AR100818A1 - N-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida - Google Patents
N-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamidaInfo
- Publication number
- AR100818A1 AR100818A1 ARP150101869A ARP150101869A AR100818A1 AR 100818 A1 AR100818 A1 AR 100818A1 AR P150101869 A ARP150101869 A AR P150101869A AR P150101869 A ARP150101869 A AR P150101869A AR 100818 A1 AR100818 A1 AR 100818A1
- Authority
- AR
- Argentina
- Prior art keywords
- morpholinophenylamino
- cyanomethyl
- pyrimidin
- morfolinofenilamino
- cyanometil
- Prior art date
Links
- ZVHNDZWQTBEVRY-UHFFFAOYSA-N momelotinib Chemical compound C1=CC(C(NCC#N)=O)=CC=C1C1=CC=NC(NC=2C=CC(=CC=2)N2CCOCC2)=N1 ZVHNDZWQTBEVRY-UHFFFAOYSA-N 0.000 abstract 3
- 102000015617 Janus Kinases Human genes 0.000 abstract 2
- 108010024121 Janus Kinases Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462011315P | 2014-06-12 | 2014-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100818A1 true AR100818A1 (es) | 2016-11-02 |
Family
ID=53674249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101869A AR100818A1 (es) | 2014-06-12 | 2015-06-11 | N-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida |
Country Status (37)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI681954B (zh) * | 2014-06-12 | 2020-01-11 | 美商西爾拉癌症醫學公司 | Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺 |
| CN106316963B (zh) * | 2015-06-26 | 2021-06-08 | 苏州泽璟生物制药股份有限公司 | 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物 |
| CN106316964B (zh) * | 2015-06-26 | 2019-06-25 | 苏州泽璟生物制药股份有限公司 | 苯基氨基嘧啶化合物或其盐的多晶型物 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US10245268B2 (en) | 2016-08-10 | 2019-04-02 | Sierra Oncology, Inc. | Treatment of ACVR1-mediated diseases |
| CA3097594A1 (en) * | 2018-05-15 | 2019-11-21 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Pharmaceutical composition comprising small molecule egfr inhibitor and preparation method therefor |
| MX2021001985A (es) * | 2018-08-21 | 2021-04-28 | Sierra Oncology Inc | Metodos agnosticos de conteo de plaquetas para tratar la mielofibrosis. |
| US12559463B2 (en) | 2019-02-12 | 2026-02-24 | Impact Biomedicines Inc. | Crystalline forms of a JAK2 inhibitor |
| CA3156007A1 (en) | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS |
| AU2021273014A1 (en) | 2020-05-13 | 2022-11-17 | AbbVie Deutschland GmbH & Co. KG | Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease |
| ES3075793T3 (en) | 2020-05-13 | 2026-08-07 | Disc Medicine Inc | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| CN117794545A (zh) | 2021-07-30 | 2024-03-29 | 葛兰素史密斯克莱有限责任公司 | 骨髓纤维化的治疗中的生物标志物和患者选择 |
| WO2023019095A2 (en) | 2021-08-10 | 2023-02-16 | Sierra Oncology, Inc. | Momelotinib combination therapy |
| WO2023023473A1 (en) | 2021-08-16 | 2023-02-23 | Sierra Oncology, Inc. | Methods of using momelotinib to treat chronic kidney disease |
| CN115957221B (zh) * | 2021-10-09 | 2026-01-06 | 广东东阳光药业股份有限公司 | 抗纤维化组合物 |
| WO2023152773A1 (en) * | 2022-02-14 | 2023-08-17 | Dr. Reddy's Institute Of Life Sciences | Solid forms of momelotinib salts and improved processes for the preparation of momelotinib |
| CN119704552B (zh) * | 2025-02-08 | 2025-06-13 | 泰州南洋塑料制品有限公司 | 一种电池槽注塑模具及边缘毛刺废料处理回收装置 |
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| TWI681954B (zh) | 2014-06-12 | 2020-01-11 | 美商西爾拉癌症醫學公司 | Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺 |
| CN106316964B (zh) * | 2015-06-26 | 2019-06-25 | 苏州泽璟生物制药股份有限公司 | 苯基氨基嘧啶化合物或其盐的多晶型物 |
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2015
- 2015-06-10 TW TW104118766A patent/TWI681954B/zh active
- 2015-06-10 TW TW110118088A patent/TW202134236A/zh unknown
- 2015-06-10 TW TW108146991A patent/TWI729644B/zh active
- 2015-06-11 JP JP2016572271A patent/JP6600649B2/ja active Active
- 2015-06-11 MX MX2016016294A patent/MX374541B/es active IP Right Grant
- 2015-06-11 EA EA201692356A patent/EA032639B1/ru not_active IP Right Cessation
- 2015-06-11 CN CN201580031169.6A patent/CN106458929A/zh active Pending
- 2015-06-11 CA CA2951883A patent/CA2951883C/en active Active
- 2015-06-11 AU AU2015274554A patent/AU2015274554B9/en active Active
- 2015-06-11 AR ARP150101869A patent/AR100818A1/es unknown
- 2015-06-11 SG SG11201610079VA patent/SG11201610079VA/en unknown
- 2015-06-11 HR HRP20201492TT patent/HRP20201492T1/hr unknown
- 2015-06-11 CN CN201910920874.1A patent/CN110627728A/zh active Pending
- 2015-06-11 EP EP15739042.8A patent/EP3154950B1/en active Active
- 2015-06-11 BR BR112016028749A patent/BR112016028749A2/pt not_active Application Discontinuation
- 2015-06-11 CR CR20160575A patent/CR20160575A/es unknown
- 2015-06-11 PT PT157390428T patent/PT3154950T/pt unknown
- 2015-06-11 MA MA040067A patent/MA40067A/fr unknown
- 2015-06-11 PL PL15739042T patent/PL3154950T3/pl unknown
- 2015-06-11 WO PCT/US2015/035316 patent/WO2015191846A1/en not_active Ceased
- 2015-06-11 ES ES15739042T patent/ES2822773T3/es active Active
- 2015-06-11 SI SI201531370T patent/SI3154950T1/sl unknown
- 2015-06-11 US US14/736,690 patent/US9469613B2/en not_active Ceased
- 2015-06-11 HU HUE15739042A patent/HUE051360T2/hu unknown
- 2015-06-11 EP EP20161613.3A patent/EP3719005A1/en not_active Ceased
- 2015-06-11 DK DK15739042.8T patent/DK3154950T3/da active
- 2015-06-11 KR KR1020177000573A patent/KR101928225B1/ko active Active
- 2015-06-11 SG SG10201911925TA patent/SG10201911925TA/en unknown
- 2015-06-11 LT LTEP15739042.8T patent/LT3154950T/lt unknown
- 2015-06-11 AP AP2016009551A patent/AP2016009551A0/en unknown
- 2015-06-11 NZ NZ725966A patent/NZ725966A/en unknown
- 2015-06-11 EP EP21174463.6A patent/EP3907219A1/en active Pending
- 2015-06-11 RS RS20201158A patent/RS61065B1/sr unknown
- 2015-06-12 UY UY0001036166A patent/UY36166A/es not_active Application Discontinuation
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2016
- 2016-08-08 US US15/231,411 patent/US9809559B2/en active Active
- 2016-11-17 IL IL249038A patent/IL249038B/en unknown
- 2016-12-08 MX MX2022015558A patent/MX2022015558A/es unknown
- 2016-12-08 MX MX2019009564A patent/MX2019009564A/es unknown
- 2016-12-09 EC ECIEPI201693323A patent/ECSP16093323A/es unknown
- 2016-12-09 CU CUP2016000183A patent/CU20160183A7/es unknown
- 2016-12-12 PH PH12016502461A patent/PH12016502461A1/en unknown
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2018
- 2018-09-03 JP JP2018164680A patent/JP6883560B2/ja active Active
- 2018-10-18 US US16/164,681 patent/USRE48285E1/en active Active
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2020
- 2020-01-06 JP JP2020000332A patent/JP6840909B2/ja active Active
- 2020-08-26 IL IL276948A patent/IL276948B/en unknown
- 2020-09-04 US US17/013,342 patent/USRE49445E1/en active Active
- 2020-10-05 CY CY20201100931T patent/CY1123604T1/el unknown
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2021
- 2021-05-10 JP JP2021079700A patent/JP7198867B2/ja active Active
- 2021-09-15 IL IL286442A patent/IL286442A/en unknown
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2022
- 2022-12-19 JP JP2022202374A patent/JP7550205B2/ja active Active
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2023
- 2023-01-25 US US18/159,328 patent/USRE50497E1/en active Active
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2024
- 2024-07-11 LT LTPA2024523C patent/LTPA2024523I1/lt unknown
- 2024-07-11 FR FR24C1030C patent/FR24C1030I2/fr active Active
- 2024-07-12 NL NL301282C patent/NL301282I2/nl unknown
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- 2024-07-15 HU HUS2400025C patent/HUS2400025I1/hu unknown
- 2024-07-17 CY CY2024024C patent/CY2024024I2/el unknown
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