EA201692356A1 - Гидрохлоридные соли n-(цианометил)-4-(2-(4-морфолинофениламино)пиримидин-4-ил)бензамида - Google Patents

Гидрохлоридные соли n-(цианометил)-4-(2-(4-морфолинофениламино)пиримидин-4-ил)бензамида

Info

Publication number
EA201692356A1
EA201692356A1 EA201692356A EA201692356A EA201692356A1 EA 201692356 A1 EA201692356 A1 EA 201692356A1 EA 201692356 A EA201692356 A EA 201692356A EA 201692356 A EA201692356 A EA 201692356A EA 201692356 A1 EA201692356 A1 EA 201692356A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyanomethyl
pyrimidin
morfolinophenylamino
benzmide
hydrochloride salts
Prior art date
Application number
EA201692356A
Other languages
English (en)
Other versions
EA032639B1 (ru
Inventor
Брендон Х. Браун
Эрнест А. Карра
Джеффри Н. Хименвэй
Генри Моррисон
Трой Рейнолдс
Бин Ши
Димитриос Стефанидис
Фан Ван
Мэттью Роберт Уорр
Джеймс Эндрю Уитни
Янь Синь
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53674249&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201692356(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201692356A1 publication Critical patent/EA201692356A1/ru
Publication of EA032639B1 publication Critical patent/EA032639B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к стабильным новым солевым формам N-(цианометил)-4-(2-(4-морфолинофениламино)пиримидин-4-ил)бензамида, которые подходят для получения фармацевтических составов, и к их терапевтическому применению.
EA201692356A 2014-06-12 2015-06-11 Гидрохлоридные соли n-(цианометил)-4-(2-(4-морфолинофениламино)пиримидин-4-ил)бензамида EA032639B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462011315P 2014-06-12 2014-06-12
PCT/US2015/035316 WO2015191846A1 (en) 2014-06-12 2015-06-11 N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts

Publications (2)

Publication Number Publication Date
EA201692356A1 true EA201692356A1 (ru) 2017-07-31
EA032639B1 EA032639B1 (ru) 2019-06-28

Family

ID=53674249

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692356A EA032639B1 (ru) 2014-06-12 2015-06-11 Гидрохлоридные соли n-(цианометил)-4-(2-(4-морфолинофениламино)пиримидин-4-ил)бензамида

Country Status (33)

Country Link
US (4) US9469613B2 (ru)
EP (3) EP3719005A1 (ru)
JP (5) JP6600649B2 (ru)
KR (1) KR101928225B1 (ru)
CN (2) CN110627728A (ru)
AP (1) AP2016009551A0 (ru)
AR (1) AR100818A1 (ru)
AU (1) AU2015274554B9 (ru)
BR (1) BR112016028749A2 (ru)
CA (1) CA2951883C (ru)
CR (1) CR20160575A (ru)
CU (1) CU20160183A7 (ru)
CY (1) CY1123604T1 (ru)
DK (1) DK3154950T3 (ru)
EA (1) EA032639B1 (ru)
EC (1) ECSP16093323A (ru)
ES (1) ES2822773T3 (ru)
HR (1) HRP20201492T1 (ru)
HU (1) HUE051360T2 (ru)
IL (3) IL249038B (ru)
LT (1) LT3154950T (ru)
MA (1) MA40067A (ru)
MX (3) MX2016016294A (ru)
NZ (1) NZ725966A (ru)
PH (1) PH12016502461A1 (ru)
PL (1) PL3154950T3 (ru)
PT (1) PT3154950T (ru)
RS (1) RS61065B1 (ru)
SG (2) SG10201911925TA (ru)
SI (1) SI3154950T1 (ru)
TW (3) TWI681954B (ru)
UY (1) UY36166A (ru)
WO (1) WO2015191846A1 (ru)

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US9809559B2 (en) 2017-11-07
AU2015274554B2 (en) 2018-02-15
EP3719005A1 (en) 2020-10-07
LT3154950T (lt) 2020-11-25
NZ725966A (en) 2018-04-27
CA2951883C (en) 2020-05-05
IL286442A (en) 2021-10-31
JP2018184486A (ja) 2018-11-22
TWI681954B (zh) 2020-01-11
SG11201610079VA (en) 2016-12-29
BR112016028749A2 (pt) 2017-08-22
USRE49445E1 (en) 2023-03-07
JP6600649B2 (ja) 2019-10-30
HUE051360T2 (hu) 2021-03-01
EP3907219A1 (en) 2021-11-10
MX2019009564A (es) 2019-10-02
PT3154950T (pt) 2020-10-09
WO2015191846A1 (en) 2015-12-17
IL276948A (en) 2020-10-29
KR101928225B1 (ko) 2018-12-11
JP2021107465A (ja) 2021-07-29
ES2822773T3 (es) 2021-05-04
KR20170015496A (ko) 2017-02-08
JP2017517535A (ja) 2017-06-29
IL249038A0 (en) 2017-01-31
PH12016502461A1 (en) 2017-03-06
TW201617323A (zh) 2016-05-16
US20160347719A1 (en) 2016-12-01
MX2016016294A (es) 2017-09-01
ECSP16093323A (es) 2017-01-31
HRP20201492T1 (hr) 2021-01-08
EP3154950A1 (en) 2017-04-19
CN106458929A (zh) 2017-02-22
TW202134236A (zh) 2021-09-16
AR100818A1 (es) 2016-11-02
AP2016009551A0 (en) 2016-11-30
SI3154950T1 (sl) 2021-01-29
DK3154950T3 (da) 2020-09-14
JP2020059759A (ja) 2020-04-16
CN110627728A (zh) 2019-12-31
EP3154950B1 (en) 2020-08-05
UY36166A (es) 2016-01-29
JP6840909B2 (ja) 2021-03-10
IL276948B (en) 2021-09-30
AU2015274554B9 (en) 2018-04-19
US9469613B2 (en) 2016-10-18
MA40067A (fr) 2015-12-17
RS61065B1 (sr) 2020-12-31
CU20160183A7 (es) 2017-05-10
JP6883560B2 (ja) 2021-06-09
CY1123604T1 (el) 2022-03-24
AU2015274554A1 (en) 2016-11-24
TWI729644B (zh) 2021-06-01
CR20160575A (es) 2017-01-20
EA032639B1 (ru) 2019-06-28
PL3154950T3 (pl) 2021-01-25
TW202012378A (zh) 2020-04-01
MX2022015558A (es) 2023-01-30
IL249038B (en) 2020-09-30
USRE48285E1 (en) 2020-10-27
JP7198867B2 (ja) 2023-01-04
JP2023021454A (ja) 2023-02-10
US20150361050A1 (en) 2015-12-17
CA2951883A1 (en) 2015-12-17
SG10201911925TA (en) 2020-01-30

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