CN106255877B - 使用线虫的嗅觉的癌检测法 - Google Patents

使用线虫的嗅觉的癌检测法 Download PDF

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Publication number
CN106255877B
CN106255877B CN201480075291.9A CN201480075291A CN106255877B CN 106255877 B CN106255877 B CN 106255877B CN 201480075291 A CN201480075291 A CN 201480075291A CN 106255877 B CN106255877 B CN 106255877B
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cancer
nematode
nematodes
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diacetyl
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CN106255877A (zh
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广津崇亮
园田英人
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Guangjin Bioscience Co Ltd
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Kyushu University NUC
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
    • G01N2333/43534—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Urology & Nephrology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Food Science & Technology (AREA)
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  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN201480075291.9A 2013-12-10 2014-12-10 使用线虫的嗅觉的癌检测法 Active CN106255877B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2013-255145 2013-12-10
JP2013255145 2013-12-10
US201461982341P 2014-04-22 2014-04-22
US61/982,341 2014-04-22
PCT/JP2014/083320 WO2015088039A1 (ja) 2013-12-10 2014-12-10 線虫の嗅覚を用いた癌検出法

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CN106255877A CN106255877A (zh) 2016-12-21
CN106255877B true CN106255877B (zh) 2018-06-05

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EP (1) EP3081935B2 (enExample)
JP (6) JP6336481B2 (enExample)
KR (1) KR102247737B1 (enExample)
CN (1) CN106255877B (enExample)
DK (1) DK3081935T4 (enExample)
ES (1) ES2707977T5 (enExample)
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HR (1) HRP20190338T4 (enExample)
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PT (1) PT3081935T (enExample)
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Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6522778B2 (ja) * 2015-11-10 2019-05-29 株式会社日立製作所 癌検査システム及び癌検査評価方法
US11443851B2 (en) * 2015-11-30 2022-09-13 Hirotsu Bio Science Inc. Cancer test system and method for assessing cancer test
JP6556063B2 (ja) * 2016-01-25 2019-08-07 株式会社日立製作所 保険システム、情報提供サーバ及び保険リスク算出方法
WO2017149626A1 (ja) * 2016-02-29 2017-09-08 株式会社日立製作所 がん解析システム及びがん解析方法
KR101907151B1 (ko) * 2016-05-18 2018-10-12 이동선 디아세틸을 포함하는, 암 줄기세포 성장 억제용 조성물
WO2017213246A1 (ja) 2016-06-10 2017-12-14 株式会社日立製作所 尿中代謝物による疾病診断法
JP6747908B2 (ja) * 2016-08-09 2020-08-26 株式会社Ｈｉｒｏｔｓｕバイオサイエンス バッファ吸取装置及びがん解析システム
WO2018047959A1 (ja) * 2016-09-12 2018-03-15 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 線虫の嗅覚に基づく匂い物質に対する走性行動の評価方法、並びに該評価方法に用いるシャーレおよび行動評価系
JP6164622B1 (ja) * 2016-09-12 2017-07-19 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 線虫の嗅覚に基づく匂い物質に対する走性行動の評価方法、および該評価方法に用いるシャーレ
JP7076199B2 (ja) * 2016-12-01 2022-05-27 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 匂い物質の検出方法
JP7045680B2 (ja) * 2017-02-16 2022-04-01 国立大学法人東北大学 線虫を用いた物質の生理活性評価法
JP6788921B2 (ja) * 2017-03-31 2020-11-25 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 線虫の嗅覚の感度を向上させる化合物
WO2018181869A1 (ja) * 2017-03-31 2018-10-04 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 線虫変異体を含むがんの診断薬および該変異体を用いた走性行動評価方法
CN117347612A (zh) * 2017-03-31 2024-01-05 广津生物科学株式会社 癌患者的治疗效果的预测和/或复发监测
JP7100323B2 (ja) * 2017-07-11 2022-07-13 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 組織検体を用いたがんの検出方法
WO2019039415A1 (ja) 2017-08-21 2019-02-28 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 腎臓がんの検出方法
IT201700119113A1 (it) * 2017-10-20 2019-04-20 Crestoptics S P A Apparato e metodo per il rilevamento automatizzato di sostanze odoranti in soluzione tramite impiego di nematodi Chaenorabditis Elegans
WO2019081551A1 (en) 2017-10-26 2019-05-02 Merck Patent Gmbh METHOD FOR REALIZING A CHEMOTAXIS ASSAY ON A POROUS WET SURFACE
WO2020036187A1 (ja) 2018-08-14 2020-02-20 株式会社Ｈｉｒｏｔｓｕバイオサイエンス ペットにおけるがんの検査方法
JP7442785B2 (ja) * 2019-12-06 2024-03-05 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 走性解析方法、がん評価方法、走性解析システム及びプログラム
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US12377711B2 (en) 2020-08-20 2025-08-05 Denso International America, Inc. Vehicle feature control systems and methods based on smoking
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US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
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US12251991B2 (en) 2020-08-20 2025-03-18 Denso International America, Inc. Humidity control for olfaction sensors
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KR20240087731A (ko) * 2021-08-24 2024-06-19 온코텍트, 인코포레이티드 반려 동물의 암 스크리닝
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CN117678573A (zh) * 2023-11-01 2024-03-12 壮子恒 使用线虫的嗅觉的孤独谱系障碍检测方法
JP7734807B1 (ja) 2024-08-09 2025-09-05 住友化学株式会社 判定方法、判定装置及びコンピュータプログラム
JP2026031369A (ja) * 2024-08-09 2026-02-24 住友化学株式会社 がんの検査剤
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CN121040468A (zh) * 2025-11-03 2025-12-02 云南大学 一种吡嗪类化合物在制备植物寄生线虫引诱剂上的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010164505A (ja) * 2009-01-19 2010-07-29 Japan Science & Technology Agency ドーパミンシグナル伝達阻害剤のスクリーニング方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11215934A (ja) * 1998-01-30 1999-08-10 Sanyo Electric Co Ltd 探索物質に基いて特異行動を示す生物体、これを用いた物質探索方法及び物質処理方法
US20100248268A1 (en) 2001-03-27 2010-09-30 Woods Daniel F Methods to utilize invertebrate chemosensory proteins for industrial and commercial uses
WO2004033654A2 (en) * 2002-10-09 2004-04-22 Buck Institute Automated method for high throughput screening of nematodes
IT201700119113A1 (it) 2017-10-20 2019-04-20 Crestoptics S P A Apparato e metodo per il rilevamento automatizzato di sostanze odoranti in soluzione tramite impiego di nematodi Chaenorabditis Elegans

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010164505A (ja) * 2009-01-19 2010-07-29 Japan Science & Technology Agency ドーパミンシグナル伝達阻害剤のスクリーニング方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
《Analysis of the molecular mechanism of signal transduction and identification of novel molecules in neural circuit-dependent odor adaptation in C.elegans》;HIROTSU Takaaki;《科学研究费补助金研究成果报告书》;20100519;3（2）和4（2） *
《Divergent seven transmembrane receptors are candidate chemosensory receptors in C.elegans》;Emily R.Troemel等;《cell》;19951020;第83卷;全文 *
《Odorant-selective genes and neurons mediate olfaction in C. elegans》;Cornelia I.Bargmann等;《cell》;19930313;第74卷;全文 *

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US20170016906A1 (en) 2017-01-19
JP7111791B2 (ja) 2022-08-02
PT3081935T (pt) 2019-02-14
JP7770483B2 (ja) 2025-11-14
ES2707977T3 (es) 2019-04-08
ES2707977T5 (es) 2024-04-18
CN106255877A (zh) 2016-12-21
JP2021048856A (ja) 2021-04-01
HRP20190338T4 (hr) 2023-12-22
US12493040B2 (en) 2025-12-09
JP6629358B2 (ja) 2020-01-15
EP3081935B2 (en) 2023-11-15
EP3081935A4 (en) 2017-08-16
JP7520921B2 (ja) 2024-07-23
EP3081935A1 (en) 2016-10-19
JP6802341B6 (ja) 2021-01-20
JP2018061515A (ja) 2018-04-19
DK3081935T3 (en) 2019-01-28
MY172330A (en) 2019-11-21
US20210356470A1 (en) 2021-11-18
US11719698B2 (en) 2023-08-08
FI3081935T4 (fi) 2023-12-28
KR20160095135A (ko) 2016-08-10
SG11201604743QA (en) 2016-07-28
EP3081935B1 (en) 2018-11-21
DK3081935T4 (da) 2023-12-04
JP2024138430A (ja) 2024-10-08
WO2015088039A1 (ja) 2015-06-18
US20230204590A1 (en) 2023-06-29
JPWO2015088039A1 (ja) 2017-03-16
SG10201900889WA (en) 2019-03-28
JP2022140518A (ja) 2022-09-26
JP2020031649A (ja) 2020-03-05
HRP20190338T1 (hr) 2019-05-03
JP6336481B2 (ja) 2018-06-06
JP6802341B2 (ja) 2020-12-16
KR102247737B1 (ko) 2021-05-04

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