CN106146415A - The synthetic method of medicine intermediate 2,4-bis-chloro-5-trifluoromethyl piperazine - Google Patents
The synthetic method of medicine intermediate 2,4-bis-chloro-5-trifluoromethyl piperazine Download PDFInfo
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- CN106146415A CN106146415A CN201510749107.0A CN201510749107A CN106146415A CN 106146415 A CN106146415 A CN 106146415A CN 201510749107 A CN201510749107 A CN 201510749107A CN 106146415 A CN106146415 A CN 106146415A
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- chloro
- bis
- piperazine
- synthetic method
- trifluoromethyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The present invention relates to a kind of medicine intermediate 2, the synthetic method of 4-bis-chloro-5-trifluoromethyl piperazine, with piperazine as raw material, under 2 atmospheric pressure and solvent isopropyl acetone effect, first pass through displacement method at temperature 130 DEG C-150 DEG C to react with chlorion, then by the generation 2 that methylates, 4-bis-chloro-5-trifluoromethyl piperazine.Medicine intermediate 2 of the present invention, the synthetic method of 4-bis-chloro-5-trifluoromethyl piperazine is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 2,4-bis-chloro-5-trifluoromethyl piperazine.
Background technology
2,4-bis-chloro-5-trifluoromethyl piperazines are the initiation materials of many pharmaceutical synthesis, the important intermediate of particularly a lot of diethylenediamine compounds, the domestic at present synthetic method having no this compound of report.
Content of the invention
It is an object of the invention to overcome above-mentioned deficiency, a kind of simple, efficient, medicine intermediate 2 of safety operation, the synthetic method of 4-bis-chloro-5-trifluoromethyl piperazine are provided.
The object of the present invention is achieved like this:
A kind of medicine intermediate 2, the synthetic method of 4-bis-chloro-5-trifluoromethyl piperazine, with piperazine as raw material, under 2 atmospheric pressure and solvent isopropyl acetone effect, first pass through displacement method at temperature 130 DEG C-150 DEG C to react with chlorion, then by the generation 2 that methylates, 4-bis-chloro-5-trifluoromethyl piperazine.
Compared with prior art, the invention has the beneficial effects as follows:
Medicine intermediate 2 of the present invention, the synthetic method of 4-bis-chloro-5-trifluoromethyl piperazine is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 2,4-bis-of the present invention chloro-5-trifluoromethyl piperazine is specific as follows:
With piperazine as raw material, under 2 atmospheric pressure and solvent isopropyl acetone effect, at temperature 130 DEG C-150 DEG C, first pass through displacement method react with chlorion, then by the generation 2 that methylates, 4-bis-chloro-5-trifluoromethyl piperazine.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. a medicine intermediate 2, the synthetic method of 4-bis-chloro-5-trifluoromethyl piperazine, it is characterized in that with piperazine as raw material, under 2 atmospheric pressure and solvent isopropyl acetone effect, first pass through displacement method at temperature 130 DEG C-150 DEG C to react with chlorion, then by the generation 2 that methylates, 4-bis-chloro-5-trifluoromethyl piperazine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749107.0A CN106146415A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 2,4-bis-chloro-5-trifluoromethyl piperazine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749107.0A CN106146415A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 2,4-bis-chloro-5-trifluoromethyl piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106146415A true CN106146415A (en) | 2016-11-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510749107.0A Pending CN106146415A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 2,4-bis-chloro-5-trifluoromethyl piperazine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106146415A (en) |
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2015
- 2015-11-08 CN CN201510749107.0A patent/CN106146415A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |
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| WD01 | Invention patent application deemed withdrawn after publication |