RS61065B1 - Hidrohloridne soli n-(cijanometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida - Google Patents
Hidrohloridne soli n-(cijanometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamidaInfo
- Publication number
- RS61065B1 RS61065B1 RS20201158A RSP20201158A RS61065B1 RS 61065 B1 RS61065 B1 RS 61065B1 RS 20201158 A RS20201158 A RS 20201158A RS P20201158 A RSP20201158 A RS P20201158A RS 61065 B1 RS61065 B1 RS 61065B1
- Authority
- RS
- Serbia
- Prior art keywords
- morpholinophenylamino
- cyanomethyl
- pyrimidin
- benzamide hydrochloride
- hydrochloride salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462011315P | 2014-06-12 | 2014-06-12 | |
| PCT/US2015/035316 WO2015191846A1 (en) | 2014-06-12 | 2015-06-11 | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts |
| EP15739042.8A EP3154950B1 (en) | 2014-06-12 | 2015-06-11 | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS61065B1 true RS61065B1 (sr) | 2020-12-31 |
Family
ID=53674249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20201158A RS61065B1 (sr) | 2014-06-12 | 2015-06-11 | Hidrohloridne soli n-(cijanometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US9469613B2 (sr) |
| EP (3) | EP3719005A1 (sr) |
| JP (5) | JP6600649B2 (sr) |
| KR (1) | KR101928225B1 (sr) |
| CN (2) | CN110627728A (sr) |
| AP (1) | AP2016009551A0 (sr) |
| AR (1) | AR100818A1 (sr) |
| AU (1) | AU2015274554B9 (sr) |
| BR (1) | BR112016028749A2 (sr) |
| CA (1) | CA2951883C (sr) |
| CR (1) | CR20160575A (sr) |
| CU (1) | CU20160183A7 (sr) |
| CY (1) | CY1123604T1 (sr) |
| DK (1) | DK3154950T3 (sr) |
| EA (1) | EA032639B1 (sr) |
| EC (1) | ECSP16093323A (sr) |
| ES (1) | ES2822773T3 (sr) |
| HR (1) | HRP20201492T1 (sr) |
| HU (1) | HUE051360T2 (sr) |
| IL (3) | IL249038B (sr) |
| LT (1) | LT3154950T (sr) |
| MA (1) | MA40067A (sr) |
| MX (3) | MX2016016294A (sr) |
| NZ (1) | NZ725966A (sr) |
| PH (1) | PH12016502461A1 (sr) |
| PL (1) | PL3154950T3 (sr) |
| PT (1) | PT3154950T (sr) |
| RS (1) | RS61065B1 (sr) |
| SG (2) | SG10201911925TA (sr) |
| SI (1) | SI3154950T1 (sr) |
| TW (3) | TWI681954B (sr) |
| UY (1) | UY36166A (sr) |
| WO (1) | WO2015191846A1 (sr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI681954B (zh) | 2014-06-12 | 2020-01-11 | 美商西爾拉癌症醫學公司 | Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺 |
| CN106316964B (zh) * | 2015-06-26 | 2019-06-25 | 苏州泽璟生物制药股份有限公司 | 苯基氨基嘧啶化合物或其盐的多晶型物 |
| CN106316963B (zh) * | 2015-06-26 | 2021-06-08 | 苏州泽璟生物制药股份有限公司 | 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US10245268B2 (en) | 2016-08-10 | 2019-04-02 | Sierra Oncology, Inc. | Treatment of ACVR1-mediated diseases |
| AU2019269815A1 (en) * | 2018-05-15 | 2020-10-22 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Pharmaceutical composition comprising small molecule EGFR inhibitor and preparation method therefor |
| KR20210047308A (ko) * | 2018-08-21 | 2021-04-29 | 시에라 온코로지, 인코퍼레이티드 | 골수섬유증을 치료하는 혈소판 수-불특정 방법 |
| US20230250068A1 (en) * | 2019-02-12 | 2023-08-10 | Inpact Biomedicines, Inc. | Crystalline forms of a jak2 inhibitor |
| EP4376849A1 (en) | 2021-07-30 | 2024-06-05 | GlaxoSmithKline LLC | Biomarker and patient selection in treatment for myelofibrosis |
| WO2023019095A2 (en) | 2021-08-10 | 2023-02-16 | Sierra Oncology, Inc. | Momelotinib combination therapy |
| WO2023023473A1 (en) | 2021-08-16 | 2023-02-23 | Sierra Oncology, Inc. | Methods of using momelotinib to treat chronic kidney disease |
| WO2023152773A1 (en) * | 2022-02-14 | 2023-08-17 | Dr. Reddy's Institute Of Life Sciences | Solid forms of momelotinib salts and improved processes for the preparation of momelotinib |
Family Cites Families (51)
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| US3481932A (en) | 1967-09-01 | 1969-12-02 | Searle & Co | 2-anilino-5-methyl-6-phenylpyrimidines and congeners |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5120764A (en) | 1988-11-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4997854A (en) | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
| US5559714A (en) | 1990-10-22 | 1996-09-24 | Hallmark Cards, Incorporated | Method and apparatus for display sequencing personalized social occasion products |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| CA2436487A1 (en) | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd. | Methods of inhibiting kinases |
| DE60223790D1 (de) | 2001-03-29 | 2008-01-10 | Vertex Pharma | Hemmer von c-jun-terminal kinase (jnk) und andere protein kinase |
| FR2828206B1 (fr) | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| US6433018B1 (en) | 2001-08-31 | 2002-08-13 | The Research Foundation Of State University Of New York | Method for reducing hypertrophy and ischemia |
| WO2003022244A1 (en) | 2001-09-12 | 2003-03-20 | Virexx Research, Inc. | Vascular occlusion solid-phase agent with immobilised platelet binding agent |
| US7122550B2 (en) | 2002-05-23 | 2006-10-17 | Cytopia Pty Ltd | Protein kinase inhibitors |
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| AU2003286895A1 (en) | 2002-11-05 | 2004-06-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of jak and other protein kinases |
| GB0317841D0 (en) | 2003-07-30 | 2003-09-03 | Cyclacel Ltd | Compound |
| CA2533474A1 (en) | 2003-07-30 | 2005-02-10 | Shudong Wang | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
| LT2612862T (lt) | 2004-05-13 | 2017-01-25 | Icos Corporation | Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės delta inhibitoriai |
| BRPI0516597A (pt) | 2004-10-13 | 2008-09-16 | Wyeth Corp | composto da fórmula |
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| EP3023422A1 (en) | 2007-03-12 | 2016-05-25 | YM BioSciences Australia Pty Ltd | Phenyl amino pyrimidine compounds and uses thereof |
| AU2016200866B2 (en) | 2007-03-12 | 2017-06-22 | Glaxosmithkline Llc | Phenyl amino pyrimidine compounds and uses thereof |
| AU2013201306B2 (en) | 2007-03-12 | 2015-11-12 | Glaxosmithkline Llc | Phenyl Amino Pyrimidine Compounds and Uses Thereof |
| EP2200436B1 (en) | 2007-09-04 | 2015-01-21 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
| WO2009029998A1 (en) | 2007-09-06 | 2009-03-12 | Cytopia Research Pty Ltd | Retrometabolic compounds |
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| WO2010017122A2 (en) | 2008-08-05 | 2010-02-11 | Targegen Inc. | Methods of treating thalassemia |
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| WO2012071612A1 (en) | 2010-12-03 | 2012-06-07 | Ym Biosciences Australia Pty Ltd | Treatment of jak2-mediated conditions |
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| US8809359B2 (en) | 2012-06-29 | 2014-08-19 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
| WO2014051056A1 (ja) * | 2012-09-28 | 2014-04-03 | 東レ株式会社 | グリシン誘導体の結晶及びその医薬用途 |
| AU2014205472B2 (en) | 2013-01-09 | 2018-05-10 | Concert Pharmaceuticals Inc. | Deuterated momelotinib |
| CN103965114B (zh) | 2013-01-28 | 2016-01-06 | 苏州泽璟生物制药有限公司 | 氘代的苯基氨基嘧啶化合物以及包含该化合物的药物组合物 |
| TWI681954B (zh) * | 2014-06-12 | 2020-01-11 | 美商西爾拉癌症醫學公司 | Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺 |
-
2015
- 2015-06-10 TW TW104118766A patent/TWI681954B/zh active
- 2015-06-10 TW TW110118088A patent/TW202134236A/zh unknown
- 2015-06-10 TW TW108146991A patent/TWI729644B/zh active
- 2015-06-11 LT LTEP15739042.8T patent/LT3154950T/lt unknown
- 2015-06-11 KR KR1020177000573A patent/KR101928225B1/ko active IP Right Grant
- 2015-06-11 EA EA201692356A patent/EA032639B1/ru not_active IP Right Cessation
- 2015-06-11 CR CR20160575A patent/CR20160575A/es unknown
- 2015-06-11 SG SG10201911925TA patent/SG10201911925TA/en unknown
- 2015-06-11 HU HUE15739042A patent/HUE051360T2/hu unknown
- 2015-06-11 AU AU2015274554A patent/AU2015274554B9/en active Active
- 2015-06-11 EP EP20161613.3A patent/EP3719005A1/en active Pending
- 2015-06-11 US US14/736,690 patent/US9469613B2/en not_active Ceased
- 2015-06-11 BR BR112016028749A patent/BR112016028749A2/pt not_active Application Discontinuation
- 2015-06-11 SG SG11201610079VA patent/SG11201610079VA/en unknown
- 2015-06-11 EP EP15739042.8A patent/EP3154950B1/en active Active
- 2015-06-11 PT PT157390428T patent/PT3154950T/pt unknown
- 2015-06-11 PL PL15739042T patent/PL3154950T3/pl unknown
- 2015-06-11 WO PCT/US2015/035316 patent/WO2015191846A1/en active Application Filing
- 2015-06-11 RS RS20201158A patent/RS61065B1/sr unknown
- 2015-06-11 DK DK15739042.8T patent/DK3154950T3/da active
- 2015-06-11 CN CN201910920874.1A patent/CN110627728A/zh active Pending
- 2015-06-11 CN CN201580031169.6A patent/CN106458929A/zh active Pending
- 2015-06-11 NZ NZ725966A patent/NZ725966A/en unknown
- 2015-06-11 MX MX2016016294A patent/MX2016016294A/es active IP Right Grant
- 2015-06-11 SI SI201531370T patent/SI3154950T1/sl unknown
- 2015-06-11 MA MA040067A patent/MA40067A/fr unknown
- 2015-06-11 ES ES15739042T patent/ES2822773T3/es active Active
- 2015-06-11 CA CA2951883A patent/CA2951883C/en active Active
- 2015-06-11 AR ARP150101869A patent/AR100818A1/es unknown
- 2015-06-11 JP JP2016572271A patent/JP6600649B2/ja active Active
- 2015-06-11 AP AP2016009551A patent/AP2016009551A0/en unknown
- 2015-06-11 EP EP21174463.6A patent/EP3907219A1/en active Pending
- 2015-06-12 UY UY0001036166A patent/UY36166A/es not_active Application Discontinuation
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2016
- 2016-08-08 US US15/231,411 patent/US9809559B2/en active Active
- 2016-11-17 IL IL249038A patent/IL249038B/en unknown
- 2016-12-08 MX MX2022015558A patent/MX2022015558A/es unknown
- 2016-12-08 MX MX2019009564A patent/MX2019009564A/es unknown
- 2016-12-09 EC ECIEPI201693323A patent/ECSP16093323A/es unknown
- 2016-12-09 CU CUP2016000183A patent/CU20160183A7/es unknown
- 2016-12-12 PH PH12016502461A patent/PH12016502461A1/en unknown
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2018
- 2018-09-03 JP JP2018164680A patent/JP6883560B2/ja active Active
- 2018-10-18 US US16/164,681 patent/USRE48285E1/en active Active
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2020
- 2020-01-06 JP JP2020000332A patent/JP6840909B2/ja active Active
- 2020-08-26 IL IL276948A patent/IL276948B/en unknown
- 2020-09-04 US US17/013,342 patent/USRE49445E1/en active Active
- 2020-09-18 HR HRP20201492TT patent/HRP20201492T1/hr unknown
- 2020-10-05 CY CY20201100931T patent/CY1123604T1/el unknown
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2021
- 2021-05-10 JP JP2021079700A patent/JP7198867B2/ja active Active
- 2021-09-15 IL IL286442A patent/IL286442A/en unknown
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2022
- 2022-12-19 JP JP2022202374A patent/JP2023021454A/ja active Pending
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