CN106117107A - The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone - Google Patents
The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone Download PDFInfo
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- CN106117107A CN106117107A CN201510761475.7A CN201510761475A CN106117107A CN 106117107 A CN106117107 A CN 106117107A CN 201510761475 A CN201510761475 A CN 201510761475A CN 106117107 A CN106117107 A CN 106117107A
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- CN
- China
- Prior art keywords
- tertbutyloxycarbonyl
- methyl pyrrolidone
- synthetic method
- medicine intermediate
- present
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone, with ketopyrrolidine as raw material, under 1 atmospheric pressure and solvent acetone effect, at temperature 100 DEG C-130 DEG C, first and butyrolactone ammonification, then generates 1-tertbutyloxycarbonyl-4-methyl pyrrolidone by cyaniding.The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone.
Background technology
1-tertbutyloxycarbonyl-4-methyl pyrrolidone is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of pyrrolidone-2 compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone, with ketopyrrolidine as raw material, under 1 atmospheric pressure and solvent acetone effect, at temperature 100 DEG C-130 DEG C, first and butyrolactone ammonification, then generates 1-tertbutyloxycarbonyl-4-methyl pyrrolidone by cyaniding.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone of the present invention is specific as follows:
With ketopyrrolidine as raw material, under 1 atmospheric pressure and solvent acetone effect, at temperature 100 DEG C-130 DEG C, first and butyrolactone ammonification, then generates 1-tertbutyloxycarbonyl-4-methyl pyrrolidone by cyaniding.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone, it is characterized in that with ketopyrrolidine as raw material, under 1 atmospheric pressure and solvent acetone effect, at temperature 100 DEG C-130 DEG C, first and butyrolactone ammonification, then generates 1-tertbutyloxycarbonyl-4-methyl pyrrolidone by cyaniding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761475.7A CN106117107A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761475.7A CN106117107A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106117107A true CN106117107A (en) | 2016-11-16 |
Family
ID=57471593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510761475.7A Pending CN106117107A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-4-methyl pyrrolidone |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106117107A (en) |
-
2015
- 2015-11-11 CN CN201510761475.7A patent/CN106117107A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |
|
| WD01 | Invention patent application deemed withdrawn after publication |