CN106146390A - The synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine - Google Patents
The synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine Download PDFInfo
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- CN106146390A CN106146390A CN201510761466.8A CN201510761466A CN106146390A CN 106146390 A CN106146390 A CN 106146390A CN 201510761466 A CN201510761466 A CN 201510761466A CN 106146390 A CN106146390 A CN 106146390A
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- Prior art keywords
- pyridine
- acetyl
- methyl
- synthetic method
- medicine intermediate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 2-acetyl-4-(2-methyl) pyridine; with pyridine as raw material; under the effect of solvent methanol, respectively by acetylation with methylate at temperature 120 DEG C-150 DEG C, generate 2-acetyl-4-(2-methyl) pyridine.The synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 2-acetyl-4-(2-methyl) pyridine.
Background technology
2-acetyl-4-(2-methyl) pyridine is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of pyridine compounds, the domestic at present synthetic method having no this compound of report.
Content of the invention
It is an object of the invention to overcome above-mentioned deficiency, provide a kind of simple, efficiently, the synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine; with pyridine as raw material; under the effect of solvent methanol, respectively by acetylation with methylate at temperature 120 DEG C-150 DEG C, generate 2-acetyl-4-(2-methyl) pyridine.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine of the present invention is specific as follows:
With pyridine as raw material, under the effect of solvent methanol, respectively by acetylation with methylate at temperature 120 DEG C-150 DEG C, generate 2-acetyl-4-(2-methyl) pyridine.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine; it is characterized in that with pyridine as raw material; under the effect of solvent methanol, respectively by acetylation with methylate at temperature 120 DEG C-150 DEG C, generate 2-acetyl-4-(2-methyl) pyridine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761466.8A CN106146390A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761466.8A CN106146390A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106146390A true CN106146390A (en) | 2016-11-23 |
Family
ID=57348148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510761466.8A Pending CN106146390A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 2-acetyl-4-(2-methyl) pyridine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106146390A (en) |
-
2015
- 2015-11-11 CN CN201510761466.8A patent/CN106146390A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |
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| WD01 | Invention patent application deemed withdrawn after publication |