CN106117206A - The synthetic method of medicine intermediate 4-trifluoromethyl guanine - Google Patents
The synthetic method of medicine intermediate 4-trifluoromethyl guanine Download PDFInfo
- Publication number
- CN106117206A CN106117206A CN201510761457.9A CN201510761457A CN106117206A CN 106117206 A CN106117206 A CN 106117206A CN 201510761457 A CN201510761457 A CN 201510761457A CN 106117206 A CN106117206 A CN 106117206A
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- CN
- China
- Prior art keywords
- guanine
- synthetic method
- trifluoromethyl
- medicine intermediate
- trifluoromethyl guanine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 4-trifluoromethyl guanine, with guanine as raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then by the generation 4-trifluoromethyl guanine that methylates.The synthetic method of medicine intermediate 4-trifluoromethyl guanine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 4-trifluoromethyl guanine.
Background technology
4-trifluoromethyl guanine is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of guanine compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medicine intermediate 4-trifluoromethyl guanine of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 4-trifluoromethyl guanine, with guanine as raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then by the generation 4-trifluoromethyl guanine that methylates.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 4-trifluoromethyl guanine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 4-trifluoromethyl guanine of the present invention is specific as follows:
With guanine as raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then by the generation 4-trifluoromethyl guanine that methylates.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 4-trifluoromethyl guanine, it is characterized in that with guanine as raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then by the generation 4-trifluoromethyl guanine that methylates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761457.9A CN106117206A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 4-trifluoromethyl guanine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761457.9A CN106117206A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 4-trifluoromethyl guanine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106117206A true CN106117206A (en) | 2016-11-16 |
Family
ID=57471439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510761457.9A Pending CN106117206A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 4-trifluoromethyl guanine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106117206A (en) |
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2015
- 2015-11-11 CN CN201510761457.9A patent/CN106117206A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |
|
| WD01 | Invention patent application deemed withdrawn after publication |