CN106232122A - Irak抑制剂和其用途 - Google Patents

Irak抑制剂和其用途 Download PDF

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Publication number
CN106232122A
CN106232122A CN201480061479.8A CN201480061479A CN106232122A CN 106232122 A CN106232122 A CN 106232122A CN 201480061479 A CN201480061479 A CN 201480061479A CN 106232122 A CN106232122 A CN 106232122A
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Prior art keywords
disease
compound
cancer
irak
compounds
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Pending
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CN201480061479.8A
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Chinese (zh)
Inventor
多纳·L·罗曼罗
克雷格·E·马斯
肖奈希·罗宾逊
杰里米·罗伯特·格林伍德
杰拉尔丁·哈里曼
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Nimbus Iris Inc
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Nimbus Iris Inc
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Publication of CN106232122A publication Critical patent/CN106232122A/zh
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CN201480061479.8A 2013-09-27 2014-09-25 Irak抑制剂和其用途 Pending CN106232122A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361883497P 2013-09-27 2013-09-27
US61/883,497 2013-09-27
PCT/US2014/057444 WO2015048281A1 (en) 2013-09-27 2014-09-25 Irak inhibitors and uses thereof

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CN106232122A true CN106232122A (zh) 2016-12-14

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US (2) US9518065B2 (https=)
EP (1) EP3049086A4 (https=)
JP (1) JP2016531870A (https=)
KR (1) KR20160092991A (https=)
CN (1) CN106232122A (https=)
BR (1) BR112016006319A2 (https=)
CA (1) CA2925211A1 (https=)
MX (1) MX2016003843A (https=)
RU (1) RU2016110852A (https=)
TW (1) TW201522349A (https=)
WO (1) WO2015048281A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020001449A1 (zh) * 2018-06-25 2020-01-02 南京明德新药研发有限公司 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物
CN111655261A (zh) * 2017-12-19 2020-09-11 X4 制药有限公司 非环状cxcr4抑制剂和其用途
CN112236429A (zh) * 2018-04-05 2021-01-15 默克专利有限公司 用作ii型irak抑制剂的杂芳基化合物及其用途
WO2021147968A1 (zh) * 2020-01-21 2021-07-29 正大天晴药业集团股份有限公司 一种irak4抑制剂的结晶及其制备方法
WO2024179393A1 (zh) * 2023-02-27 2024-09-06 科辉智药(深圳)新药研究中心有限公司 亚砜酰亚胺化合物及其作为lrrk2蛋白激酶抑制剂的应用

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