CN106117105A - The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone - Google Patents
The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone Download PDFInfo
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- CN106117105A CN106117105A CN201510761437.1A CN201510761437A CN106117105A CN 106117105 A CN106117105 A CN 106117105A CN 201510761437 A CN201510761437 A CN 201510761437A CN 106117105 A CN106117105 A CN 106117105A
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- Prior art keywords
- pyrrolidone
- tertbutyloxycarbonyl
- hydroxyethyl
- trans
- synthetic method
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone, with ketopyrrolidine as raw material, first pass through hydroxyethylation, then, under 1.5 atmospheric pressure and etoh solvent effect, at temperature 150 DEG C-170 DEG C, trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone is generated with butyrolactone ammonification.The synthetic method of medicine intermediate of the present invention trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone.
Background technology
Trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of pyrrolidone-2 compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone, with ketopyrrolidine as raw material, first pass through hydroxyethylation, then, under 1.5 atmospheric pressure and etoh solvent effect, at temperature 150 DEG C-170 DEG C, trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone is generated with butyrolactone ammonification.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate of the present invention trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate of the present invention trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone is specific as follows:
With ketopyrrolidine as raw material, first pass through hydroxyethylation, then under 1.5 atmospheric pressure and etoh solvent effect, at temperature 150 DEG C-170 DEG C, generate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone with butyrolactone ammonification.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone, it is characterized in that with ketopyrrolidine as raw material, first pass through hydroxyethylation, then, under 1.5 atmospheric pressure and etoh solvent effect, at temperature 150 DEG C-170 DEG C, trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone is generated with butyrolactone ammonification.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761437.1A CN106117105A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761437.1A CN106117105A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106117105A true CN106117105A (en) | 2016-11-16 |
Family
ID=57471589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510761437.1A Pending CN106117105A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106117105A (en) |
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2015
- 2015-11-11 CN CN201510761437.1A patent/CN106117105A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |
|
| WD01 | Invention patent application deemed withdrawn after publication |