CN106692780B - 预防和减轻糖尿病及其并发症的组合物 - Google Patents

预防和减轻糖尿病及其并发症的组合物 Download PDF

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CN106692780B
CN106692780B CN201611201952.5A CN201611201952A CN106692780B CN 106692780 B CN106692780 B CN 106692780B CN 201611201952 A CN201611201952 A CN 201611201952A CN 106692780 B CN106692780 B CN 106692780B
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radix
composition
ginseng
diabetes
complications
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CN106692780A (zh
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隋英祝
崔冉
沈小凯
何兆亮
靖立红
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Zibo Yada Pharmaceutical Ltd By Share Ltd
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Abstract

本发明涉及一种预防和减轻糖尿病及其并发症的组合物，属于医药制品技术领域。所述的组合物为药物，且由以下重量配比的原料制成：人参10～15g，党参38～45g，玄参25～30g，丹参25～30g，白术25～30g，茯苓25～30g，薏米25～30g，枸杞子50～55g，五味子25～30g，麦冬25～35g，天花粉25～30g，三七25～30g，黄芪50～55g，当归10～18g，山药23～28g，山茱萸38～45g，生地黄65～70g，菟丝子50～55g，玫瑰花25～30g，玉竹50～70g。本发明的组合物能够制备成药品，且食用安全，能够有效预防糖尿病及其并发症的发生，具有使用方便、无毒副作用、增强体质的特点。

Description

预防和减轻糖尿病及其并发症的组合物
技术领域
本发明涉及一种预防和减轻糖尿病及其并发症的组合物，属于医药制品技术领域。
背景技术
糖尿病目前已成为导致全球人口死亡的第四大疾病，我国大约有6.5％的人口患有糖尿病，糖尿病的治疗周期长，治疗费用昂贵，这不仅严重影响了患者的生活和生命质量，也给国家和人民带来了沉重的经济负担，因此，有必要开发具有预防或治疗糖尿病的药品具有广泛的经济效益和社会效益。
国内外目前对于糖尿病的预防和治疗主要采用诸如双胍类药、磺酰脲类药、胰岛素等化学药物，但是这些药物存在着以下问题：双胍类药物疗效低，副作用大，久用会产生高乳酸血症；磺酰脲类药物久用会损害肝脏、肾脏，与磺胺类药物发生交叉过敏；胰岛素久用会产生抗体，生物活性降低，剂量增加，产生高胰岛素血症。
糖尿病的主要中医病机是“气阴不足、脾虚湿浊、淤血阻络”，因此治疗糖尿病的中医治则是益气养阴，健脾降浊，活血通络，且中医疗法对于老年2型糖尿病及其并发症的治疗和预防具有疗效稳定、无毒副作用、调节机体内环境、改善体质、增强免疫、减轻胰岛素抵抗状态、调节糖脂代谢、增强糖自稳等优点；糖尿病并发症是由于糖尿病患者长期控制饮食，导致体内营养缺乏，机体更加的虚弱，抗病防病能力下降，从而导致多种病症并发，中医能够对各种并发症进行很好的控制，如糖尿病性肾病、周围神经病变、闭塞性动脉硬化症及肢端坏疽、糖尿病视网膜病变引起的失明等。因此，对于用于治疗和预防糖尿病的中医药物存在着很大需求。
发明内容
本发明的目的是提供一种预防和减轻糖尿病及其并发症的组合物，基于中医对于糖尿病的发病机理和治则，同时结合药用组分的药理，既无毒副作用，又能够有效降低和控制血糖含量。
本发明所述的预防和减轻糖尿病及其并发症的组合物为药物，且由以下重量配比的原料制成：
人参10～15g，党参38～45g，玄参25～30g，丹参25～30g，白术25～30g，茯苓25～30g，薏米25～30g，枸杞子50～55g，五味子25～30g，麦冬25～35g，天花粉25～30g，三七25～30g，黄芪50～55g，当归10～18g，山药23～28g，山茱萸38～45g，生地黄65～70g，菟丝子50～55g，玫瑰花25～30g，玉竹50～70g。
优选地，由以下重量配比的原料制成：
人参13g，党参40g，玄参27g，丹参27g，白术27g，茯苓27g，薏米27g，枸杞子53g，五味子27g，麦冬30g，天花粉27g，三七27g，黄芪53g，当归13g，山药25g，山茱萸40g，生地黄66g，菟丝子53g，玫瑰花27g，玉竹60g。
所述的组合物的制备方法包括以下步骤：
(1)将配比量的玄参、党参、白术、丹参、当归、菟丝子、麦冬、枸杞子、黄芪、天花粉、茯苓和玉竹用5～10倍的水提取2次，每次2h，合并提取液后将提取液浓缩至相对密度为1.2～1.3，然后于45～55℃下进行微波真空干燥，粉碎至120目后得到提取物细粉，备用；
(2)将配比量的三七、薏米、山药、五味子、山茱萸、生地黄、人参、玫瑰花粉碎成120目的细粉，然后将其与步骤(1)中得到的提取物细粉混合均匀，得到预防糖尿病及其并发症的组合物。
该组合物为胶囊、片剂或颗粒剂，作为胶囊使用时，将混匀后的细粉填充1号空心胶囊，包装规格：0.3g/粒；用法：日服两次，4粒/次，温开水送服
本发明的组合物中各类物品的选择除了按糖尿病的中医病机和治则外，还更加注重药理作用和无毒副作用，真正做到有效无毒。
本发明的组合物的功效是预防和减轻2型糖尿病及其并发症，增强免疫力，同时对老年人遗尿、漏尿、尿频、尿液泡沫多也有一定的疗效，且中医认为的燥热内盛、脾虚湿滞、水湿停聚、瘀血阻滞、胃阴阳亏虚、湿热下泛、气血亏虚等都使用。
本发明的组合物中：
(1)具有补气功效的黄芪与具有补血功效的当归相结合，气为血帅，气行则血行；
(2)人参和党参起到益气补中的功效；
(3)白术、茯苓和薏米起到健脾降浊的功效；
(4)三七与玫瑰花相结合能够起到活血化瘀、通络的作用，近代研究证明三七具有双向调节的作用：活血化瘀、止血止痛，三七中含有皂苷甲、皂苷乙、黄酮苷、生物碱等，有明显增加冠脉流量、减低冠脉阻力、降低心肌耗氧率的作用，对血液具有清除“垃圾”的功效；
(5)山茱萸、五味子能够起到增强免疫功能的作用；
(6)枸杞子和生地黄能够起到滋阴补肾的功效；
上述诸药合用共奏预防和减轻糖尿病及其并发症的功效。
典型病例
1、李某某，女，患糖尿病10年，2015年5月就诊时，血糖为8.23mmol/L，尿糖(+++)，经常感冒，浑身乏力，夜尿三次，服用本发明的中药组合物1周后，自感全身有劲，夜尿2次，血糖降至7.0mmol/L，继续服用1个月，夜尿1次，其它症状消失。
2、王某某，男，患糖尿病20年，2014年10月就诊时，血糖为18.5mmol/L，尿糖(++++)，浑身无力，身体消瘦，眼底出血，服用本发明的中药组合物2周后，血糖降至8.9mmol/L，体重增加0.5kg，自感全身有劲，眼底出血也明显改善。
3、陈某某，女，患糖尿病5年，2015年8月就诊时，血糖为8.2mmol/L，尿糖(++)，消渴，多食，多尿，服用本发明的中药组合物1周后，消渴减轻，饭量降低，继续服用3周后，症状全部消失。
本发明的有益效果如下：
本发明的组合物能够制备成药品，且食用安全，能够有效预防糖尿病及其并发症的发生，具有使用方便、无毒副作用、增强体质的特点。
具体实施方式
以下结合实施例对本发明做进一步描述。
实施例1
预防和减轻糖尿病及其并发症的组合物由以下重量配比的原料制成：
人参10g，党参38g，玄参25g，丹参25g，白术25g，茯苓25g，薏米25g，枸杞子50g，五味子25g，麦冬25g，天花粉25g，三七25g，黄芪50g，当归10g，山药23g，山茱萸38g，生地黄65g，菟丝子50g，玫瑰花25g，玉竹50g。
制备方法包括以下步骤：
(1)将配比量的玄参、党参、白术、丹参、当归、菟丝子、麦冬、枸杞子、黄芪、天花粉、茯苓和玉竹用5倍的水提取2次，每次2h，合并提取液后将提取液浓缩至相对密度为1.2，然后于50℃下进行微波真空干燥，粉碎至120目后得到提取物细粉，备用；
(2)将配比量的三七、薏米、山药、五味子、山茱萸、生地黄、人参、玫瑰花粉碎成120目的细粉，然后将其与步骤(1)中得到的提取物细粉混合均匀，得到预防糖尿病及其并发症的组合物。
实施例2
预防和减轻糖尿病及其并发症的组合物由以下重量配比的原料制成：
人参13g，党参40g，玄参27g，丹参27g，白术27g，茯苓27g，薏米27g，枸杞子53g，五味子27g，麦冬30g，天花粉27g，三七27g，黄芪53g，当归13g，山药25g，山茱萸40g，生地黄66g，菟丝子53g，玫瑰花27g，玉竹60g。
制备方法包括以下步骤：
(1)将配比量的玄参、党参、白术、丹参、当归、菟丝子、麦冬、枸杞子、黄芪、天花粉、茯苓和玉竹用8倍的水提取2次，每次2h，合并提取液后将提取液浓缩至相对密度为1.25，然后于50℃下进行微波真空干燥，粉碎至120目后得到提取物细粉，备用；
(2)将配比量的三七、薏米、山药、五味子、山茱萸、生地黄、人参、玫瑰花粉碎成120目的细粉，然后将其与步骤(1)中得到的提取物细粉混合均匀，得到预防糖尿病及其并发症的组合物。
实施例3
预防和减轻糖尿病及其并发症的组合物由以下重量配比的原料制成：
人参15g，党参45g，玄参30g，丹参30g，白术30g，茯苓30g，薏米30g，枸杞子55g，五味子30g，麦冬35g，天花粉30g，三七30g，黄芪55g，当归18g，山药28g，山茱萸45g，生地黄70g，菟丝子55g，玫瑰花30g，玉竹70g。
制备方法包括以下步骤：
(1)将配比量的玄参、党参、白术、丹参、当归、菟丝子、麦冬、枸杞子、黄芪、天花粉、茯苓和玉竹用10倍的水提取2次，每次2h，合并提取液后将提取液浓缩至相对密度为1.3，然后于50℃下进行微波真空干燥，粉碎至120目后得到提取物细粉，备用；
(2)将配比量的三七、薏米、山药、五味子、山茱萸、生地黄、人参、玫瑰花粉碎成120目的细粉，然后将其与步骤(1)中得到的提取物细粉混合均匀，得到预防糖尿病及其并发症的组合物。

Claims (3)

1.一种预防和减轻糖尿病及其并发症的组合物，其特征在于：该组合物为药物，且由以下重量配比的原料制成：
人参10～15g，党参38～45g，玄参25～30g，丹参25～30g，白术25～30g，茯苓25～30g，薏米25～30g，枸杞子50～55g，五味子25～30g，麦冬25～35g，天花粉25～30g，三七25～30g，黄芪50～55g，当归10～18g，山药23～38g，山茱萸38～45g，生地黄65～70g，菟丝子50～55g，玫瑰花25～30g，玉竹50～70g；
该组合物的制备方法包括以下步骤：
(1)将配比量的玄参、党参、白术、丹参、当归、菟丝子、麦冬、枸杞子、黄芪、天花粉、茯苓和玉竹用5～10倍的水提取2次，每次2h，合并提取液后进行浓缩，经微波真空干燥、粉碎后，得到提取物细粉，备用；
(2)将配比量的三七、薏米、山药、五味子、山茱萸、生地黄、人参、玫瑰花粉碎成120目的细粉，然后将其与步骤(1)中得到的提取物细粉混合均匀，得到预防糖尿病及其并发症的组合物；
步骤(1)中将提取液浓缩至相对密度为1.2～1.3，微波真空干燥时的干燥温度为45～55℃，粉碎目数为120目。
2.根据权利要求1所述的预防和减轻糖尿病及其并发症的组合物，其特征在于：由以下重量配比的原料制成：
人参13g，党参40g，玄参27g，丹参27g，白术27g，茯苓27g，薏米27g，枸杞子53g，五味子27g，麦冬30g，天花粉27g，三七27g，黄芪53g，当归13g，山药25g，山茱萸40g，生地黄66g，菟丝子53g，玫瑰花27g，玉竹60g。
3.根据权利要求1所述的预防和减轻糖尿病及其并发症的组合物，其特征在于：该组合物为胶囊、片剂或颗粒剂。
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