CN106146377A - The synthetic method of medicine intermediate 4-dimethylamino pyrrolidones - Google Patents
The synthetic method of medicine intermediate 4-dimethylamino pyrrolidones Download PDFInfo
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- CN106146377A CN106146377A CN201510749095.1A CN201510749095A CN106146377A CN 106146377 A CN106146377 A CN 106146377A CN 201510749095 A CN201510749095 A CN 201510749095A CN 106146377 A CN106146377 A CN 106146377A
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- Prior art keywords
- pyrrolidones
- dimethylamino
- synthetic method
- medicine intermediate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 4-dimethylamino pyrrolidones, with pyrrolidones as raw material, under the effect of aromatic hydrocarbon solvent, under 2 atmospheric pressure, temperature 180 DEG C-200 DEG C, PH5-6 effect respectively by methylate and amination generate 4-dimethylamino pyrrolidones.The synthetic method of medicine intermediate 4-dimethylamino pyrrolidones of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 4-dimethylamino pyrrolidones.
Background technology
4-dimethylamino pyrrolidones is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of pyrrolidone-2 compounds, the domestic at present synthetic method having no this compound of report.
Content of the invention
It is an object of the invention to overcome above-mentioned deficiency, provide a kind of simple, efficiently, the synthetic method of the medicine intermediate 4-dimethylamino pyrrolidones of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 4-dimethylamino pyrrolidones, with pyrrolidones as raw material, under the effect of aromatic hydrocarbon solvent, under 2 atmospheric pressure, temperature 180 DEG C-200 DEG C, PH5-6 effect respectively by methylate and amination generate 4-dimethylamino pyrrolidones.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 4-dimethylamino pyrrolidones of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 4-dimethylamino pyrrolidones of the present invention is specific as follows:
With pyrrolidones as raw material, under the effect of aromatic hydrocarbon solvent, under 2 atmospheric pressure, temperature 180 DEG C-200 DEG C, PH5-6 effect respectively by methylate and amination generate 4-dimethylamino pyrrolidones.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 4-dimethylamino pyrrolidones, it is characterized in that with pyrrolidones as raw material, under the effect of aromatic hydrocarbon solvent, under 2 atmospheric pressure, temperature 180 DEG C-200 DEG C, PH5-6 effect respectively by methylate and amination generate 4-dimethylamino pyrrolidones.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749095.1A CN106146377A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 4-dimethylamino pyrrolidones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749095.1A CN106146377A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 4-dimethylamino pyrrolidones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106146377A true CN106146377A (en) | 2016-11-23 |
Family
ID=57348122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510749095.1A Pending CN106146377A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 4-dimethylamino pyrrolidones |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106146377A (en) |
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2015
- 2015-11-08 CN CN201510749095.1A patent/CN106146377A/en active Pending
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |