CN106266889A - A kind of department of obstetrics and gynecology medicine treating endocrine disturbance and preparation method thereof - Google Patents

A kind of department of obstetrics and gynecology medicine treating endocrine disturbance and preparation method thereof Download PDF

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CN106266889A
CN106266889A CN201610763743.3A CN201610763743A CN106266889A CN 106266889 A CN106266889 A CN 106266889A CN 201610763743 A CN201610763743 A CN 201610763743A CN 106266889 A CN106266889 A CN 106266889A
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herba
rhizoma
testis
saururi
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孙婧
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9062Alpinia, e.g. red ginger or galangal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a kind of department of obstetrics and gynecology medicine treating endocrine disturbance and preparation method thereof, described medicine is made up according to the raw material of weight portion of following: Semen Cuscutae 10 20 parts, downy rosemyrtle root 15 25 parts, Radix Angelicae Sinensis 50 60 parts, Radix Pseudostellariae 50 60 parts, Testis et penis callorhini 46 parts, Testis Et penis Equi 26 parts, Yunnan Caulis Spatholobi 2 10 parts, Rhizoma Corydalis 15 25 parts, Herba Ecliptae 20 30 parts, Semen Astragali Complanati 10 20 parts, Herba Salviae Chinensis 24 parts, Rhizoma Alpiniae Officinarum 48 parts, Rhizoma Saururi (Herba Saururi) 10 20 parts, Semen Ziziphi Spinosae 10 20 parts, Herba Dianthi 15 25 parts, the Rhizoma Atractylodis Macrocephalae 10 15 parts;Each raw material is prepared as thick paste through techniques such as decoction, ethanol extraction, rice wine immersions, and thick paste prepares the department of obstetrics and gynecology medicine for the treatment of endocrine disturbance through conventional method, and this medicine is tablet, capsule, granule or electuary;The present invention can effectively treat that the dysmenorrhea because endocrine disturbance causes, menstrual period are irregular, sterility and infertility symptom;Instant effect, determined curative effect, have no side effect, treating both the principal and secondary aspects of a disease, drug cost low, be worth being widely popularized in clinic.

Description

A kind of department of obstetrics and gynecology medicine treating endocrine disturbance and preparation method thereof
Technical field
The present invention relates to technical field of Chinese medicines, a kind of department of obstetrics and gynecology medicine treating endocrine disturbance and preparation side thereof Method.
Background technology
Endocrine disturbance is the major reason causing female infertility, the foundation of normal ovulatory cycle need hypothalamus-hang down Body-hypothalamic pituitary ovarium axis function is normal, and one position dysfunction of any of which all may cause not ovulating, and then causes menolipsis, the moon Through dilute, anovulatory dysfunctional uterine hemorrhage etc., cause the outbreak of infertility, the infertility i.e. endocrine caused due to this endocrine reason Dysfunctional infertility;Traditional Chinese medical science task, endocrine disturbance is the performance of the deficiency of YIN, is that stagnation of QI-blood is caused, and congestion is trapped in body In, venation is obstructed, outer poison invasion, lochiostasis etc. all may cause stagnation of QI-blood, it is therefore desirable to makes QI and blood unobstructed, makes Essence and blood nourishes whole body, blood circulation promoting, and carrying out from inside to outside is nursed one's health comprehensively, treatment by Chinese herbs dyscrinic sterility and infertility Possess side effect little, bear painful little advantage, and can fundamentally nurse one's health health, pay attention to organic conception, pay attention to comprehensive control, Pay attention to dialectical treating, therapeutic effect more demonstrates clinical advantage, for these reasons, in the urgent need to research and development obstetrics and gynecology department In the Chinese medicine for the treatment of endocrine disturbance, with preferably treatment department of obstetrics and gynecology sterility and infertility patient.
Summary of the invention
It is an object of the invention to provide a kind of department of obstetrics and gynecology medicine treating endocrine disturbance and preparation method thereof, to solve The problem proposed in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of department of obstetrics and gynecology medicine treating endocrine disturbance, is made up according to the raw material of weight portion of following: Semen Cuscutae 10-20 Part, downy rosemyrtle root 15-25 part, Radix Angelicae Sinensis 50-60 part, Radix Pseudostellariae 50-60 part, Testis et penis callorhini 4-6 part, Testis Et penis Equi 2-6 part, Yunnan Caulis Spatholobi 2-10 Part, Rhizoma Corydalis 15-25 part, Herba Ecliptae 20-30 part, Semen Astragali Complanati 10-20 part, Herba Salviae Chinensis 2-4 part, Rhizoma Alpiniae Officinarum 4-8 part, Rhizoma Saururi (Herba Saururi) 10-20 part, Semen Ziziphi Spinosae 10-20 part, Herba Dianthi 15-25 part, Rhizoma Atractylodis Macrocephalae 10-15 part.
As the further scheme of the present invention: the department of obstetrics and gynecology medicine of described treatment endocrine disturbance, by following according to weight The raw material of part is made: Semen Cuscutae 12-18 part, downy rosemyrtle root 18-22 part, Radix Angelicae Sinensis 53-57 part, Radix Pseudostellariae 54-56 part, Testis et penis callorhini 4-6 Part, Testis Et penis Equi 3-4 part, Yunnan Caulis Spatholobi 4-8 part, Rhizoma Corydalis 18-22 part, Herba Ecliptae 23-27 part, Semen Astragali Complanati 13-17 part, Herba Salviae Chinensis 2- 4 parts, Rhizoma Alpiniae Officinarum 5-7 part, Rhizoma Saururi (Herba Saururi) 11-19 part, Semen Ziziphi Spinosae 14-16 part, Herba Dianthi 19-21 part, Rhizoma Atractylodis Macrocephalae 12-14 part.
As the present invention further scheme: the department of obstetrics and gynecology medicine of described treatment endocrine disturbance, by following according to weight The raw material of amount part is made: Semen Cuscutae 15 parts, downy rosemyrtle root 20 parts, Radix Angelicae Sinensis 55 parts, Radix Pseudostellariae 55 parts, Testis et penis callorhini 5 parts, Testis Et penis Equi 4 parts, Yunnan Caulis Spatholobi 6 parts, Rhizoma Corydalis 20 parts, Herba Ecliptae 25 parts, Semen Astragali Complanati 15 parts, Herba Salviae Chinensis 3 parts, Rhizoma Alpiniae Officinarum 6 parts, Rhizoma Saururi (Herba Saururi) 15 parts, acid Semen Ziziphi Spinosae 15 parts, Herba Dianthi 20 parts, the Rhizoma Atractylodis Macrocephalae 13 parts.
As the present invention further scheme: the preparation method of the department of obstetrics and gynecology medicine of described treatment endocrine disturbance, bag Include following steps:
1) weigh each raw material by formula, clean after drying standby;
2) by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Herba Ecliptae, Rhizoma Alpiniae Officinarum, Herba Dianthi, Semen Astragali Complanati mixing, 5-10 times of weight of mixture is added Water, decoct 2-4 time, each 2.5-4.5h, merging filtrate, filtrate concentrate drying, be ground into fine powder, standby;
3) Rhizoma Atractylodis Macrocephalae, Yunnan Caulis Spatholobi, Herba Salviae Chinensis, Rhizoma Corydalis, downy rosemyrtle root, Semen Cuscutae mixed and smash, then soaking 24-36h, filters, filtrate concentrate drying, is ground into fine powder standby;Filtering residue adds 75% soak with ethanol 6-12h, filters, and filtrate concentrates It is dried and is ground into fine powder, standby;
4) by Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi lyophilization, it is ground into fine powder, adds mixed-powder gross weight 5-9 times The rice wine airtight immersion 24-48h of 35-50 degree, filter, filtrate is standby;
5) by step 2) in fine powder and the step 3 of preparation) in the fine powder of preparation join step 4) filtrate in, stirring is all Even, after standing 3h, it is dried, obtains thick paste;
6) by step 5) in thick paste add adjuvant, make tablet, capsule, granule or electuary according to a conventional method.
As the present invention further scheme: described step 4) in, Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi freezing are done Dry, it is ground into fine powder, the rice wine airtight immersion 36h of add mixed-powder gross weight 7 times 42 degree, to filter, filtrate is standby.
In the present invention, the pharmacological action of each raw material is as follows:
1. Semen Cuscutae: sweet in the mouth, warm in nature;, return kidney,liver,spleen warp, there is nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal Effect;Clinic is mainly used in that lumbago due to renal deficiency, impotence and seminal emission, frequent micturition, cold womb be infertile, the kidney yin yang deficiency syndrome of the dark loose stool of mesh.
2. downy rosemyrtle root: sweet in the mouth, puckery;Property flat;Nourish blood, dredging collateral, hemostasis and pain-relieving;For chronic hepatitis, hernia, metrorrhagia, rheumatism Arthralgia pain, lumbar muscle strain.
3. Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature;Return liver, the heart, spleen channel;Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation;For blood deficiency Sallow, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation; Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow;For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
4. Radix Pseudostellariae: sweet in the mouth, micro-hardship;Property flat;Return spleen, lung meridian;Replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung;Tired for insufficiency of the spleen body, appetite Depressed, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
5. Testis et penis callorhini: sweet in the mouth, temperature, nontoxic greatly;Tonifying YANG YIN nourishing, kidney-supplementing liver-boosting, endocrine regulation;Its whip is put down, and enters liver and mends Kidney;Be applicable to because of sexual impotence, premature ejaculation, sexual disorder and the insomnia and dreamful sleep caused by the kidney deficiency such as damage of kidney-YIN, insufficiency of kidney-YANG, The diseases such as dizzy forgetful, soreness of waist and knee, neurasthenia and immunologic hypofunction;Blood yiqi, the hemoglobin in Testis et penis callorhini and blood Pigment content is high, it is adaptable to blood deficiency gas weak person;Skin care skin Caring, containing a large amount of viscous proteins in Testis et penis callorhini, has slow down aging, Keep elasticity of skin and the function of moisture.
6. Testis Et penis Equi: sweet in the mouth, temperature;Nontoxic;Strong muscle, bone strengthening, YIN nourishing flutters void;Control bone tuberculosis, bamboo marrow is scorching, blood deficiency gas is weak, women Hypogalactia.
7. Yunnan Caulis Spatholobi: bitter in the mouth, sweet;Warm in nature;Return liver, kidney channel;Blood circulation promoting and enriching, menstruction regulating and pain relieving, channels sootheing and network vessel quickening;For menstruation Uncomfortable, dysmenorrhea, paralysis and numbness, rheumatic arthralgia, deficient qi and blood.
8. Rhizoma Corydalis: acrid in the mouth, hardship;Warm in nature;Return liver, spleen channel;Invigorate blood circulation, circulation of qi promoting, pain relieving;For the breast side of body, epigastric pain, the thoracic obstruction Pained, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
9. Herba Ecliptae: sweet in the mouth acid, cool in nature;Enter Liver and kidney two warp, nontoxic;Nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, The diseases such as enterorrhagia;Smashing juice painting eyebrow to send out, can promote hair growth, for oral administration have black hair, hair color effect.
10. Semen Astragali Complanati: have the effect of tonifying the kidney to consolidate the essence, liver heat removing and eyesight improving, cures mainly soreness of waist and knee joint, seminal emission premature ejaculation, the enuresis, frequent micturition, white Band, neurasthenia and the disease such as visual deterioration, diabetes.
11. Herba Salviae Chinensiss: blood circulation promoting and blood stasis dispelling;Clearing away heat-damp and promoting diuresis;Mass dissipating and swelling eliminating.Main menoxenia;Dysmenorrhea;Amenorrhea;Metrorrhagia, has blood in stool; Jaundice due to damp-heat;Hot toxic-heat and blood stasis;Drench pain;Leukorrhagia;Rheumatic ostalgia;Scrofula;Skin ulcer swells;Acute mastitis;Herpes zoster;Leprosy;Traumatic injury wound is swollen.
12. Rhizoma Alpiniae Officinarums: acrid in the mouth, property heat;Return spleen, stomach warp;Stomach warming preventing or arresting vomiting, dispersing cold for relieving pain;For coldness and pain in the epigastrium, cold syndrome of the stomach is vomitted Tell, belch acid regurgitation.
13. Rhizoma Saururi (Herba Saururi)s: sweet in the mouth, pungent, cold in nature;Return lung, bladder warp;Inducing diuresis to remove edema, heat-clearing and toxic substances removing;Curing mainly edema, urine is not Profit, drenches and drips puckery pain, leukorrhagia;External treatment sore swollen toxin, eczema.
14. Semen Ziziphi Spinosaes: the Semen Ziziphi Spinosae i.e. seed of Ziziphi Spinosae, can make medicinal after concocting, and it contains alkaloid, several amino acids With the composition such as metallic element, the effects such as mind tranquilizing and the heart calming, invigorating middle warmer nourishing the liver, arresting sweating can be played, empty to restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, body The diseases such as spontaneous perspiration have preferable therapeutic effect.
15. Herba Dianthis: bitter in the mouth, cold in nature;GUIXIN, small intestine meridian;There is inducing diuresis for treating stranguria syndrome, effect of promoting blood circulation to restore menstrual flow;For pyretic stranguria, blood Drenching, stranguria caused by urinary stone, urinary obstruction, drench and drip puckery pain, the amenorrhea stasis of blood is cloudy.
16. Rhizoma Atractylodis Macrocephalaes: bitter in the mouth, sweet, warm in nature;Return spleen, stomach warp;Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive;For insufficiency of the spleen food Few, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement;Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive;For insufficiency of the spleen lack of appetite, let out Rush down loose stool, frequent fetal movement.
Compared with prior art, the invention has the beneficial effects as follows: the raw material that medicine is formed by the present invention carries out well-chosen, Can mutually synergism, work, play the pharmacological action of medicine to a greater extent;The medicine of the present invention is through each Synergism between crude drug, has invigorating qi and benefiting blood, nourishing liver, invigorating kidney, heat-clearing and toxic substances removing, enhancing immunity, dredge the meridian passage, Shu Jing Pain relieving, effect of profit stomach yin nourishing, may be used for treatment and the conditioning of Endocrine imbalance so that endocrine recovers normal, effectively Treat that the dysmenorrhea that causes because of endocrine disturbance, menstrual period are irregular, fatigue, sterility and infertility symptom, go back Endocrine imbalance and make The facial skin disease, the sexual disorder that become have good improvement and elimination effect;Instant effect, determined curative effect, have no side effect, There is treating both the principal and secondary aspects of a disease, short treating period, feature that drug cost is low, be worth being widely popularized in clinic.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.
Embodiment 1
A kind of department of obstetrics and gynecology medicine treating endocrine disturbance, is made up according to the raw material of weight portion of following: Semen Cuscutae 10 parts, Downy rosemyrtle root 15 parts, Radix Angelicae Sinensis 50 parts, Radix Pseudostellariae 50 parts, Testis et penis callorhini 4 parts, Testis Et penis Equi 2 parts, Yunnan Caulis Spatholobi 2 parts, Rhizoma Corydalis 15 parts, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) Grass 20 parts, Semen Astragali Complanati 10 parts, Herba Salviae Chinensis 2 parts, Rhizoma Alpiniae Officinarum 4 parts, Rhizoma Saururi (Herba Saururi) 10 parts, Semen Ziziphi Spinosae 10 parts, Herba Dianthi 15 parts, the Rhizoma Atractylodis Macrocephalae 10 Part.
The preparation method of the department of obstetrics and gynecology medicine of described treatment endocrine disturbance, comprises the following steps:
1) weigh each raw material by formula, clean after drying standby;
2) by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Herba Ecliptae, Rhizoma Alpiniae Officinarum, Herba Dianthi, Semen Astragali Complanati mixing, 5 times of weight of mixture are added Water, decocts 2 times, each 2.5h, merging filtrate, filtrate concentrate drying, is ground into fine powder, standby;
3) Rhizoma Atractylodis Macrocephalae, Yunnan Caulis Spatholobi, Herba Salviae Chinensis, Rhizoma Corydalis, downy rosemyrtle root, Semen Cuscutae mixed and smash, then soaking 24-36h, filters, filtrate concentrate drying, is ground into fine powder standby;Filtering residue adds 75% soak with ethanol 12h, filters, and filtrate concentrates dry Dry and be ground into fine powder, standby;
4) by Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi lyophilization, it is ground into fine powder, adds mixed-powder gross weight 5 times The rice wine airtight immersion 24h of 35 degree, filters, and filtrate is standby;
5) by step 2) in fine powder and the step 3 of preparation) in the fine powder of preparation join step 4) filtrate in, stirring is all Even, after standing 3h, it is dried, obtains thick paste;
6) by step 5) in thick paste add adjuvant, make tablet, capsule, granule or electuary according to a conventional method.
Embodiment 2
A kind of department of obstetrics and gynecology medicine treating endocrine disturbance, is made up according to the raw material of weight portion of following: Semen Cuscutae 20 parts, Downy rosemyrtle root 25 parts, Radix Angelicae Sinensis 60 parts, Radix Pseudostellariae 60 parts, Testis et penis callorhini 6 parts, Testis Et penis Equi 6 parts, Yunnan Caulis Spatholobi 10 parts, Rhizoma Corydalis 25 parts, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) Grass 30 parts, Semen Astragali Complanati 20 parts, Herba Salviae Chinensis 4 parts, Rhizoma Alpiniae Officinarum 8 parts, Rhizoma Saururi (Herba Saururi) 20 parts, Semen Ziziphi Spinosae 20 parts, Herba Dianthi 25 parts, the Rhizoma Atractylodis Macrocephalae 15 Part.
The preparation method of the department of obstetrics and gynecology medicine of described treatment endocrine disturbance, comprises the following steps:
1) weigh each raw material by formula, clean after drying standby;
2) by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Herba Ecliptae, Rhizoma Alpiniae Officinarum, Herba Dianthi, Semen Astragali Complanati mixing, 5-10 times of weight of mixture is added Water, decoct 4 times, each 4.5h, merging filtrate, filtrate concentrate drying, be ground into fine powder, standby;
3) Rhizoma Atractylodis Macrocephalae, Yunnan Caulis Spatholobi, Herba Salviae Chinensis, Rhizoma Corydalis, downy rosemyrtle root, Semen Cuscutae mixed and smash, then soaking 36h, filters, filtrate concentrate drying, is ground into fine powder standby;Filtering residue adds 75% soak with ethanol 12h, filters, filtrate concentrate drying And it is ground into fine powder, standby;
4) by Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi lyophilization, it is ground into fine powder, adds mixed-powder gross weight 5-9 times The rice wine airtight immersion 48h of 50 degree, filter, filtrate is standby;
5) by step 2) in fine powder and the step 3 of preparation) in the fine powder of preparation join step 4) filtrate in, stirring is all Even, after standing 3h, it is dried, obtains thick paste;
6) by step 5) in thick paste add adjuvant, make tablet, capsule, granule or electuary according to a conventional method.
Embodiment 3
A kind of department of obstetrics and gynecology medicine treating endocrine disturbance, is made up according to the raw material of weight portion of following: Semen Cuscutae 12 parts, Downy rosemyrtle root 18 parts, Radix Angelicae Sinensis 53 parts, Radix Pseudostellariae 54 parts, Testis et penis callorhini 4 parts, Testis Et penis Equi 3 parts, Yunnan Caulis Spatholobi 4 parts, Rhizoma Corydalis 18 parts, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) Grass 23 parts, Semen Astragali Complanati 13 parts, Herba Salviae Chinensis 2 parts, Rhizoma Alpiniae Officinarum 5 parts, Rhizoma Saururi (Herba Saururi) 11 parts, Semen Ziziphi Spinosae 14 parts, Herba Dianthi 19 parts, the Rhizoma Atractylodis Macrocephalae 12 Part.
The preparation method of the department of obstetrics and gynecology medicine of described treatment endocrine disturbance, comprises the following steps:
1) weigh each raw material by formula, clean after drying standby;
2) by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Herba Ecliptae, Rhizoma Alpiniae Officinarum, Herba Dianthi, Semen Astragali Complanati mixing, 6 times of weight of mixture are added Water, decocts 2 times, each 3h, merging filtrate, filtrate concentrate drying, is ground into fine powder, standby;
3) Rhizoma Atractylodis Macrocephalae, Yunnan Caulis Spatholobi, Herba Salviae Chinensis, Rhizoma Corydalis, downy rosemyrtle root, Semen Cuscutae mixed and smash, then soaking 28h, filters, filtrate concentrate drying, is ground into fine powder standby;Filtering residue adds 75% soak with ethanol 8h, filters, and filtrate concentrate drying is also It is ground into fine powder, standby;
4) by Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi lyophilization, it is ground into fine powder, adds mixed-powder gross weight 6 times The rice wine airtight immersion 32h of 40 degree, filters, and filtrate is standby;
5) by step 2) in fine powder and the step 3 of preparation) in the fine powder of preparation join step 4) filtrate in, stirring is all Even, after standing 3h, it is dried, obtains thick paste;
6) by step 5) in thick paste add adjuvant, make tablet, capsule, granule or electuary according to a conventional method.
Embodiment 4
A kind of department of obstetrics and gynecology medicine treating endocrine disturbance, is made up according to the raw material of weight portion of following: Semen Cuscutae 18 parts, Downy rosemyrtle root 22 parts, Radix Angelicae Sinensis 57 parts, Radix Pseudostellariae 56 parts, Testis et penis callorhini 6 parts, Testis Et penis Equi 4 parts, Yunnan Caulis Spatholobi 8 parts, Rhizoma Corydalis 22 parts, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) Grass 27 parts, Semen Astragali Complanati 17 parts, Herba Salviae Chinensis 4 parts, Rhizoma Alpiniae Officinarum 7 parts, Rhizoma Saururi (Herba Saururi) 19 parts, Semen Ziziphi Spinosae 16 parts, Herba Dianthi 21 parts, the Rhizoma Atractylodis Macrocephalae 14 Part.
The preparation method of the department of obstetrics and gynecology medicine of described treatment endocrine disturbance, comprises the following steps:
1) weigh each raw material by formula, clean after drying standby;
2) by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Herba Ecliptae, Rhizoma Alpiniae Officinarum, Herba Dianthi, Semen Astragali Complanati mixing, 9 times of weight of mixture are added Water, decocts 4 times, each 4h, merging filtrate, filtrate concentrate drying, is ground into fine powder, standby;
3) Rhizoma Atractylodis Macrocephalae, Yunnan Caulis Spatholobi, Herba Salviae Chinensis, Rhizoma Corydalis, downy rosemyrtle root, Semen Cuscutae mixed and smash, then soaking 32h, filters, filtrate concentrate drying, is ground into fine powder standby;Filtering residue adds 75% soak with ethanol 10h, filters, filtrate concentrate drying And it is ground into fine powder, standby;
4) by Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi lyophilization, it is ground into fine powder, adds mixed-powder gross weight 8 times The rice wine airtight immersion 40h of 45 degree, filters, and filtrate is standby;
5) by step 2) in fine powder and the step 3 of preparation) in the fine powder of preparation join step 4) filtrate in, stirring is all Even, after standing 3h, it is dried, obtains thick paste;
6) by step 5) in thick paste add adjuvant, make tablet, capsule, granule or electuary according to a conventional method.
Embodiment 5
A kind of department of obstetrics and gynecology medicine treating endocrine disturbance, is made up according to the raw material of weight portion of following: Semen Cuscutae 15 parts, Downy rosemyrtle root 20 parts, Radix Angelicae Sinensis 55 parts, Radix Pseudostellariae 55 parts, Testis et penis callorhini 5 parts, Testis Et penis Equi 4 parts, Yunnan Caulis Spatholobi 6 parts, Rhizoma Corydalis 20 parts, Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) Grass 25 parts, Semen Astragali Complanati 15 parts, Herba Salviae Chinensis 3 parts, Rhizoma Alpiniae Officinarum 6 parts, Rhizoma Saururi (Herba Saururi) 15 parts, Semen Ziziphi Spinosae 15 parts, Herba Dianthi 20 parts, the Rhizoma Atractylodis Macrocephalae 13 Part.
The preparation method of the department of obstetrics and gynecology medicine of described treatment endocrine disturbance, comprises the following steps:
1) weigh each raw material by formula, clean after drying standby;
2) by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Herba Ecliptae, Rhizoma Alpiniae Officinarum, Herba Dianthi, Semen Astragali Complanati mixing, 5-10 times of weight of mixture is added Water, decoct 34 times, each 3.5h, merging filtrate, filtrate concentrate drying, be ground into fine powder, standby;
3) Rhizoma Atractylodis Macrocephalae, Yunnan Caulis Spatholobi, Herba Salviae Chinensis, Rhizoma Corydalis, downy rosemyrtle root, Semen Cuscutae mixed and smash, then soaking 30h, filters, filtrate concentrate drying, is ground into fine powder standby;Filtering residue adds 75% soak with ethanol 10h, filters, filtrate concentrate drying And it is ground into fine powder, standby;
4) by Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi lyophilization, it is ground into fine powder, adds mixed-powder gross weight 79 times The rice wine airtight immersion 36h of 42 degree, filters, and filtrate is standby;
5) by step 2) in fine powder and the step 3 of preparation) in the fine powder of preparation join step 4) filtrate in, stirring is all Even, after standing 3h, it is dried, obtains thick paste;
6) by step 5) in thick paste add adjuvant, make tablet, capsule, granule or electuary according to a conventional method.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment party Formula, in the ken that one skilled in the relevant art is possessed, it is also possible on the premise of without departing from this patent objective Various changes can be made.

Claims (5)

1. the department of obstetrics and gynecology medicine treating endocrine disturbance, it is characterised in that be made up according to the raw material of weight portion of following: Tu SIZI 10-20 part, downy rosemyrtle root 15-25 part, Radix Angelicae Sinensis 50-60 part, Radix Pseudostellariae 50-60 part, Testis et penis callorhini 4-6 part, Testis Et penis Equi 2-6 part, Yunnan Caulis Spatholobi 2-10 part, Rhizoma Corydalis 15-25 part, Herba Ecliptae 20-30 part, Semen Astragali Complanati 10-20 part, Herba Salviae Chinensis 2-4 part, Rhizoma Alpiniae Officinarum 4-8 Part, Rhizoma Saururi (Herba Saururi) 10-20 part, Semen Ziziphi Spinosae 10-20 part, Herba Dianthi 15-25 part, Rhizoma Atractylodis Macrocephalae 10-15 part.
The department of obstetrics and gynecology medicine for the treatment of endocrine disturbance the most according to claim 1, it is characterised in that by following according to weight The raw material of part is made: Semen Cuscutae 12-18 part, downy rosemyrtle root 18-22 part, Radix Angelicae Sinensis 53-57 part, Radix Pseudostellariae 54-56 part, Testis et penis callorhini 4-6 Part, Testis Et penis Equi 3-4 part, Yunnan Caulis Spatholobi 4-8 part, Rhizoma Corydalis 18-22 part, Herba Ecliptae 23-27 part, Semen Astragali Complanati 13-17 part, Herba Salviae Chinensis 2- 4 parts, Rhizoma Alpiniae Officinarum 5-7 part, Rhizoma Saururi (Herba Saururi) 11-19 part, Semen Ziziphi Spinosae 14-16 part, Herba Dianthi 19-21 part, Rhizoma Atractylodis Macrocephalae 12-14 part.
The department of obstetrics and gynecology medicine for the treatment of endocrine disturbance the most according to claim 1, it is characterised in that by following according to weight The raw material of part is made: Semen Cuscutae 15 parts, downy rosemyrtle root 20 parts, Radix Angelicae Sinensis 55 parts, Radix Pseudostellariae 55 parts, Testis et penis callorhini 5 parts, Testis Et penis Equi 4 parts, Yunnan chicken Caulis seu Radix Schisandrae Henryi 6 parts, Rhizoma Corydalis 20 parts, Herba Ecliptae 25 parts, Semen Astragali Complanati 15 parts, Herba Salviae Chinensis 3 parts, Rhizoma Alpiniae Officinarum 6 parts, Rhizoma Saururi (Herba Saururi) 15 parts, Ziziphi Spinosae Core 15 parts, Herba Dianthi 20 parts, the Rhizoma Atractylodis Macrocephalae 13 parts.
4. a preparation method for the department of obstetrics and gynecology medicine of the treatment endocrine disturbance as described in claim 1-3 is arbitrary, its feature It is, comprises the following steps:
1) weigh each raw material by formula, clean after drying standby;
2) by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Herba Ecliptae, Rhizoma Alpiniae Officinarum, Herba Dianthi, Semen Astragali Complanati mixing, the water of 5-10 times of weight of mixture is added, Decoct 2-4 time, each 2.5-4.5h, merging filtrate, filtrate concentrate drying, be ground into fine powder, standby;
3) Rhizoma Atractylodis Macrocephalae, Yunnan Caulis Spatholobi, Herba Salviae Chinensis, Rhizoma Corydalis, downy rosemyrtle root, Semen Cuscutae mixed and smash, then soaking 24- 36h, filters, filtrate concentrate drying, is ground into fine powder standby;Filtering residue adds 75% soak with ethanol 6-12h, filters, and filtrate concentrates dry Dry and be ground into fine powder, standby;
4) by Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi lyophilization, it is ground into fine powder, adds the 35-of mixed-powder gross weight 5-9 times The rice wine airtight immersion 24-48h of 50 degree, filters, and filtrate is standby;
5) by step 2) in fine powder and the step 3 of preparation) in the fine powder of preparation join step 4) filtrate in, stir, After standing 3h, it is dried, obtains thick paste;
6) by step 5) in thick paste add adjuvant, make tablet, capsule, granule or electuary according to a conventional method.
The preparation method of the department of obstetrics and gynecology medicine for the treatment of endocrine disturbance the most according to claim 4, it is characterised in that described Step 4) in, by Radix Angelicae Sinensis, Radix Pseudostellariae, Testis et penis callorhini, Testis Et penis Equi lyophilization, it is ground into fine powder, adds the 42 of mixed-powder gross weight 7 times The rice wine airtight immersion 36h of degree, filters, and filtrate is standby.
CN201610763743.3A 2016-08-30 2016-08-30 A kind of department of obstetrics and gynecology medicine treating endocrine disturbance and preparation method thereof Pending CN106266889A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106924664A (en) * 2017-03-27 2017-07-07 袁晶 A kind of Chinese medicine composition for treating gynemetrics's endocrinopathy and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103977281A (en) * 2014-05-22 2014-08-13 张囡囡 Traditional Chinese medicine composition for treating female endocrine disorders and preparation method thereof
CN104491404A (en) * 2014-12-07 2015-04-08 杨美荣 Traditional Chinese medicine formula for treating endocrine dyscrasia
CN105770828A (en) * 2016-04-14 2016-07-20 刁力 Traditional Chinese medicine composition for treating endocrine dyscrasia and preparation method for traditional Chinese medicine composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103977281A (en) * 2014-05-22 2014-08-13 张囡囡 Traditional Chinese medicine composition for treating female endocrine disorders and preparation method thereof
CN104491404A (en) * 2014-12-07 2015-04-08 杨美荣 Traditional Chinese medicine formula for treating endocrine dyscrasia
CN105770828A (en) * 2016-04-14 2016-07-20 刁力 Traditional Chinese medicine composition for treating endocrine dyscrasia and preparation method for traditional Chinese medicine composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106924664A (en) * 2017-03-27 2017-07-07 袁晶 A kind of Chinese medicine composition for treating gynemetrics's endocrinopathy and preparation method thereof

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Application publication date: 20170104