CN106117149A - The synthetic method of medicine intermediate 1,3-bis-chloro-5-trifluoromethyl pyrimidine - Google Patents
The synthetic method of medicine intermediate 1,3-bis-chloro-5-trifluoromethyl pyrimidine Download PDFInfo
- Publication number
- CN106117149A CN106117149A CN201510761453.0A CN201510761453A CN106117149A CN 106117149 A CN106117149 A CN 106117149A CN 201510761453 A CN201510761453 A CN 201510761453A CN 106117149 A CN106117149 A CN 106117149A
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- CN
- China
- Prior art keywords
- chloro
- bis
- synthetic method
- pyrimidine
- trifluoromethyl pyrimidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of medicine intermediate 1, the synthetic method of 3-bis-chloro-5-trifluoromethyl pyrimidine, with pyrimidine as raw material, under 2 atmospheric pressure and solvent isopropyl acetone effect, at temperature 130 DEG C-150 DEG C, first pass through displacement method react with chloride ion, then by the generation 1 that methylates, 3-bis-chloro-5-trifluoromethyl pyrimidine.Medicine intermediate 1 of the present invention, the synthetic method of 3-bis-chloro-5-trifluoromethyl pyrimidine is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 1,3-bis-chloro-5-trifluoromethyl pyrimidine.
Background technology
1,3-bis-chloro-5-trifluoromethyl pyrimidine is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of pyrimidine compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficient, medicine intermediate 1 of safety operation, the synthetic method of 3-bis-chloro-5-trifluoromethyl pyrimidine.
The object of the present invention is achieved like this:
A kind of medicine intermediate 1, the synthetic method of 3-bis-chloro-5-trifluoromethyl pyrimidine, with pyrimidine as raw material, under 2 atmospheric pressure and solvent isopropyl acetone effect, at temperature 130 DEG C-150 DEG C, first pass through displacement method react with chloride ion, then by the generation 1 that methylates, 3-bis-chloro-5-trifluoromethyl pyrimidine.
Compared with prior art, the invention has the beneficial effects as follows:
Medicine intermediate 1 of the present invention, the synthetic method of 3-bis-chloro-5-trifluoromethyl pyrimidine is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 1,3-bis-of the present invention chloro-5-trifluoromethyl pyrimidine is specific as follows:
With pyrimidine as raw material, under 2 atmospheric pressure and solvent isopropyl acetone effect, at temperature 130 DEG C-150 DEG C, first pass through displacement method react with chloride ion, then by the generation 1 that methylates, 3-bis-chloro-5-trifluoromethyl pyrimidine.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. a medicine intermediate 1, the synthetic method of 3-bis-chloro-5-trifluoromethyl pyrimidine, it is characterized in that with pyrimidine as raw material, under 2 atmospheric pressure and solvent isopropyl acetone effect, at temperature 130 DEG C-150 DEG C, first pass through displacement method react with chloride ion, then by the generation 1 that methylates, 3-bis-chloro-5-trifluoromethyl pyrimidine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761453.0A CN106117149A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1,3-bis-chloro-5-trifluoromethyl pyrimidine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761453.0A CN106117149A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1,3-bis-chloro-5-trifluoromethyl pyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106117149A true CN106117149A (en) | 2016-11-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510761453.0A Pending CN106117149A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1,3-bis-chloro-5-trifluoromethyl pyrimidine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106117149A (en) |
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2015
- 2015-11-11 CN CN201510761453.0A patent/CN106117149A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |