt |
| CN106316963B (en) * | 2015-06-26 | 2021-06-08 | 苏州泽璟生物制药股份有限公司 | Polymorphs of a morpholino phenylaminopyrimidine compound or salt thereof |
| TWI808055B (en) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Combination therapies of hdac inhibitors and pd-1 inhibitors |
| TWI794171B (en) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Combination therapies of hdac inhibitors and pd-l1 inhibitors |
| US10245268B2 (en) | 2016-08-10 | 2019-04-02 | Sierra Oncology, Inc. | Treatment of ACVR1-mediated diseases |
| JP2021523882A (en) * | 2018-05-15 | 2021-09-09 | ジエンス ハンセン ファーマセウティカル グループ カンパニー リミテッド | A pharmaceutical composition containing a small molecule EGFR inhibitor and a method for producing the same. |
| US11963962B2 (en) | 2018-08-21 | 2024-04-23 | Glaxosmithkline Llc | Platelet count-agnostic methods of treating myelofibrosis |
| EP3923948A4 (en) * | 2019-02-12 | 2022-11-16 | Impact Biomedicines, Inc. | Crystalline forms of a jak2 inhibitor |
| WO2023010111A1 (en) | 2021-07-30 | 2023-02-02 | Sierra Oncology, Inc. | Biomarker and patient selection in treatment for myelofibrosis |
| CN117794546A (en) | 2021-08-10 | 2024-03-29 | 葛兰素史密斯克莱有限责任公司 | Molotinib combination therapy |
| WO2023023473A1 (en) | 2021-08-16 | 2023-02-23 | Sierra Oncology, Inc. | Methods of using momelotinib to treat chronic kidney disease |
| WO2023152773A1 (en) * | 2022-02-14 | 2023-08-17 | Dr. Reddy's Institute Of Life Sciences | Solid forms of momelotinib salts and improved processes for the preparation of momelotinib |
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| US5559714A (en) | 1990-10-22 | 1996-09-24 | Hallmark Cards, Incorporated | Method and apparatus for display sequencing personalized social occasion products |
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| TW202134236A (en) | 2014-06-12 | 2021-09-16 | 美商西爾拉癌症醫學公司 | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide |
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2015
- 2015-06-10 TW TW110118088A patent/TW202134236A/en unknown
- 2015-06-10 TW TW108146991A patent/TWI729644B/en active
- 2015-06-10 TW TW104118766A patent/TWI681954B/en active
- 2015-06-11 CA CA2951883A patent/CA2951883C/en active Active
- 2015-06-11 BR BR112016028749A patent/BR112016028749A2/en not_active Application Discontinuation
- 2015-06-11 EA EA201692356A patent/EA032639B1/en not_active IP Right Cessation
- 2015-06-11 EP EP20161613.3A patent/EP3719005A1/en active Pending
- 2015-06-11 EP EP21174463.6A patent/EP3907219A1/en active Pending
- 2015-06-11 KR KR1020177000573A patent/KR101928225B1/en active IP Right Grant
- 2015-06-11 PT PT157390428T patent/PT3154950T/en unknown
- 2015-06-11 LT LTEP15739042.8T patent/LT3154950T/en unknown
- 2015-06-11 CR CR20160575A patent/CR20160575A/en unknown
- 2015-06-11 US US14/736,690 patent/US9469613B2/en not_active Ceased
- 2015-06-11 SI SI201531370T patent/SI3154950T1/en unknown
- 2015-06-11 WO PCT/US2015/035316 patent/WO2015191846A1/en active Application Filing
- 2015-06-11 CN CN201580031169.6A patent/CN106458929A/en active Pending
- 2015-06-11 HU HUE15739042A patent/HUE051360T2/en unknown
- 2015-06-11 ES ES15739042T patent/ES2822773T3/en active Active
- 2015-06-11 MX MX2016016294A patent/MX2016016294A/en active IP Right Grant
- 2015-06-11 PL PL15739042T patent/PL3154950T3/en unknown
- 2015-06-11 EP EP15739042.8A patent/EP3154950B1/en active Active
- 2015-06-11 MA MA040067A patent/MA40067A/en unknown
- 2015-06-11 SG SG10201911925TA patent/SG10201911925TA/en unknown
- 2015-06-11 AR ARP150101869A patent/AR100818A1/en unknown
- 2015-06-11 SG SG11201610079VA patent/SG11201610079VA/en unknown
- 2015-06-11 AP AP2016009551A patent/AP2016009551A0/en unknown
- 2015-06-11 RS RS20201158A patent/RS61065B1/en unknown
- 2015-06-11 NZ NZ725966A patent/NZ725966A/en unknown
- 2015-06-11 CN CN201910920874.1A patent/CN110627728A/en active Pending
- 2015-06-11 JP JP2016572271A patent/JP6600649B2/en active Active
- 2015-06-11 AU AU2015274554A patent/AU2015274554B9/en active Active
- 2015-06-11 DK DK15739042.8T patent/DK3154950T3/en active
- 2015-06-12 UY UY0001036166A patent/UY36166A/en not_active Application Discontinuation
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2016
- 2016-08-08 US US15/231,411 patent/US9809559B2/en active Active
- 2016-11-17 IL IL249038A patent/IL249038B/en unknown
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- 2016-12-08 MX MX2019009564A patent/MX2019009564A/en unknown
- 2016-12-09 EC ECIEPI201693323A patent/ECSP16093323A/en unknown
- 2016-12-09 CU CUP2016000183A patent/CU20160183A7/en unknown
- 2016-12-12 PH PH12016502461A patent/PH12016502461A1/en unknown
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2018
- 2018-09-03 JP JP2018164680A patent/JP6883560B2/en active Active
- 2018-10-18 US US16/164,681 patent/USRE48285E1/en active Active
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2020
- 2020-01-06 JP JP2020000332A patent/JP6840909B2/en active Active
- 2020-08-26 IL IL276948A patent/IL276948B/en unknown
- 2020-09-04 US US17/013,342 patent/USRE49445E1/en active Active
- 2020-09-18 HR HRP20201492TT patent/HRP20201492T1/en unknown
- 2020-10-05 CY CY20201100931T patent/CY1123604T1/en unknown
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2021
- 2021-05-10 JP JP2021079700A patent/JP7198867B2/en active Active
- 2021-09-15 IL IL286442A patent/IL286442A/en unknown
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2022
- 2022-12-19 JP JP2022202374A patent/JP2023021454A/en active Pending
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