CN111513330A - 增强免疫力的铁皮石斛葛根三七颗粒制备工艺 - Google Patents
增强免疫力的铁皮石斛葛根三七颗粒制备工艺 Download PDFInfo
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Abstract
本发明涉及保健食品制备方法，特别是具有增强免疫力的铁皮石斛葛根三七颗粒制备工艺。提供一种改善人体免疫力食品。增强免疫力的铁皮石斛葛根三七颗粒制备工艺，具体采用如下步骤进行制备：①提取、过滤；②浓缩、干燥；③粉碎：铁皮石斛和葛根药材经提取后为干膏，进行破碎粉碎，后过100目筛；④混合；⑤制粒：加75%乙醇润湿，过14目刚筛制粒，60℃干燥。⑥整粒：将颗粒过14目筛整粒。⑦包装；⑧入库。工艺铁皮石斛和葛根都是通过水提煮后加入水提物，这比以前使铁皮石斛和葛根有效成份更易吸收，更有安全性和符合医学标准。
Description
技术领域
本发明涉及保健食品制备方法，特别是具有增强免疫力的铁皮石斛葛根三七颗粒制备工艺。
背景技术
随着生活水平的提高及社会竞争压力，饮食不合理。休息不足，特别是睡眠不足、起居无规律、作息不正常已经成为常见现象。过度紧张，压力太大。特别是IT白领人士，身体运动不足，体力透支。长久的不良情绪影响等，使得处于亚健康的人群日益增加，抵抗力下降，增加了各种病菌的入侵，影响日常工作。
随着生活水平的提高和生活节奏的改变，被称为“富贵病”的“三高症”（即高血压、高血糖和高血脂），已如“旧时王谢堂前燕，飞入寻常百姓家”,特别是50岁以上中老年人健康的常见病，全世界每年死于心脑血管疾病的人数高达1500万人，居各种死因首位。心脑血管疾病已成为人类死亡病因最高的“头号杀手”，也是人们健康的“无声凶煞”，心脑血管疾病具有“发病率高、致残率高、死亡率高、复发率高,并发症多”形成“四高一多”的特点，目前，我国心脑血管疾病患者已经超过2.7亿人。
免疫系统是人体自身的防御机制，是人体识别和消灭外来侵入的任何异物（病毒、细菌等），处理衰老、损伤、死亡、变性的自身细胞以及识别和处理体内突变细胞和病毒感染细胞的能力。因此提高机体免疫力对于预防和控制疾病、抑制肿瘤的形成有非常重要的作用。现代医学认为，增强免疫力是将亚健康状态转变为健康状态。据世界卫生组织调查，在全世界范围内有70%以上的人群处于亚健康状态。
传统药物在机体免疫系统调节方面的前景广阔，一方面，传统药物可以增强机体细胞免疫及体液免疫功能，促进淋巴细胞、单核巨噬细胞以及造血干细胞的生理功能；另一方面，传统药物也具有免疫抑制功能，能减少炎性因子的释放，抑制或消除抗体的产生，抑制T细胞的增殖等。近几年，研究发现传统药物中的多糖、皂苷、黄酮等成分具有很好的免疫调节、抗肿瘤作用，在一定剂量范围内能够调节机体免疫功能，使紊乱的机体免疫状态恢复正常。
发明内容
本发明提供一种能够有效提高人体免疫，采用中医药材配方更加合理，有利于人体吸收食用的铁皮石斛葛根三七颗粒制备工艺。
本发明解决其技术问题所采用的技术方案是：增强免疫力的铁皮石斛葛根三七颗粒制备工艺，具体采用如下步骤进行制备：
①提取、过滤：分别按干重称取1460-1530份铁皮石斛和1400-1510份葛根药材混合在一起，加入8倍药材重量的水，煮提取2次，每次2小时，提取液200目筛过滤，将两次所得滤液合并到一起。
②浓缩、干燥：将滤液减压浓缩，真空度-0.06Mpa，温度70℃，浓缩至相对密度为1.20～1.25（50℃），干燥，温度70℃，真空度-0.07Mpa，干燥12小时，含水量＜6%，得到干膏；
③粉碎：铁皮石斛和葛根药材经提取后为干膏，进行破碎粉碎，后过100目筛；
④混合：将粉碎得到的干膏粉370-412份三七粉、98-118份冰糖粉、45-56份淀粉、47-55份糊精按重量份数配比混合均匀。
⑤制粒：加75%乙醇润湿，过14目刚筛制粒，60℃干燥。
⑥整粒：将颗粒过14目筛整粒。
⑦包装：按照产品规格要求进行包装，规格为100袋/包或30袋/盒、每袋1份。
⑧入库：将包装好的产品进行辐照灭菌，按企业标准检验合格后入库。
本发明具有以下有益效果：铁皮石斛中含有丰富的水溶性多糖成份，为一类免疫增强剂，对提高小鼠外周白细胞和促进淋巴细胞产生移动因子具有明显作用，能改善甲亢型小鼠的虚弱症状，具有生津、抑制肿瘤、抗衰老和扩张血管等作用。三七的主要活性成分为三七总皂甙，三七总皂甙在细胞免疫功能、体液免疫功能和NK细胞免疫功能等方面具有明显的增强作用，是一种有效的免疫增强剂。本品申报功能为增强免疫力，因此确定本产品的功效成分为粗多糖、总皂甙。剂型对功效成分的稳定性及保健食品效果和生产销售有较大的影响。片剂和颗粒剂等剂型的保健食品具有食用、携带方便的特点。
附图说明
图1为本发明的结构示意图。
图中虚线方框为10万级洁净区。
具体实施方式
下面结合附图和实施例对本发明进一步说明。
实施例1
如图1所示，增强免疫力的铁皮石斛葛根三七颗粒制备工艺，具体采用如下步骤进行制备：①提取、过滤：分别按干重称取1490份铁皮石斛和1510份葛根药材混合在一起，加入8倍药材重量的水，采用煎煮方式进行提取2次，每次2小时，提取液200目筛过滤，将两次所得滤液合并到一起。煎煮方式获得的营养成分更容易在冲泡过程中溶解被人体吸收。
②浓缩、干燥：将滤液减压浓缩，真空度-0.06Mpa，温度70℃，浓缩至相对密度为1.20～1.25（50℃），干燥，温度70℃，真空度-0.07Mpa，干燥12小时，含水量＜6%，得到干膏；
③粉碎：铁皮石斛和葛根药材经提取后为干膏，进行破碎粉碎，后过100目筛；
① 混合：将粉碎得到的干膏粉410份三七粉、98份冰糖粉、46份淀粉、48份糊精按重量份数配比混合均匀。
⑤制粒：加75%乙醇润湿，过14目刚筛制粒，60℃干燥。
⑥整粒：将颗粒过14目筛整粒。
⑦包装：按照产品规格要求进行包装，规格为100袋/包或30袋/盒、每袋1份。
⑧入库：将包装好的产品进行辐照灭菌，按企业标准检验合格后入库。
本发明一种具有增强人体免疫功能的石斛保健品，具有养阴，增强人体免疫能力的作用，适用于免疫力低下的亚健康人群。具有活血化瘀，具有良好的预防“三高症”的作用。具有提高人体荷尔蒙，增强人体的青春活力。
葛根含有丰富的葛根素、荀根素本糖甙、大豆异黄酮、大豆甙元、氨斟酸、微量元素、三萜类物质碱等对人体有益的重要生物活性物质，能调节人体机能，增强体质，提高机体抗病能力，抗衰延年，永葆青春活力。葛根其主要成分是淀粉，此外含有约12％的黄酮类化合物，包括大豆(黄豆)甙、大豆甙元、葛根素等10余种，所以本发明采用大孔吸附树脂法提取葛根素，把作用不大的淀粉去除。
实施例2
增强免疫力的铁皮石斛葛根三七颗粒制备工艺，具体采用如下步骤进行制备：①提取、过滤：分别按干重称取1500克铁皮石斛和1500克葛根药材混合在一起，加入8倍药材重量的水，煮提取2次，每次2小时，提取液200目筛过滤，将两次所得滤液合并到一起。
②浓缩、干燥：将滤液减压浓缩，真空度-0.06Mpa，温度70℃，浓缩至相对密度为1.20～1.25（50℃），干燥，温度70℃，真空度-0.07Mpa，干燥12小时，含水量＜6%，得到干膏；
③粉碎：铁皮石斛和葛根药材经提取后为干膏，进行破碎粉碎，后过100目筛；
① 混合：将粉碎得到的干膏粉加入400克三七粉、100克冰糖粉、50克淀粉、50克糊精按重量份数配比混合均匀。
⑤制粒：加75%乙醇润湿，过14目刚筛制粒，60℃干燥。
⑥整粒：将颗粒过14目筛整粒。
⑦包装：按照产品规格要求进行包装，规格为100袋/包或30袋/盒、每袋1克。
⑧入库：将包装好的产品进行辐照灭菌，按企业标准检验合格后入库。
本发明是保健品制剂，制剂的有效成份全部是中草药，且组份配伍合理，各味中药的功效如下：铁皮石斛：Dendrobii Officinalis Caulis，本品为兰科植物铁皮石斛Dendrobium officinale Kimura et Migo的干燥茎。为一常用补阴药，具有益胃生津，滋阴清热的功能，用于热病津伤，口干烦渴，胃阴不足，食少干呕，病后虚热不退，阴虚火旺，骨蒸劳热，目暗不明，筋骨痿软。（药典2010）
三七：Radix et Rhizoma notoginseng本品为五加科植物三七Panax notoginseng(Burk.)F.H.Chen的干燥根及根茎。功能主治散瘀止血，消肿定痛。用于咯血，吐血，衄血，便血，崩漏，外伤出血，胸腹剌痛，跌扑肿痛。（药典2005增补版）。
以前工艺铁皮石斛为打粉、葛根加入水提物葛根黄酮。本工艺铁皮石斛和葛根都是通过水提煮后加入水提物。这比以前使铁皮石斛和葛根有效成份更易吸收，更有安全性和符合医学标准。
本申请文件制备得到的颗粒，色泽淡黄色至黄鹤色，微苦，无异味，无肉眼可见外来杂质。微生物指标，菌落总数总数≤30000（GB4789.2），大肠菌群≤0.92（GB4789.3），霉菌和酵母≤50（GB4789.15），金黄色葡萄球菌≤0/25g（GB4789.10），沙门氏菌≤0/25g（GB4789.4）；功效成分测定，粗多糖（以无水葡萄糖计）≥2.5总皂苷，g/100g，指标大于等于1.2。
为了清楚，不描述实际实施例的全部特征，在下列描述中，不详细描述公知的功能和结构，因为它们会使本发明由于不必要的细节而混乱，应当认为在任何实际实施例的开发中，必须做出大量实施细节以实现开发者的特定目标，例如按照有关系统或有关商业的限制，由一个实施例改变为另一个实施例，另外，应当认为这种开发工作可能是复杂和耗费时间的，但是对于本领域技术人员来说仅仅是常规工作。
Claims (3)
1.增强免疫力的铁皮石斛葛根三七颗粒制备工艺，具体采用如下步骤进行制备：
提取、过滤：分别按干重称取1460-1530份铁皮石斛和1400-1510份葛根药材混合在一起，加入8倍药材重量的水，煮提取2次，每次2小时，提取液200目筛过滤，将两次所得滤液合并到一起；
②浓缩、干燥：将滤液减压浓缩，真空度-0.06Mpa，温度70℃，浓缩至相对密度为1.20～1.25（50℃），干燥，温度70℃，真空度-0.07Mpa，干燥12小时，含水量＜6%，得到干膏；
粉碎：铁皮石斛和葛根药材经提取后为干膏，进行破碎粉碎，后过100目筛；
混合：将粉碎得到的干膏粉370-412份三七粉、98-118份冰糖粉、45-56份淀粉、47-55份糊精按重量份数配比混合均匀；
⑤制粒：上述混合粉进行润湿后，60℃干燥条件下过14目钢筛制粒；
⑥整粒：将颗粒过14目筛整粒；
⑦包装：按照产品规格要求进行包装，规格为100袋/包或30袋/盒、每袋1份；
⑧入库：将包装好的产品进行辐照灭菌，按企业标准检验合格后入库。
2.如权利要求1所述增强免疫力的铁皮石斛葛根三七颗粒制备工艺，其特征在于：所述步骤①铁皮石斛和份葛根药材混合在一起，加入8倍药材重量的水，采用煎煮方式进行提取。
3.如权利要求1或2所述增强免疫力的铁皮石斛葛根三七颗粒制备工艺，其特征在于：所述步骤⑤混合粉加75%乙醇进行润湿。
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