CY1123604T1 - Υδροχλωρικα αλατα ν-(κυανομεθυλ)-4-(2-(4-μορφολινοφαινυλαμινο)πυριμιδιν-4-υλ)βενζαμιδιου - Google Patents
Υδροχλωρικα αλατα ν-(κυανομεθυλ)-4-(2-(4-μορφολινοφαινυλαμινο)πυριμιδιν-4-υλ)βενζαμιδιουInfo
- Publication number
- CY1123604T1 CY1123604T1 CY20201100931T CY201100931T CY1123604T1 CY 1123604 T1 CY1123604 T1 CY 1123604T1 CY 20201100931 T CY20201100931 T CY 20201100931T CY 201100931 T CY201100931 T CY 201100931T CY 1123604 T1 CY1123604 T1 CY 1123604T1
- Authority
- CY
- Cyprus
- Prior art keywords
- morpholinophenylamino
- cyanomethyl
- pyrimidin
- benzamido
- hydrochloride salts
- Prior art date
Links
- -1 N-(CYANOMETHYL)-4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDO HYDROCHLORIDE SALTS Chemical class 0.000 title 1
- ZVHNDZWQTBEVRY-UHFFFAOYSA-N momelotinib Chemical compound C1=CC(C(NCC#N)=O)=CC=C1C1=CC=NC(NC=2C=CC(=CC=2)N2CCOCC2)=N1 ZVHNDZWQTBEVRY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462011315P | 2014-06-12 | 2014-06-12 | |
| PCT/US2015/035316 WO2015191846A1 (en) | 2014-06-12 | 2015-06-11 | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123604T1 true CY1123604T1 (el) | 2022-03-24 |
Family
ID=53674249
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100931T CY1123604T1 (el) | 2014-06-12 | 2020-10-05 | Υδροχλωρικα αλατα ν-(κυανομεθυλ)-4-(2-(4-μορφολινοφαινυλαμινο)πυριμιδιν-4-υλ)βενζαμιδιου |
| CY2024024C CY2024024I2 (el) | 2014-06-12 | 2024-07-17 | Υδροχλωρικα αλατα ν-(κυανομεθυλ)-4-(2-(4- μορφολινοφαινυλαμινο)πυριμιδιν-4-υλ)βενζαμιδιου |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY2024024C CY2024024I2 (el) | 2014-06-12 | 2024-07-17 | Υδροχλωρικα αλατα ν-(κυανομεθυλ)-4-(2-(4- μορφολινοφαινυλαμινο)πυριμιδιν-4-υλ)βενζαμιδιου |
Country Status (37)
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| TWI681954B (zh) * | 2014-06-12 | 2020-01-11 | 美商西爾拉癌症醫學公司 | Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺 |
| CN106316963B (zh) * | 2015-06-26 | 2021-06-08 | 苏州泽璟生物制药股份有限公司 | 吗啡啉苯基氨基嘧啶化合物或其盐的多晶型物 |
| CN106316964B (zh) * | 2015-06-26 | 2019-06-25 | 苏州泽璟生物制药股份有限公司 | 苯基氨基嘧啶化合物或其盐的多晶型物 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US10245268B2 (en) | 2016-08-10 | 2019-04-02 | Sierra Oncology, Inc. | Treatment of ACVR1-mediated diseases |
| CA3097594A1 (en) * | 2018-05-15 | 2019-11-21 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Pharmaceutical composition comprising small molecule egfr inhibitor and preparation method therefor |
| MX2021001985A (es) * | 2018-08-21 | 2021-04-28 | Sierra Oncology Inc | Metodos agnosticos de conteo de plaquetas para tratar la mielofibrosis. |
| US12559463B2 (en) | 2019-02-12 | 2026-02-24 | Impact Biomedicines Inc. | Crystalline forms of a JAK2 inhibitor |
| CA3156007A1 (en) | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS |
| AU2021273014A1 (en) | 2020-05-13 | 2022-11-17 | AbbVie Deutschland GmbH & Co. KG | Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease |
| ES3075793T3 (en) | 2020-05-13 | 2026-08-07 | Disc Medicine Inc | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| CN117794545A (zh) | 2021-07-30 | 2024-03-29 | 葛兰素史密斯克莱有限责任公司 | 骨髓纤维化的治疗中的生物标志物和患者选择 |
| WO2023019095A2 (en) | 2021-08-10 | 2023-02-16 | Sierra Oncology, Inc. | Momelotinib combination therapy |
| WO2023023473A1 (en) | 2021-08-16 | 2023-02-23 | Sierra Oncology, Inc. | Methods of using momelotinib to treat chronic kidney disease |
| CN115957221B (zh) * | 2021-10-09 | 2026-01-06 | 广东东阳光药业股份有限公司 | 抗纤维化组合物 |
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| CN119704552B (zh) * | 2025-02-08 | 2025-06-13 | 泰州南洋塑料制品有限公司 | 一种电池槽注塑模具及边缘毛刺废料处理回收装置 |
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2015
- 2015-06-10 TW TW104118766A patent/TWI681954B/zh active
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- 2015-06-11 JP JP2016572271A patent/JP6600649B2/ja active Active
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- 2015-06-11 EA EA201692356A patent/EA032639B1/ru not_active IP Right Cessation
- 2015-06-11 CN CN201580031169.6A patent/CN106458929A/zh active Pending
- 2015-06-11 CA CA2951883A patent/CA2951883C/en active Active
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- 2015-06-11 EP EP15739042.8A patent/EP3154950B1/en active Active
- 2015-06-11 BR BR112016028749A patent/BR112016028749A2/pt not_active Application Discontinuation
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- 2015-06-11 MA MA040067A patent/MA40067A/fr unknown
- 2015-06-11 PL PL15739042T patent/PL3154950T3/pl unknown
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- 2015-06-11 ES ES15739042T patent/ES2822773T3/es active Active
- 2015-06-11 SI SI201531370T patent/SI3154950T1/sl unknown
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2016
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2018
- 2018-09-03 JP JP2018164680A patent/JP6883560B2/ja active Active
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2020
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2021
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2022
- 2022-12-19 JP JP2022202374A patent/JP7550205B2/ja active Active
-
2023
- 2023-01-25 US US18/159,328 patent/USRE50497E1/en active Active
-
2024
- 2024-07-11 LT LTPA2024523C patent/LTPA2024523I1/lt unknown
- 2024-07-11 FR FR24C1030C patent/FR24C1030I2/fr active Active
- 2024-07-12 NL NL301282C patent/NL301282I2/nl unknown
- 2024-07-12 FI FIC20240025C patent/FIC20240025I1/fi unknown
- 2024-07-15 LU LU00353C patent/LUC00353I2/fr unknown
- 2024-07-15 HU HUS2400025C patent/HUS2400025I1/hu unknown
- 2024-07-17 CY CY2024024C patent/CY2024024I2/el unknown
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