CN106187927A - 一种Lesinurad中间体的制备方法 - Google Patents
一种Lesinurad中间体的制备方法 Download PDFInfo
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- CN106187927A CN106187927A CN201610592925.9A CN201610592925A CN106187927A CN 106187927 A CN106187927 A CN 106187927A CN 201610592925 A CN201610592925 A CN 201610592925A CN 106187927 A CN106187927 A CN 106187927A
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- triazole
- methyl
- sulfur
- methyl acetate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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Priority Applications (1)
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CN201610592925.9A CN106187927B (zh) | 2016-07-26 | 2016-07-26 | 一种Lesinurad中间体的制备方法 |
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CN201610592925.9A CN106187927B (zh) | 2016-07-26 | 2016-07-26 | 一种Lesinurad中间体的制备方法 |
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CN106187927A true CN106187927A (zh) | 2016-12-07 |
CN106187927B CN106187927B (zh) | 2020-02-04 |
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CN201610592925.9A Active CN106187927B (zh) | 2016-07-26 | 2016-07-26 | 一种Lesinurad中间体的制备方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106866560A (zh) * | 2017-03-30 | 2017-06-20 | 浙江美诺华药物化学有限公司 | 一种Lesinurad的合成方法 |
CN112110866A (zh) * | 2019-06-20 | 2020-12-22 | 北京万全德众医药生物技术有限公司 | 一种雷西纳德的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104736522A (zh) * | 2012-07-03 | 2015-06-24 | 阿迪亚生命科学公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的制备 |
CN104987311A (zh) * | 2015-06-30 | 2015-10-21 | 安徽万邦医药科技有限公司 | 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯 |
CN105017168A (zh) * | 2015-07-01 | 2015-11-04 | 安徽万邦医药科技有限公司 | 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法 |
CN105263913A (zh) * | 2013-06-14 | 2016-01-20 | 广东东阳光药业有限公司 | 硫代1,2,4-三唑衍生物及其制备方法 |
CN105399694A (zh) * | 2015-12-11 | 2016-03-16 | 浙江京新药业股份有限公司 | 药物Lesinurad轴手性对映体 |
-
2016
- 2016-07-26 CN CN201610592925.9A patent/CN106187927B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104736522A (zh) * | 2012-07-03 | 2015-06-24 | 阿迪亚生命科学公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的制备 |
CN105263913A (zh) * | 2013-06-14 | 2016-01-20 | 广东东阳光药业有限公司 | 硫代1,2,4-三唑衍生物及其制备方法 |
CN104987311A (zh) * | 2015-06-30 | 2015-10-21 | 安徽万邦医药科技有限公司 | 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯 |
CN105017168A (zh) * | 2015-07-01 | 2015-11-04 | 安徽万邦医药科技有限公司 | 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法 |
CN105399694A (zh) * | 2015-12-11 | 2016-03-16 | 浙江京新药业股份有限公司 | 药物Lesinurad轴手性对映体 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106866560A (zh) * | 2017-03-30 | 2017-06-20 | 浙江美诺华药物化学有限公司 | 一种Lesinurad的合成方法 |
CN106866560B (zh) * | 2017-03-30 | 2023-05-30 | 浙江美诺华药物化学有限公司 | 一种Lesinurad的合成方法 |
CN112110866A (zh) * | 2019-06-20 | 2020-12-22 | 北京万全德众医药生物技术有限公司 | 一种雷西纳德的制备方法 |
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CN106187927B (zh) | 2020-02-04 |
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Address after: 252022 north head of Lushan Road, Liaocheng Development Zone, Shandong Province Patentee after: Shandong Chuan Cheng Medicine Co.,Ltd. Address before: 252022 north of the Mount Lu, Liaocheng economic and Technological Development Zone, Shandong Patentee before: SHANDONG CHUANCHENG PHARMACEUTICAL Co.,Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of lesinurad intermediate Effective date of registration: 20211221 Granted publication date: 20200204 Pledgee: Liaocheng high tech Zone Luxi small loan Co.,Ltd. Pledgor: Shandong Chuan Cheng Medicine Co.,Ltd. Registration number: Y2021980015625 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220330 Granted publication date: 20200204 Pledgee: Liaocheng high tech Zone Luxi small loan Co.,Ltd. Pledgor: Shandong Chuan Cheng Medicine Co.,Ltd. Registration number: Y2021980015625 |