CN106177494A - 一种铁皮石斛抽提物含片及其制备方法 - Google Patents
一种铁皮石斛抽提物含片及其制备方法 Download PDFInfo
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- CN106177494A CN106177494A CN201610652181.5A CN201610652181A CN106177494A CN 106177494 A CN106177494 A CN 106177494A CN 201610652181 A CN201610652181 A CN 201610652181A CN 106177494 A CN106177494 A CN 106177494A
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- herba dendrobii
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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Abstract
一种铁皮石斛抽提物含片及其制备方法，涉及铁皮石斛。所述铁皮石斛抽提物含片按质量百分比各原料的含量为:铁皮石斛抽提物20％～50％、葛根粉10％～40％、甘露醇15％～30％、低聚果糖5％～20％、低聚葡萄糖5％～30％，总含量为100％。制备：1)将铁皮石斛新鲜枝条用水清洗，去杂质，粉碎后加水提取，提取液过滤后，再加水重复抽提一次,合并抽提液，再真空浓缩，浓缩液喷雾干燥后过筛，得铁皮石斛抽提物干粉；2)将葛根粉、甘露醇、低聚果糖、低聚葡萄糖和步骤1)得到的铁皮石斛抽提物干粉混合，加入质量百分浓度为70％的乙醇作为润湿剂，搅拌后将混合料制粒，干燥后加入硬脂酸镁，压片即得铁皮石斛抽提物含片。
Description
技术领域
本发明涉及铁皮石斛，具体是涉及一种铁皮石斛抽提物含片及其制备方法。
背景技术
铁皮石斛是我国珍贵的中药材之一，被尊称为“中华九大仙草”之首(铁皮石斛、天山雪莲、千年人参、百二十年首乌、花甲之茯苓、苁蓉、深山灵芝、海底珍珠、冬虫夏草)，素有“药中黄金”之美称。《本草纲目拾遗》记载铁皮石斛具有生津养胃、滋阴清热、润肺益肾、明目强腰的功效。现代科学研究表明，铁皮石斛含有石斛多糖、石斛碱、石斛酚、石斛胺，氨基酸，还有特殊的菲类、联苄类等成分。铁皮石斛中石斛活性多糖含量在22％以上。药理研究证明石斛活性多糖具有抗肿瘤、消炎、降血压、降血糖、抑制脂质过氧化、抗衰老、加快体质恢复、提高人体白细胞数量、癌症辅助治疗、提高人体免疫力等功效。石斛碱具有明显的抗肿瘤活性，可抑制肿瘤细胞生长，通过提高人体免疫力来降低放化疗对人体的毒副作用。铁皮石斛中含有的两种菲类化合物鼓槌菲(chrysotoxene)和毛兰素(erianin)，有抵抗人体肺癌细胞、卵巢癌细胞的作用，还有抵抗前髓细胞白血病的功效。铁皮石斛中含有18种氨基酸，具有抗氧化、抗衰老、降血糖、保肝润肺、软化血管、养胃护胃等保健功效。铁皮石斛中含有多种微量元素，能够补养人体所需，调节新陈代谢，有利于人体健康长寿。热水抽提结合喷雾干燥工艺可以去除铁皮石斛中影响口感和有效成分吸收的木质素，并能最大限度地保留铁皮石斛中的石斛多糖、石斛碱、石斛酚、石斛胺，氨基酸等活性成分。
中国专利CN105169118A公开一种铁皮石斛复方保健含片及其制备方法，由主料和辅料组成，所述主料按重量比，包括以下成份：铁皮石斛破壁粉20-30份、灵芝破壁粉10-15份、田七破壁粉提取物10-15份、桑叶破壁粉提取物6-12份、山药粉5-10份、当归粉1-5份、淫羊藿粉1-5份、山楂粉1-5份、藏红花粉2-6份、茯苓粉1-3份、地黄粉2-5份、何首乌粉2-3份、决明子粉1-3份、夏枯草粉2-5份、荷叶粉2-5份、麦芽粉1-3份、葛根粉5-8份、苦瓜5-10份；辅料包括：糊精35-60份、木糖醇20-30份、阿斯巴甜0.5-1.5份、柠檬酸5-8份；体积浓度为65-95％的乙醇溶液0.4-0.6份；硬脂酸镁1-2份。
中国专利CN102716367A公开一种复方铁皮石斛含片及其制备方法。包括按重量比例混合的复方铁皮石斛提取物浸膏、甘露醇、糊精以及硬脂酸镁；所述复方铁皮石斛提取物浸膏含有按重量比例确定的铁皮石斛、西洋参、枸杞子、芦根、黄秋葵、桑椹、黄芪的提取物。上述含片的制备方法，按下述步骤制作：(1)按原料配比取料；(2)将西洋参回流提取处理获得浸膏A；(3)将提取后的西洋参药渣与其余原料混合煎煮提取获得浸膏B；(4)将浸膏A与浸膏B混合后浓缩，得复方铁皮石斛提取物浸膏；(5)制粒；(6)压片。
中国专利CN105288215A公开一种高活性铁皮石斛冻干粉口含片及其制备工艺，所述口含片由以下原料制成：铁皮石斛冻干粉、木醇糖、枸杞提取物、甘露醇、异麦芽糖醇、羧甲基淀粉钠、硬脂酸镁。
中国专利CN105497568A公开一种具有养护咽喉功能的铁皮石斛含片，包括铁皮石斛、西洋参、麦冬、桔梗、甘草、糊精、甘露醇、安赛蜜、葡萄糖、淀粉、二氧化硅、硬脂酸镁，铁皮石斛占物料总质量的20～30％，西洋参占物料总质量的10～30％，麦冬占物料总质量的10～30％，桔梗占物料总质量的10～30％，甘草占物料总质量的5～10％，糊精占物料总质量的5～10％，甘露醇占物料总质量的0.05～0.1％，安赛蜜占物料总质量的0.01～0.03％，葡萄糖占物料总质量的1～5％，淀粉占物料总质量的3～5％，二氧化硅占物料总质量的1～5％，硬脂酸镁占物料总质量的1％。
发明内容
本发明的目的在于提供一种铁皮石斛抽提物含片及其制备方法。
所述铁皮石斛抽提物含片的原料包括铁皮石斛抽提物、葛根粉、甘露醇、低聚果糖、低聚葡萄糖，按质量百分比各原料的含量为:铁皮石斛抽提物20％～50％、葛根粉10％～40％、甘露醇15％～30％、低聚果糖5％～20％、低聚葡萄糖5％～30％，总含量为100％。
所述铁皮石斛抽提物含片的制备方法，包括以下步骤：
1)将铁皮石斛新鲜枝条用水清洗，去杂质，粉碎后加水提取，提取液过滤后，再加水重复抽提一次,合并抽提液，再真空浓缩，浓缩液喷雾干燥后过筛，得铁皮石斛抽提物干粉；
2)将葛根粉、甘露醇、低聚果糖、低聚葡萄糖和步骤1)得到的铁皮石斛抽提物干粉混合，加入质量百分浓度为70％的乙醇作为润湿剂，搅拌后将混合料制粒，干燥后加入硬脂酸镁，压片，即得铁皮石斛抽提物含片。
在步骤1)中，所述粉碎后加水提取的加水量与粉碎后的铁皮石斛的质量比可为30︰1；所述提取的温度可为60～80℃，提取的时间可为1h；所述再加水重复抽提一次的加水量与铁皮石斛的质量比可为20︰1；所述真空浓缩可将抽提液转入旋转蒸发器，于60℃抽真空浓缩；所述过筛可过120目筛。
在步骤2)中，所述混合可将葛根粉、甘露醇、低聚果糖、低聚葡萄糖和步骤1)得到的铁皮石斛抽提物干粉投入多维混合机混合30min；所述制粒可将混合料投入摇摆式颗粒机制粒；所述干燥的条件可为：置于热风循环干燥箱中在55～60℃温控条件下干燥；所述硬脂酸镁的加入量按质量百分比可为混合料的0.5％。
石斛碱具有明显的抗肿瘤活性，可抑制肿瘤细胞生长，通过提高人体免疫力来降低放化疗对人体的毒副作用。铁皮石斛中含有的两种菲类化合物鼓槌菲和毛兰素，有抵抗人体肺癌细胞、卵巢癌细胞的作用，还有抵抗前髓细胞白血病的功效。铁皮石斛中含有18种氨基酸，具有抗氧化、抗衰老、降血糖、保肝润肺、软化血管、养胃护胃等保健功效。铁皮石斛中含有多种微量元素，能够补养人体所需，调节新陈代谢，有利于人体健康长寿。热水抽提结合喷雾干燥工艺可以去除铁皮石斛中影响口感和有效成分吸收的木质素，并能最大限度地保留铁皮石斛中的石斛多糖、石斛碱、石斛酚、石斛胺，氨基酸等活性成分。葛根粉在《本草纲目》已有记载，具有清热降火、滋阴补阳、生津止渴、开胃进食之功效，对治疗和预防胸膈烦热、中风头痛、高血压、冠心病、降血脂、抗癌、消癌肿、减肥胖、抗衰老等均有特殊功效。选择其它辅料时，本发明依照中医阴阳平衡、相辅相成之原则进行。作为辅料，甘露醇、低聚果糖和低聚葡萄糖不仅成片特性好，还兼具口感甜爽和益生保健之功效。
本发明在我国传统医学的实践验证基础之上，结合最新现代科学研究成果，提供一种铁皮石斛抽提物含片保健品，该保健品的原料包括铁皮石斛抽提物、葛根粉、甘露醇、低聚果糖、低聚葡萄糖，具有生津养胃、滋阴清热、润肺益肾、明目强腰的功效，经常服用，可以提高免疫力，并有利于控制高血脂和高血压。
具体实施方式
以下实施例将对本发明作进一步的说明。
实施例1
依据本发明上述制备方法准备铁皮石斛抽提物干粉。
组方：铁皮石斛抽提物干粉200份、葛根粉300份、甘露醇200份、低聚果糖100份、低聚葡萄糖200份。按以上配比取原料,投入多维混合机充分混合30min,然后加入70％酒精作为润湿剂,搅拌之后将混合料投入摇摆式颗粒机制粒；将湿颗粒置于热风循环干燥箱中在60℃温控条件下干燥；整粒均匀后加入总干重的0.5％硬脂酸镁混合,用压片机进行压片,制成800mg/粒的铁皮石斛口含片，装袋或者装瓶。用法与用量:口服,一日3次,一次1粒。
实施例2
依据本发明上述制备方法准备铁皮石斛抽提物干粉。
组方：铁皮石斛抽提物干粉400份、葛根粉240份、甘露醇260份、低聚果糖50份、低聚葡萄糖50份。按以上配比取原料,投入多维混合机充分混合30min,然后加入70％酒精作为润湿剂,搅拌之后将混合料投入摇摆式颗粒机制粒；将湿颗粒置于热风循环干燥箱中在55℃温控条件下干燥；整粒均匀后加入总干重的0.5％硬脂酸镁混合,用压片机进行压片,制成750mg/粒的铁皮石斛口含片，装袋或者装瓶。用法与用量:口服,一日2～3次,一次1粒。
实施例3
依据本发明上述制备方法准备铁皮石斛抽提物干粉。
组方：铁皮石斛抽提物干粉450份、葛根粉220份、甘露醇230份、低聚果糖50份、低聚葡萄糖50份。按以上配比取原料,投入多维混合机充分混合30min,然后加入70％酒精作为润湿剂,搅拌之后将混合料投入摇摆式颗粒机制粒；将湿颗粒置于热风循环干燥箱中在60℃温控条件下干燥；整粒均匀后加入总干重的0.5％硬脂酸镁混合,用压片机进行压片,制成900mg/粒的铁皮石斛口含片，装袋或者装瓶。用法与用量:口服,一日2次,一次1粒。
实施例4
与实施例1类似，其区别在于组方为:铁皮石斛抽提物干粉500份、葛根粉400份、甘露醇300份、低聚果糖200份、低聚葡萄糖300份。
实施例5
与实施例1类似，其区别在于组方为:铁皮石斛抽提物干粉300份、葛根粉100份、甘露醇150份、低聚果糖150份、低聚葡萄糖100份。
Claims (10)
1.一种铁皮石斛抽提物含片，其特征在于其原料包括铁皮石斛抽提物、葛根粉、甘露醇、低聚果糖、低聚葡萄糖，按质量百分比各原料的含量为:铁皮石斛抽提物20％～50％、葛根粉10％～40％、甘露醇15％～30％、低聚果糖5％～20％、低聚葡萄糖5％～30％，总含量为100％。
2.如权利要求1所述铁皮石斛抽提物含片的制备方法，其特征在于包括以下步骤：
1)将铁皮石斛新鲜枝条用水清洗，去杂质，粉碎后加水提取，提取液过滤后，再加水重复抽提一次,合并抽提液，再真空浓缩，浓缩液喷雾干燥后过筛，得铁皮石斛抽提物干粉；
2)将葛根粉、甘露醇、低聚果糖、低聚葡萄糖和步骤1)得到的铁皮石斛抽提物干粉混合，加入质量百分浓度为70％的乙醇作为润湿剂，搅拌后将混合料制粒，干燥后加入硬脂酸镁，压片，即得铁皮石斛抽提物含片。
3.如权利要求2所述铁皮石斛抽提物含片的制备方法，其特征在于在步骤1)中，所述粉碎后加水提取的加水量与粉碎后的铁皮石斛的质量比为30︰1。
4.如权利要求2所述铁皮石斛抽提物含片的制备方法，其特征在于在步骤1)中，所述提取的温度为60～80℃，提取的时间为1h。
5.如权利要求2所述铁皮石斛抽提物含片的制备方法，其特征在于在步骤1)中，所述再加水重复抽提一次的加水量与铁皮石斛的质量比为20︰1。
6.如权利要求2所述铁皮石斛抽提物含片的制备方法，其特征在于在步骤1)中，所述真空浓缩是将抽提液转入旋转蒸发器，于60℃抽真空浓缩。
7.如权利要求2所述铁皮石斛抽提物含片的制备方法，其特征在于在步骤1)中，所述过筛是过120目筛。
8.如权利要求2所述铁皮石斛抽提物含片的制备方法，其特征在于在步骤2)中，所述混合是将葛根粉、甘露醇、低聚果糖、低聚葡萄糖和步骤1)得到的铁皮石斛抽提物干粉投入多维混合机混合30min。
9.如权利要求2所述铁皮石斛抽提物含片的制备方法，其特征在于在步骤2)中，所述制粒是将混合料投入摇摆式颗粒机制粒；所述干燥的条件可为：置于热风循环干燥箱中在55～60℃温控条件下干燥。
10.如权利要求2所述铁皮石斛抽提物含片的制备方法，其特征在于在步骤2)中，所述硬脂酸镁的加入量按质量百分比为混合料的0.5％。
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107549408A (zh) * | 2017-10-23 | 2018-01-09 | 广州刘长标中药研发有限公司 | 一种降压茶及制备方法 |
| CN109380725A (zh) * | 2018-12-13 | 2019-02-26 | 浙江兰溪锦荣生物科技股份有限公司 | 一种含有石斛可溶性膳食纤维的石斛咀嚼片及其制备方法 |
| CN111513330A (zh) * | 2020-05-22 | 2020-08-11 | 普洱市民族传统医药研究所 | 增强免疫力的铁皮石斛葛根三七颗粒制备工艺 |
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