CN105770828A - Traditional Chinese medicine composition for treating endocrine dyscrasia and preparation method for traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating endocrine dyscrasia and preparation method for traditional Chinese medicine composition Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses traditional Chinese medicine composition for treating endocrine dyscrasia and a preparation method for the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight through the processes of water boiling, alcohol extraction, soaking and the like: Chinese lizardtail rhizome or herb, semen ziziphi spinosae, rhizoma zingiberis, fructus choerospondiatis, fructus ligustri lucidi, fructus podophylli, semen persicae, folium nelumbinis, rhizoma belamcandae, radix puerariae thomsonii, bulbus fritillariae thunbergii, folium mori, herba dianthi, radix platycodonis, flos lonicerae and radix glycyrrhizae. According to the traditional Chinese medicine composition, 270 patients suffering from the endocrine dyscrasia are treated; the patients mainly have the symptoms of tinnitus, breast distending pain, painful menstruation, menstrual disorder, acnes, constipation and irascibility; the total effective rate reaches 96.7% through the treatment; the effect is remarkable; adverse reactions and toxic or side effects are not discovered, so that the traditional Chinese medicine composition is remarkable in curative effect for the endocrine dyscrasia and has good promotion values.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to a kind of treat endocrine disturbance Chinese medicine composition and preparation method thereof.
Background technology
Endocrine disturbance is a kind of relatively common problem, and each period in life occurs for it.Along with the life stress of modern constantly increases, endocrine disturbance personnel are also in rising trend year by year, the method treating endocrine disturbance at present has self regulation, Chinese traditional treatment, western medical treatment, but self regulation differs because of patient's Endocrine mastery of knowledge degree, and most people can not be conditioned；Doctor trained in Western medicine, for the different causes of disease, symptom and body constitution, the order of severity, has different countermeasures, mainly symptomatic treatment, but the drug side effect that doctor trained in Western medicine uses is relatively big, and is cure the symptoms, not the disease；Currently used treatment by Chinese herbs endocrine disturbance is also more, but effect is slow, and medicine time is long.
In order to solve the problems referred to above, the present inventor have developed Chinese medicine composition and the preparation method of a kind of new treatment endocrine disturbance.
Summary of the invention
It is an object of the invention to provide a kind of treat endocrine disturbance Chinese medicine composition.
The preparation method that it is a further object of the present invention to provide a kind of Chinese medicine composition treating endocrine disturbance.
The present invention provides a kind of Chinese medicine composition treating endocrine disturbance, and this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 50-100 part, Semen Ziziphi Spinosae 20-60 part, Rhizoma Zingiberis 10-40 part, Fructus Choerospondiatis 20-60 part, Fructus Ligustri Lucidi 10-40 part, Fructus Sinopodophylli 10-35 part, Semen Persicae 10-40 part, Folium Nelumbinis 10-30 part, Rhizoma Belamcandae 10-45 part, Pachyrhizua angulatus 10-45 part, Bulbus Fritillariae Thunbergii 20-60 part, Folium Mori 10-30 part, Herba Dianthi 20-50 part, Radix Platycodonis 10-35 part, Flos Lonicerae 15-45 part, Radix Glycyrrhizae 10-30 part.
Preferably, the Chinese medicine composition of the present invention is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 55-95 part, Semen Ziziphi Spinosae 25-55 part, Rhizoma Zingiberis 15-35 part, Fructus Choerospondiatis 25-55 part, Fructus Ligustri Lucidi 15-35 part, Fructus Sinopodophylli 15-30 part, Semen Persicae 15-35 part, Folium Nelumbinis 12-28 part, Rhizoma Belamcandae 15-40 part, Pachyrhizua angulatus 15-40 part, Bulbus Fritillariae Thunbergii 25-55 part, Folium Mori 15-25 part, Herba Dianthi 25-45 part, Radix Platycodonis 15-30 part, Flos Lonicerae 20-40 part, Radix Glycyrrhizae 15-25 part.
It is further preferred that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 60-90 part, Semen Ziziphi Spinosae 30-50 part, Rhizoma Zingiberis 20-30 part, Fructus Choerospondiatis 30-50 part, Fructus Ligustri Lucidi 20-30 part, Fructus Sinopodophylli 18-28 part, Semen Persicae 18-32 part, Folium Nelumbinis 15-25 part, Rhizoma Belamcandae 20-35 part, Pachyrhizua angulatus 20-35 part, Bulbus Fritillariae Thunbergii 30-50 part, Folium Mori 18-22 part, Herba Dianthi 28-42 part, Radix Platycodonis 18-28 part, Flos Lonicerae 22-38 part, Radix Glycyrrhizae 18-22 part.
Further preferred, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 65-85 part, Semen Ziziphi Spinosae 35-45 part, Rhizoma Zingiberis 22-28 part, Fructus Choerospondiatis 35-45 part, Fructus Ligustri Lucidi 22-28 part, Fructus Sinopodophylli 20-26 part, Semen Persicae 20-30 part, Folium Nelumbinis 18-22 part, Rhizoma Belamcandae 22-32 part, Pachyrhizua angulatus 22-32 part, Bulbus Fritillariae Thunbergii 35-45 part, Folium Mori 19-21 part, Herba Dianthi 30-40 part, Radix Platycodonis 20-26 part, Flos Lonicerae 25-35 part, Radix Glycyrrhizae 19-21 part.
Further preferred, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 70 parts, Semen Ziziphi Spinosae 40 parts, Rhizoma Zingiberis 25 parts, Fructus Choerospondiatis 40 parts, Fructus Ligustri Lucidi 25 parts, Fructus Sinopodophylli 25 parts, 25 parts of Semen Persicae, 20 parts of Folium Nelumbinis, Rhizoma Belamcandae 28 parts, Pachyrhizua angulatus 28 parts, Bulbus Fritillariae Thunbergii 40 parts, 20 parts of Folium Mori, Herba Dianthi 35 parts, Radix Platycodonis 25 parts, Flos Lonicerae 30 parts, 20 parts of Radix Glycyrrhizae.
Chinese medicine composition of the present invention is possibly together with pharmaceutically acceptable carrier or diluent.
Chinese medicine composition of the present invention is solid preparation or liquid preparation, and described solid preparation is tablet, capsule, granule or pill；Described liquid preparation is oral liquid.
The preparation method of Chinese medicine composition of the present invention comprises the following steps: Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, Fructus Ligustri Lucidi, Fructus Sinopodophylli, Semen Persicae, Folium Nelumbinis, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Folium Mori, Herba Dianthi, Radix Platycodonis, Flos Lonicerae, Radix Glycyrrhizae are pulverized and sieved, uniform with pharmaceutically acceptable carrier or mixing diluents, prepare into preparation.
The preparation method of Chinese medicine composition of the present invention comprises the following steps:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 5-10 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 2-5 time, each 2-4 hour, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 10-20 hour, filter, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds soak with ethanol 3-6 hour of 60-90%, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add that the rice wine of the 35-50 degree of 5-10 times amount is airtight to be soaked 20-40 hour, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 2-4 hour, dry, addition adjuvant, make required dosage form.
Preferably, the preparation method of Chinese medicine composition of the present invention comprises the following steps:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 8 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 3 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 15 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 75% 4 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 30 hours of 45 degree of 8 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 3 hours, dry, addition adjuvant, make required dosage form.
Described parts by weight can be the known unit of weights of field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose；
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide, Pulvis Talci or magnesium stearate；
Described surfactant is smooth selected from dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fatty acid Pyrusussuriensis or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The Chinese medicine composition for the treatment of endocrine disturbance provided by the invention has the advantage that
Test group treatment endocrine disturbance 270 example, patient's main manifestations is tinnitus, distending pain of the breast, dysmenorrhea, menoxenia, acne, constipation, short-tempered., reaching 96.7% by treating total effective rate, effect is obvious, and does not find untoward reaction and toxic and side effects, illustrates that traditional Chinese medicine composition for treating endocrine disturbance of the present invention is evident in efficacy, has good promotional value.
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: Rhizoma Saururi (Herba Saururi) 50g, Semen Ziziphi Spinosae 20g, Rhizoma Zingiberis 10g, Fructus Choerospondiatis 20g, Fructus Ligustri Lucidi 10g, Fructus Sinopodophylli 10g, Semen Persicae 10g, Folium Nelumbinis 10g, Rhizoma Belamcandae 10g, Pachyrhizua angulatus 10g, Bulbus Fritillariae Thunbergii 20g, Folium Mori 10g, Herba Dianthi 20g, Radix Platycodonis 10g, Flos Lonicerae 15g, Radix Glycyrrhizae 10g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 5 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 2 times, each 2 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 10 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 60% 3 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 20 hours of 35 degree of 5 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 2 hours, dry, make fine powder, add the starch accounting for fine powder weight 2/5, mix homogeneously, loading capsule, make capsule.
Embodiment 2
Prescription: Rhizoma Saururi (Herba Saururi) 100g, Semen Ziziphi Spinosae 60g, Rhizoma Zingiberis 40g, Fructus Choerospondiatis 60g, Fructus Ligustri Lucidi 40g, Fructus Sinopodophylli 35g, Semen Persicae 40g, Folium Nelumbinis 30g, Rhizoma Belamcandae 45g, Pachyrhizua angulatus 45g, Bulbus Fritillariae Thunbergii 60g, Folium Mori 30g, Herba Dianthi 50g, Radix Platycodonis 35g, Flos Lonicerae 45g, Radix Glycyrrhizae 30g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 10 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 5 times, each 4 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 20 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 90% 6 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 40 hours of 50 degree of 10 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 4 hours, dry, make fine powder, addition accounts for the starch of fine powder weight 2/5, mix homogeneously, tabletting, makes tablet.
Embodiment 3
Prescription: Rhizoma Saururi (Herba Saururi) 95g, Semen Ziziphi Spinosae 55g, Rhizoma Zingiberis 35g, Fructus Choerospondiatis 55g, Fructus Ligustri Lucidi 35g, Fructus Sinopodophylli 30g, Semen Persicae 35g, Folium Nelumbinis 28g, Rhizoma Belamcandae 40g, Pachyrhizua angulatus 40g, Bulbus Fritillariae Thunbergii 55g, Folium Mori 25g, Herba Dianthi 45g, Radix Platycodonis 30g, Flos Lonicerae 40g, Radix Glycyrrhizae 25g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 8 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 4 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 18 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 80% 5 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 38 hours of 45 degree of 8 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 3 hours, add the starch accounting for fine powder weight 1/5, mix homogeneously, granulate, dry, make granule.
Embodiment 4
Prescription: Rhizoma Saururi (Herba Saururi) 55g, Semen Ziziphi Spinosae 25g, Rhizoma Zingiberis 15g, Fructus Choerospondiatis 25g, Fructus Ligustri Lucidi 15g, Fructus Sinopodophylli 15g, Semen Persicae 15g, Folium Nelumbinis 12g, Rhizoma Belamcandae 15g, Pachyrhizua angulatus 15g, Bulbus Fritillariae Thunbergii 25g, Folium Mori 15g, Herba Dianthi 25g, Radix Platycodonis 15g, Flos Lonicerae 20g, Radix Glycyrrhizae 15g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 6 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 3 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 12 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 75% 4 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 25 hours of 40 degree of 7 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 3 hours, dry, make fine powder, add the starch accounting for fine powder weight 2/5, mix homogeneously, loading capsule, make capsule.
Embodiment 5
Prescription: Rhizoma Saururi (Herba Saururi) 60g, Semen Ziziphi Spinosae 30g, Rhizoma Zingiberis 20g, Fructus Choerospondiatis 30g, Fructus Ligustri Lucidi 20g, Fructus Sinopodophylli 18g, Semen Persicae 18g, Folium Nelumbinis 15g, Rhizoma Belamcandae 20g, Pachyrhizua angulatus 20g, Bulbus Fritillariae Thunbergii 30g, Folium Mori 18g, Herba Dianthi 28g, Radix Platycodonis 18g, Flos Lonicerae 22g, Radix Glycyrrhizae 18g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 7 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 4 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 16 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 75% 4 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 25 hours of the 40a degree of 8 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 2-4 hour, dry, make fine powder, add the starch accounting for fine powder weight 2/5, mix homogeneously, loading capsule, make capsule.
Embodiment 6
Prescription: Rhizoma Saururi (Herba Saururi) 90g, Semen Ziziphi Spinosae 50g, Rhizoma Zingiberis 30g, Fructus Choerospondiatis 50g, Fructus Ligustri Lucidi 30g, Fructus Sinopodophylli 28g, Semen Persicae 32g, Folium Nelumbinis 25g, Rhizoma Belamcandae 35g, Pachyrhizua angulatus 35g, Bulbus Fritillariae Thunbergii 50g, Folium Mori 22g, Herba Dianthi 42g, Radix Platycodonis 28g, Flos Lonicerae 38g, Radix Glycyrrhizae 22g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 9 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 4 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 16 hours, filter, filtrate concentrate drying, be ground into fine powder standby；Filtering residue add 75% soak with ethanol 3-6 hour, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 30 hours of 45 degree of 9 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 2-4 hour, dry, make fine powder, add the starch accounting for fine powder weight 2/5, mix homogeneously, loading capsule, make capsule.
Embodiment 7
Prescription: Rhizoma Saururi (Herba Saururi) 65g, Semen Ziziphi Spinosae 35g, Rhizoma Zingiberis 22g, Fructus Choerospondiatis 35g, Fructus Ligustri Lucidi 22g, Fructus Sinopodophylli 20g, Semen Persicae 20g, Folium Nelumbinis 18g, Rhizoma Belamcandae 22g, Pachyrhizua angulatus 22g, Bulbus Fritillariae Thunbergii 35g, Folium Mori 19g, Herba Dianthi 30g, Radix Platycodonis 20g, Flos Lonicerae 25g, Radix Glycyrrhizae 19g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 8 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 3 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 15 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 75% 4 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 30 hours of 45 degree of 8 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 3 hours, dry, make fine powder, add the starch accounting for fine powder weight 2/5, mix homogeneously, loading capsule, make capsule.
Embodiment 8
Prescription: Rhizoma Saururi (Herba Saururi) 85g, Semen Ziziphi Spinosae 45g, Rhizoma Zingiberis 28g, Fructus Choerospondiatis 45g, Fructus Ligustri Lucidi 28g, Fructus Sinopodophylli 26g, Semen Persicae 30g, Folium Nelumbinis 22g, Rhizoma Belamcandae 32g, Pachyrhizua angulatus 32g, Bulbus Fritillariae Thunbergii 45g, Folium Mori 21g, Herba Dianthi 40g, Radix Platycodonis 26g, Flos Lonicerae 35g, Radix Glycyrrhizae 21g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 8 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 3 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 15 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 75% 4 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 30 hours of 45 degree of 8 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 3 hours, dry, make fine powder, add the starch accounting for fine powder weight 2/5, mix homogeneously, loading capsule, make capsule.
Embodiment 9
Prescription: Rhizoma Saururi (Herba Saururi) 70g, Semen Ziziphi Spinosae 40g, Rhizoma Zingiberis 25g, Fructus Choerospondiatis 40g, Fructus Ligustri Lucidi 25g, Fructus Sinopodophylli 25g, Semen Persicae 25g, Folium Nelumbinis 20g, Rhizoma Belamcandae 28g, Pachyrhizua angulatus 28g, Bulbus Fritillariae Thunbergii 40g, Folium Mori 20g, Herba Dianthi 35g, Radix Platycodonis 25g, Flos Lonicerae 30g, Radix Glycyrrhizae 20g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 8 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 3 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 15 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 75% 4 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 30 hours of 45 degree of 8 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 3 hours, dry, make fine powder, add the starch accounting for fine powder weight 2/5, mix homogeneously, loading capsule, make capsule.
The beneficial effect of of the present invention medicine is expanded on further below by way of clinical case.
1, case source
From volunteer, randomly select 270 female incretion patients test, age is between 18-55 year, sick time is between 1-9, and average 4 years, patient clinical symptom was: tinnitus, distending pain of the breast, dysmenorrhea, menoxenia, acne, constipation, short-tempered.
2, Therapeutic Method
Above-mentioned patient is equally divided into 9 groups, there was no significant difference between each group, these 9 groups of patients are taken respectively the medicine of embodiment of the present invention 1-9, one day 3 times, each 2g, takes 4 weeks continuously.
3, criterion of therapeutical effect
Effective: tinnitus, distending pain of the breast, dysmenorrhea, menoxenia, acne, constipation, short-tempered.Substantially disappear etc. each clinical symptoms；
Effective: tinnitus, distending pain of the breast, dysmenorrhea, menoxenia, acne, constipation, short-tempered.Taking an evident turn for the better etc. each clinical symptoms, endocrine disturbance makes moderate progress；
Invalid: endocrine disturbance, each clinical symptoms are without improvement.
Clinical recovery: endocrine manifestations all disappears, endocrine recovers normal.
4, experimental result
Most patients is using medicine within about 10 days, to have an obvious sensation according to the inventive method, tinnitus, distending pain of the breast, dysmenorrhea, menoxenia, acne, constipation, short-tempered improves.According to statistics, 270 example patients effect after using medicine of the present invention 4 weeks is in Table 1, and not easily recurs.
Table 1 curative effect statistical table
| Group | Clinical recovery | Effective | Effectively | Invalid | Add up to | Effective percentage (%) |
| Embodiment 1 | 15 | 4 | 10 | 1 | 30 | 96.7% |
| Embodiment 2 | 13 | 5 | 10 | 2 | 30 | 93.3% |
| Embodiment 3 | 15 | 7 | 7 | 1 | 30 | 96.7% |
| Embodiment 4 | 14 | 6 | 10 | 0 | 30 | 100% |
| Embodiment 5 | 13 | 10 | 6 | 1 | 30 | 96.7% |
| Embodiment 6 | 15 | 11 | 3 | 1 | 30 | 96.7% |
| Embodiment 7 | 15 | 10 | 3 | 2 | 30 | 93.3% |
| Embodiment 8 | 16 | 8 | 5 | 1 | 30 | 96.7% |
| Embodiment 9 | 17 | 9 | 4 | 0 | 30 | 100% |
Test group treatment endocrine disturbance 270 example, total effective rate reaches 96.7%, and effect is obvious, and does not find untoward reaction and toxic and side effects, illustrates that traditional Chinese medicine composition for treating endocrine disturbance of the present invention is evident in efficacy, has good promotional value.
Although, above use generality explanation, detailed description of the invention and test, the present invention is described in detail, but on basis of the present invention, it is possible to it being made some amendments or improves, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (10)
1. the Chinese medicine composition treating endocrine disturbance, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 50-100 part, Semen Ziziphi Spinosae 20-60 part, Rhizoma Zingiberis 10-40 part, Fructus Choerospondiatis 20-60 part, Fructus Ligustri Lucidi 10-40 part, Fructus Sinopodophylli 10-35 part, Semen Persicae 10-40 part, Folium Nelumbinis 10-30 part, Rhizoma Belamcandae 10-45 part, Pachyrhizua angulatus 10-45 part, Bulbus Fritillariae Thunbergii 20-60 part, Folium Mori 10-30 part, Herba Dianthi 20-50 part, Radix Platycodonis 10-35 part, Flos Lonicerae 15-45 part, Radix Glycyrrhizae 10-30 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 55-95 part, Semen Ziziphi Spinosae 25-55 part, Rhizoma Zingiberis 15-35 part, Fructus Choerospondiatis 25-55 part, Fructus Ligustri Lucidi 15-35 part, Fructus Sinopodophylli 15-30 part, Semen Persicae 15-35 part, Folium Nelumbinis 12-28 part, Rhizoma Belamcandae 15-40 part, Pachyrhizua angulatus 15-40 part, Bulbus Fritillariae Thunbergii 25-55 part, Folium Mori 15-25 part, Herba Dianthi 25-45 part, Radix Platycodonis 15-30 part, Flos Lonicerae 20-40 part, Radix Glycyrrhizae 15-25 part.
3. Chinese medicine composition according to claim 2, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 60-90 part, Semen Ziziphi Spinosae 30-50 part, Rhizoma Zingiberis 20-30 part, Fructus Choerospondiatis 30-50 part, Fructus Ligustri Lucidi 20-30 part, Fructus Sinopodophylli 18-28 part, Semen Persicae 18-32 part, Folium Nelumbinis 15-25 part, Rhizoma Belamcandae 20-35 part, Pachyrhizua angulatus 20-35 part, Bulbus Fritillariae Thunbergii 30-50 part, Folium Mori 18-22 part, Herba Dianthi 28-42 part, Radix Platycodonis 18-28 part, Flos Lonicerae 22-38 part, Radix Glycyrrhizae 18-22 part.
4. Chinese medicine composition according to claim 3, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 65-85 part, Semen Ziziphi Spinosae 35-45 part, Rhizoma Zingiberis 22-28 part, Fructus Choerospondiatis 35-45 part, Fructus Ligustri Lucidi 22-28 part, Fructus Sinopodophylli 20-26 part, Semen Persicae 20-30 part, Folium Nelumbinis 18-22 part, Rhizoma Belamcandae 22-32 part, Pachyrhizua angulatus 22-32 part, Bulbus Fritillariae Thunbergii 35-45 part, Folium Mori 19-21 part, Herba Dianthi 30-40 part, Radix Platycodonis 20-26 part, Flos Lonicerae 25-35 part, Radix Glycyrrhizae 19-21 part.
5. Chinese medicine composition according to claim 4, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Saururi (Herba Saururi) 70 parts, Semen Ziziphi Spinosae 40 parts, Rhizoma Zingiberis 25 parts, Fructus Choerospondiatis 40 parts, Fructus Ligustri Lucidi 25 parts, Fructus Sinopodophylli 25 parts, 25 parts of Semen Persicae, 20 parts of Folium Nelumbinis, Rhizoma Belamcandae 28 parts, Pachyrhizua angulatus 28 parts, Bulbus Fritillariae Thunbergii 40 parts, 20 parts of Folium Mori, Herba Dianthi 35 parts, Radix Platycodonis 25 parts, Flos Lonicerae 30 parts, 20 parts of Radix Glycyrrhizae.
6. the Chinese medicine composition according to any one of claim 1-5, it is characterised in that this Chinese medicine composition is possibly together with pharmaceutically acceptable carrier or diluent.
7. Chinese medicine composition according to claim 6, it is characterised in that described Chinese medicine composition is solid preparation or liquid preparation, described solid preparation is tablet, capsule, granule or pill；Described liquid preparation is oral liquid.
8. prepare the method for Chinese medicine composition described in any one of claim 1-5 for one kind, it is characterized in that, the method comprises the following steps: Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, Fructus Ligustri Lucidi, Fructus Sinopodophylli, Semen Persicae, Folium Nelumbinis, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Folium Mori, Herba Dianthi, Radix Platycodonis, Flos Lonicerae, Radix Glycyrrhizae are pulverized and sieved, uniform with pharmaceutically acceptable carrier or mixing diluents, prepare into preparation.
9. prepare the method for Chinese medicine composition described in any one of claim 1-5 for one kind, it is characterised in that the method comprises the following steps:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 5-10 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 2-5 time, each 2-4 hour, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 10-20 hour, filter, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds soak with ethanol 3-6 hour of 60-90%, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add that the rice wine of the 35-50 degree of 5-10 times amount is airtight to be soaked 20-40 hour, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 2-4 hour, dry, addition adjuvant, make required dosage form.
10. the preparation method of Chinese medicine composition according to claim 9, it is characterised in that the method comprises the following steps:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) add water 8 times amount by Rhizoma Saururi (Herba Saururi), Semen Ziziphi Spinosae, Rhizoma Zingiberis, Fructus Choerospondiatis, decocts 3 times, each 3 hours, collecting decoction, filters, filtrate concentrate drying, be ground into fine powder, standby；
3) Fructus Ligustri Lucidi, Semen Persicae, Rhizoma Belamcandae, Pachyrhizua angulatus, Bulbus Fritillariae Thunbergii, Herba Dianthi, Radix Platycodonis, Radix Glycyrrhizae are soaked 15 hours, filter, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol that filtering residue adds 75% 4 hours, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) Fructus Sinopodophylli, Folium Nelumbinis, Folium Mori, Flos Lonicerae are dried and crushed into fine powder, add the airtight immersion of rice wine 30 hours of 45 degree of 8 times amount, filter, and filtrate is standby；
5) by step 2), 3) standby fine powder adds step 4) filtrate in, stir, place 3 hours, dry, addition adjuvant, make required dosage form.
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|---|---|---|---|---|
| CN1091963A (en) * | 1993-03-08 | 1994-09-14 | 董冬海 | Freckle-removing beauty drug |
| CN104107395A (en) * | 2014-07-24 | 2014-10-22 | 王浩 | Traditional Chinese medicine composition for treating endocrine dyscrasia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091963A (en) * | 1993-03-08 | 1994-09-14 | 董冬海 | Freckle-removing beauty drug |
| CN104107395A (en) * | 2014-07-24 | 2014-10-22 | 王浩 | Traditional Chinese medicine composition for treating endocrine dyscrasia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106266889A (en) * | 2016-08-30 | 2017-01-04 | 孙婧 | A kind of department of obstetrics and gynecology medicine treating endocrine disturbance and preparation method thereof |
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