CN106146289A - The synthetic method of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt - Google Patents
The synthetic method of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt Download PDFInfo
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- CN106146289A CN106146289A CN201510761467.2A CN201510761467A CN106146289A CN 106146289 A CN106146289 A CN 106146289A CN 201510761467 A CN201510761467 A CN 201510761467A CN 106146289 A CN106146289 A CN 106146289A
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- carboxylic acid
- acid salt
- synthetic method
- oxo
- medicine intermediate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt, with carboxylate as raw material, under solvent methanol effect, first react with oxo ring fourth at temperature 120 DEG C-150 DEG C, then generate 4-oxo cyclobutane yl carboxylic acid salt by alkylation.The synthetic method of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt.
Background technology
4-oxo cyclobutane yl carboxylic acid salt is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of carboxylate compounds, the domestic at present synthetic method having no this compound of report.
Content of the invention
It is an object of the invention to overcome above-mentioned deficiency, provide a kind of simple, efficiently, the synthetic method of the medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt of safety operation.
The object of the present invention is achieved like this:
The synthetic method of a kind of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt, with carboxylate as raw material, under solvent methanol effect, first reacts with oxo ring fourth at temperature 120 DEG C-150 DEG C, then generates 4-oxo cyclobutane yl carboxylic acid salt by alkylation.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt of the present invention is specific as follows:
With carboxylate as raw material, under solvent methanol effect, first react with oxo ring fourth at temperature 120 DEG C-150 DEG C, then generate 4-oxo cyclobutane yl carboxylic acid salt by alkylation.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt, it is characterized in that with carboxylate as raw material, under solvent methanol effect, first react with oxo ring fourth at temperature 120 DEG C-150 DEG C, then generate 4-oxo cyclobutane yl carboxylic acid salt by alkylation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761467.2A CN106146289A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761467.2A CN106146289A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106146289A true CN106146289A (en) | 2016-11-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510761467.2A Pending CN106146289A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 4-oxo cyclobutane yl carboxylic acid salt |
Country Status (1)
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| CN (1) | CN106146289A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109206311A (en) * | 2018-10-26 | 2019-01-15 | 山东谛爱生物技术有限公司 | A kind of preparation method of 3- oxo cyclobutane yl carboxylic acid |
-
2015
- 2015-11-11 CN CN201510761467.2A patent/CN106146289A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109206311A (en) * | 2018-10-26 | 2019-01-15 | 山东谛爱生物技术有限公司 | A kind of preparation method of 3- oxo cyclobutane yl carboxylic acid |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |