CN105777606A - Synthesis method of medicine intermediate 1-tert-butyloxycarboryl-2-cyanopyrrolidone - Google Patents
Synthesis method of medicine intermediate 1-tert-butyloxycarboryl-2-cyanopyrrolidone Download PDFInfo
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- CN105777606A CN105777606A CN201410793597.XA CN201410793597A CN105777606A CN 105777606 A CN105777606 A CN 105777606A CN 201410793597 A CN201410793597 A CN 201410793597A CN 105777606 A CN105777606 A CN 105777606A
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- cyanopyrrolidone
- butyloxycarboryl
- tert
- medicine intermediate
- pyrrolidone
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Abstract
The invention relates to a synthesis method of a medicine intermediate 1-tert-butyloxycarboryl-2-cyanopyrrolidone. The method comprises the following steps: ammonifying a raw material pyrrolidone and butanolide at 100-120DEG C under 1atm under the action of acetone, and carrying out a cyanidation reaction to generate 1-tert-butyloxycarboryl-2-cyanopyrrolidone. The synthesis method of the medicine intermediate 1-tert-butyloxycarboryl-2-cyanopyrrolidone has the advantages of simplicity, high efficiency, safe operation, and high practicality in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 1-tertbutyloxycarbonyl-2-cyano pyrrolidone.
Background technology
1-tertbutyloxycarbonyl-2-cyano pyrrolidone is the initiation material of many pharmaceutical synthesis, particularly the important intermediate of a lot of pyrrolidone-2 compounds, at present the domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medicine intermediate 1-tertbutyloxycarbonyl-2-cyano pyrrolidone of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-2-cyano pyrrolidone, with ketopyrrolidine for raw material, under 1 atmospheric pressure and solvent acetone effect, first and butyrolactone ammonification at temperature 100 DEG C-120 DEG C, then pass through cyaniding and generate 1-tertbutyloxycarbonyl-2-cyano pyrrolidone.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-2-cyano pyrrolidone of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-2-cyano pyrrolidone of the present invention is specific as follows:
With ketopyrrolidine for raw material, under 1 atmospheric pressure and solvent acetone effect, first and butyrolactone ammonification at temperature 100 DEG C-120 DEG C, then pass through cyaniding and generate 1-tertbutyloxycarbonyl-2-cyano pyrrolidone.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 1-tertbutyloxycarbonyl-2-cyano pyrrolidone, it is characterized in that with ketopyrrolidine for raw material, under 1 atmospheric pressure and solvent acetone effect, first and butyrolactone ammonification at temperature 100 DEG C-120 DEG C, then passes through cyaniding and generates 1-tertbutyloxycarbonyl-2-cyano pyrrolidone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793597.XA CN105777606A (en) | 2014-12-20 | 2014-12-20 | Synthesis method of medicine intermediate 1-tert-butyloxycarboryl-2-cyanopyrrolidone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793597.XA CN105777606A (en) | 2014-12-20 | 2014-12-20 | Synthesis method of medicine intermediate 1-tert-butyloxycarboryl-2-cyanopyrrolidone |
Publications (1)
| Publication Number | Publication Date |
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| CN105777606A true CN105777606A (en) | 2016-07-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201410793597.XA Pending CN105777606A (en) | 2014-12-20 | 2014-12-20 | Synthesis method of medicine intermediate 1-tert-butyloxycarboryl-2-cyanopyrrolidone |
Country Status (1)
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| CN (1) | CN105777606A (en) |
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2014
- 2014-12-20 CN CN201410793597.XA patent/CN105777606A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160720 |
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| WD01 | Invention patent application deemed withdrawn after publication |