CN105777527A - Synthesis method of medicine intermediate 3-oxocyclobutanecarboxylic acid - Google Patents
Synthesis method of medicine intermediate 3-oxocyclobutanecarboxylic acid Download PDFInfo
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- CN105777527A CN105777527A CN201410793567.9A CN201410793567A CN105777527A CN 105777527 A CN105777527 A CN 105777527A CN 201410793567 A CN201410793567 A CN 201410793567A CN 105777527 A CN105777527 A CN 105777527A
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- medicine intermediate
- carboxylic acid
- oxocyclobutanecarboxylic acid
- synthesis method
- oxo
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Abstract
The invention relates to a synthesis method of a medicine intermediate 3-oxocyclobutanecarboxylic acid. The method comprises the following steps: reacting a raw material carboxylic acid with oxocyclobutane at 120-150DEG C under the action of a solvent methanol, and carrying out an alkylation reaction to generate 3-oxocyclobutanecarboxylic acid. The synthetic method of the medicine intermediate 3-oxocyclobutanecarboxylic acid has the advantages of simplicity, high efficiency, safe operation, and high practicality in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 3-oxo cyclobutane yl carboxylic acid.
Background technology
3-oxo cyclobutane yl carboxylic acid is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of carboxylic acid compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medicine intermediate 3-oxo cyclobutane yl carboxylic acid of safety operation.
The object of the present invention is achieved like this:
The synthetic method of a kind of medicine intermediate 3-oxo cyclobutane yl carboxylic acid, with carboxylic acid as raw material, under solvent methanol effect, first reacts with oxo ring fourth at temperature 120 DEG C-150 DEG C, then generates 3-oxo cyclobutane yl carboxylic acid by alkylation.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 3-oxo cyclobutane yl carboxylic acid of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 3-oxo cyclobutane yl carboxylic acid of the present invention is specific as follows:
With carboxylic acid as raw material, under solvent methanol effect, first react with oxo ring fourth at temperature 120 DEG C-150 DEG C, then generate 3-oxo cyclobutane yl carboxylic acid by alkylation.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 3-oxo cyclobutane yl carboxylic acid, it is characterised in that with carboxylic acid as raw material, under solvent methanol effect, first reacts with oxo ring fourth at temperature 120 DEG C-150 DEG C, then generates 3-oxo cyclobutane yl carboxylic acid by alkylation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793567.9A CN105777527A (en) | 2014-12-20 | 2014-12-20 | Synthesis method of medicine intermediate 3-oxocyclobutanecarboxylic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793567.9A CN105777527A (en) | 2014-12-20 | 2014-12-20 | Synthesis method of medicine intermediate 3-oxocyclobutanecarboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105777527A true CN105777527A (en) | 2016-07-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410793567.9A Pending CN105777527A (en) | 2014-12-20 | 2014-12-20 | Synthesis method of medicine intermediate 3-oxocyclobutanecarboxylic acid |
Country Status (1)
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| CN (1) | CN105777527A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109206311A (en) * | 2018-10-26 | 2019-01-15 | 山东谛爱生物技术有限公司 | A kind of preparation method of 3- oxo cyclobutane yl carboxylic acid |
-
2014
- 2014-12-20 CN CN201410793567.9A patent/CN105777527A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109206311A (en) * | 2018-10-26 | 2019-01-15 | 山东谛爱生物技术有限公司 | A kind of preparation method of 3- oxo cyclobutane yl carboxylic acid |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160720 |
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| WD01 | Invention patent application deemed withdrawn after publication |