CN106262764B - 天然澄清剂及其应用 - Google Patents
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Abstract
本发明公开了一种天然澄清剂及其应用,该天然澄清剂包括A组份和B组份,所述A组份包含15~65%wt海藻酸丙二醇酯、5~50%wt海藻酸钠、20~45%wt膨润土;所述B组份包含25~85%wt壳聚糖、15~75%wt卡拉胶。本发明天然澄清剂主要去除鞣质、蛋白、蜡质等胶体不稳定成份,比传统澄清剂快2~5倍,安全无毒、不影响其他有效成份、不引入异味、不残留、不必调整待处理溶液的pH、不需要专用设备,特别适用于中草药制备,代替乙醇用于中草药提取的中间澄清过程,不仅性能优于乙醇,而且生产成本可降低50%以上。
Description
技术领域
本发明涉及生物制剂中澄清技术领域,具体地指一种天然澄清剂及其应用。
背景技术
目前市场上生物制备的澄清方法很多,传统方法常采用单宁+明胶或单宁+蛋清粉的方法进行澄清,去除其中的浑浊物,但是蛋清粉、明胶等物质属于一种过敏原物质,添加后,液体中存在残留物,难以分离,一旦残留了这些成分,会增加过敏的风险。溶液放置期间出现变质、犯浑、后期存放不稳定、澄清效果不佳等现象。加上制作工艺繁琐,对设备要求高,生产成本高等因素。
因此,天然澄清剂可代替醇沉工艺,简化工艺缩短生产周期和降低生产成本50%以上,澄清效率高,适用范围广。其主要采用“1+1技术”两组相互协同作用,通过再“架桥”以保证游离或结合的组份从酒液中分离而除去。
发明内容
本发明的目的就是要克服传统澄清技术在稳定性、效果和成本方面的不足,提供一种澄清速度快、效果好、不影响被澄清溶液有效成分的安全的天然澄清剂及其应用。
为实现上述目的,本发明所提供的天然澄清剂,包括A组份和B组份,其特征在于:
所述A组份包含15~65%wt海藻酸丙二醇酯、5~50%wt海藻酸钠、20~45%wt膨润土;
所述B组份包含25~85%wt壳聚糖、15~75%wt卡拉胶。
优选地,上述方案中所述A组份包含32~55%wt海藻酸丙二醇酯、16~38%wt海藻酸钠、28~35%wt膨润土。
优选地,上述方案中所述B组份包含36~75%wt壳聚糖、25~64%wt卡拉胶。
更优选地,上述方案中所述A组份包含37%wt海藻酸丙二醇酯、35%wt海藻酸钠、28%wt膨润土。
更优选地,上述方案中所述B组份包含65%wt壳聚糖、35%wt卡拉胶。
本发明还提供了一种上述天然澄清剂的使用方法,其中待澄清液体中A组份的添加量为200~800ppm,B组份的添加量也为200~800ppm。
本发明还具体提供了一种上述天然澄清剂的使用方法,其步骤如下:
1)将A组份用水稀释并使其充分溶胀,过滤得到浓度0.5~1%w/v的粘胶液A;
将B组份用0.6~1.3%v/v醋酸稀释并使其充分溶胀,过滤得到浓度0.5~1%w/v的粘胶液B;
2)测定待澄清液体的pH值,当pH值≤4.8时,先加入粘胶液A,稍搅拌见溶液明显变浑或小的絮状物后,再加入粘胶液B,使待澄清液体内有明显的絮状物,上清液透明,无乳光;
当pH值>4.8时,先加入粘胶液B,稍搅拌见溶液明显变浑或小的絮状物后,再加入粘胶液A,使待澄清液体内有明显的絮状物,上清液透明,无乳光;
3)将包含有絮状物的待澄清液体静置分离或离心分离,过滤得到澄清液体。
优选地,所述步骤1)为,将A组份用水稀释并使其充分溶胀,过滤得到浓度1%w/v的粘胶液A;
将B组份用1%v/v醋酸稀释并使其充分溶胀,过滤得到浓度1%w/v的粘胶液B。
本品系从食品中提取的天然高分子物质,以天然多糖等为原料,经科学工艺技术制作而成的纯天然碳水化合物类复合澄清剂,主要作用于食品、保健品等制备的澄清分离工艺。可广泛用于啤酒、酱油、食醋、果蔬饮料、糖液、发酵液、天然产物提取液、中草药提取液、营养液、口服液等的絮凝澄清。
本发明的有益效果:
(1)高效:天然澄清剂采用最新“1+1”澄清技术,一组份起主絮凝作用,另一组份则起辅助絮凝作用,因而大大加快了澄清过程,比传统澄清剂快2~5倍。
(2)不影响有效成份:天然澄清剂主要去除鞣质、蛋白、蜡质等胶体不稳定成份,对中草药有效成份如黄酮、生物碱、甙类、皂甙类、萜类、多糖、氨基酸、多肽、维生素、矿物质等不影响。对胶体不稳定成份的一步清除率在70%左右,二步清除率在90%以上,因此特别适用于中草药制备,代替醇沉工艺,用于口服液、冲剂、洗剂、注射剂、胶囊等制备。
(3)不需调整pH值:应用天然澄清剂,无需调整待处理溶液的pH,只需根据不同性质的待处理液选择不同的添加顺序和添加量,便可获得良好的澄清效果,使用非常方便。
(4)不引入异味:天然澄清剂为天然食品提取物,不引入异味,对某些带有异味的营养液还有一定的矫味作用。
(5)不残留:天然澄清剂,由于采用“1+1”澄清技术,第二种组份比第一种组份加入量少,第二种组份的再“架桥”作用可以保证游离或结合的第一种组份从溶液中分离而除去。
(6)安全无毒:天然澄清剂,系从食品中提取出的天然高分子物质,安全,卫生。
(7)使用方便:天然澄清剂,使用非常方便,无需添加设备,更改工艺流程,只需按顺序加入两种组份,便可见明显的絮状物出现,静置4~6小时即可分层,若配合管式离心机可即时分离出澄清流体。
(8)热稳定性好:加入澄清剂后加温至80摄氏度左右10~20分钟,澄清效果会更好,澄清后的成品可以耐受高温消毒。
(9)费用低廉:天然澄清剂代替乙醇用于中草药提取的中间澄清过程,不仅性能优于乙醇,而且生产成本可降低50%以上。
具体实施方式
以下结合具体实施例对本发明作进一步的详细描述。
一、天然澄清剂
实施例1
天然澄清剂1,其成分如下:
A组份中各成分及配比:15%海藻酸丙二醇酯、45%海藻酸钠、40%膨润土;
B组份中各成分及配比:25%壳聚糖、75%卡拉胶。
实施例2
天然澄清剂2,其成分如下:
A组份中各成分及配比:65%海藻酸丙二醇酯、15%海藻酸钠、20%膨润土;
B组份中各成分及配比:85%壳聚糖、15%卡拉胶。
实施例3
天然澄清剂3,其成分如下:
A组份中各成分及配比:50%海藻酸丙二醇酯、5%海藻酸钠、45%膨润土;
B组份中各成分及配比:32%壳聚糖、68%卡拉胶。
实施例4
天然澄清剂4,其成分如下:
A组份中各成分及配比:25%海藻酸丙二醇酯、50%海藻酸钠、25%膨润土;
B组份中各成分及配比:80%壳聚糖、20%卡拉胶。
实施例5
天然澄清剂5,其成分如下:
A组份中各成分及配比:32%海藻酸丙二醇酯、38%海藻酸钠、30%膨润土;
B组份中各成分及配比:36%壳聚糖、64%卡拉胶。
实施例6
天然澄清剂6,其成分如下:
A组份中各成分及配比:49%海藻酸丙二醇酯、16%海藻酸钠、35%膨润土;
B组份中各成分及配比:75%壳聚糖、25%卡拉胶。
实施例7
天然澄清剂7,其成分如下:
A组份中各成分及配比:55%海藻酸丙二醇酯、17%海藻酸钠、28%膨润土;
B组份中各成分及配比:50%壳聚糖、50%卡拉胶。
实施例8
天然澄清剂8,其成分如下:
A组份中各成分及配比:40%海藻酸丙二醇酯、30%海藻酸钠、30%膨润土;
B组份中各成分及配比:60%壳聚糖、40%卡拉胶。
实施例9
天然澄清剂9,其成分如下:
A组份中各成分及配比:37%海藻酸丙二醇酯、35%海藻酸钠、28%膨润土;
B组份中各成分及配比:65%壳聚糖、35%卡拉胶。
实施例10
上述实施例在应用时采用如下步骤:
1、天然澄清剂的稀释
将A组份和B组份分别加水配制成1%w/v粘胶液A和1%w/v粘胶液B。A、B组份均为淡黄色或灰白色粉末,具体配制方法为如下:
A组份:先用少量水溶解A组份搅成糊状,然后加入需要量的水,溶胀24小时,搅拌,用双层纱布过滤,即得1%w/v的粘胶液A。
B组份:先配制1%v/v的醋酸,然后用少量1%v/v醋酸溶解B组份并搅成糊状,再加入足够量的1%v/v醋酸,溶胀24小时,用双层纱布过滤,即得1%w/v的粘胶液B。
需要说明的是,配制的醋酸为稀醋酸浓度在0.6~1.3%v/v均可,用来溶解稀释B组份粘胶液A、B的浓度也仅为举例,视待澄清样品的情况,可以配制0.5~1%w/v浓度的。
二、天然澄清剂的使用
1.加样
1.1加养温度:
一般情况下,A、B组份的加样温度为50~70℃。个别品种需在室温下加料
1.1加样顺序:
一般原则,在pH值≤4.8环境中,按先粘胶液A后粘胶液B顺序添加;
在pH值>4.8环境中,按先粘胶液B后粘胶液A顺序添加;
1.2加样量:
粘胶液A、粘胶液B的加入量分别为2~8%v/v,即1000L待处理液加入20~80L粘胶液A、20~80L粘胶液B。
2.观察
当加入第一组份组份时,稍搅拌可见溶液明显变浑,或可见小的絮状物,当加入第二种组份时,3~5分钟内即可见明显的絮状物,上清液透明,无乳光。
3.分离
3.1将溶液置入澄清罐中静置4~6h,虹吸上清液,用纱布粗滤去除大的絮状物,然精滤,即得澄清液体。
3.2用管式离心机,无需静置,即可进行液固分离。处理量为每小时0.5~1.5吨,然后精密过滤即得澄清液体。
试验例
1、取中药提取液,溶液比重≤1.100,然后分别采用实施例1~9中的天然澄清剂进行澄清,澄清步骤采用实施例10所述,中药提取液中鞣质、蛋白质去除率结果如下:
上表显示,本发明的澄清剂对中药提取液的澄清效果优秀,能够较彻底的清除鞣质、杂蛋白等杂质,达到较高的透光率,并且可以确定的是,天然澄清剂9效果为最理想,澄清度达到98%(透光率)以上,为非常澄清级别,一步、二步清除率也达到标准。
2、同样取中药提取液,溶液比重≤1.100,分成两份采用天然澄清剂9进行澄清,澄清步骤采用实施例10所述,一份在70~80℃加入澄清剂后保温2小时,另一份加样温度为50~65℃保温2小时,效果差异见下表。
天然澄清剂9 | 澄清耗时 | 一步清除率 | 二步清除率 | 透光率T(%) |
70~80℃加样 | 6h | 75% | 94% | 99.10 |
50~65℃加样 | 6h | 72% | 90% | 98.30 |
上表显示的结果表明,在加热至80℃左右情况下,澄清效果会更好。
Claims (7)
1.一种天然澄清剂的使用方法,其特征在于:
所述天然澄清剂包括A组份和B组份,A组份包含15~65%wt海藻酸丙二醇酯、5~50%wt海藻酸钠、20~45%wt膨润土,B组份包含25~85%wt壳聚糖、15~75%wt卡拉胶;
所述的天然澄清剂的使用方法如下:
1)将A组份用水稀释并使其充分溶胀,过滤得到浓度0.5~1%w/v的粘胶液A;
将B组份用0.6~1.3%v/v醋酸稀释并使其充分溶胀,过滤得到浓度0.5~1%w/v的粘胶液B;
2)测定待澄清液体的pH值,当pH值≤4.8时,先加入粘胶液A,稍搅拌见溶液明显变浑或小的絮状物后,再加入粘胶液B,使待澄清液体内有明显的絮状物,上清液透明,无乳光;
当pH值>4.8时,先加入粘胶液B,稍搅拌见溶液明显变浑或小的絮状物后,再加入粘胶液A,使待澄清液体内有明显的絮状物,上清液透明,无乳光;
3)将包含有絮状物的待澄清液体静置分离或离心分离,过滤得到澄清液体。
2.根据权利要求1所述的天然澄清剂的使用方法,其特征在于:所述天然澄清剂A组份包含32~55%wt海藻酸丙二醇酯、16~38%wt海藻酸钠、28~35%wt膨润土。
3.根据权利要求1或2所述的天然澄清剂的使用方法,其特征在于:所述天然澄清剂B组份包含36~75%wt壳聚糖、25~64%wt卡拉胶。
4.根据权利要求1所述的天然澄清剂的使用方法,其特征在于:所述天然澄清剂A组份包含37%wt海藻酸丙二醇酯、35%wt海藻酸钠、28%wt膨润土。
5.根据权利要求1或4所述的天然澄清剂的使用方法,其特征在于:所述天然澄清剂B组份包含65%wt壳聚糖、35%wt卡拉胶。
6.根据权利要求1所述的天然澄清剂的使用方法,其特征在于:待澄清液体中A组份的添加量为200~800ppm,B组份的添加量也为200~800ppm。
7.根据权利要求1所述的天然澄清剂的使用方法,其特征在于:所述步骤1)为,将A组份用水稀释并使其充分溶胀,过滤得到浓度1%w/v的粘胶液A;
将B组份用1%v/v醋酸稀释并使其充分溶胀,过滤得到浓度1%w/v的粘胶液B。
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