CN105753771A - A synthetic method of a medical intermediate trans-3-N-boc-aminopiperidine - Google Patents
A synthetic method of a medical intermediate trans-3-N-boc-aminopiperidine Download PDFInfo
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- CN105753771A CN105753771A CN201410793596.5A CN201410793596A CN105753771A CN 105753771 A CN105753771 A CN 105753771A CN 201410793596 A CN201410793596 A CN 201410793596A CN 105753771 A CN105753771 A CN 105753771A
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- CN
- China
- Prior art keywords
- trans
- synthetic method
- aminopiperidine
- boc
- butoxycarbonyl amino
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Abstract
The invention relates to a synthetic method of a medical intermediate trans-3-N-boc-aminopiperidine. The method adopts piperidine as a raw material and generates the trans-3-N-boc-aminopiperidine through amination under 1 atmospheric pressure at 140-160 DEG C under the action of a solvent that is ethanol. The method is simple, efficient, safe in operation and particularly practical in practical production.
Description
Technical field
The present invention relates to the synthetic method of the trans 3-t-butoxycarbonyl amino piperidines of a kind of medicine intermediate.
Background technology
Trans 3-t-butoxycarbonyl amino piperidines is the initiation material of many pharmaceutical synthesis, particularly the important intermediate of a lot of piperidine compounds, at present the domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the trans 3-t-butoxycarbonyl amino piperidines of medicine intermediate of safety operation.
The object of the present invention is achieved like this:
The synthetic method of the trans 3-t-butoxycarbonyl amino piperidines of a kind of medicine intermediate, with piperidines for raw material, under 1 atmospheric pressure and etoh solvent effect, by amination at temperature 140 DEG C-160 DEG C, generates trans 3-t-butoxycarbonyl amino piperidines.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of the trans 3-t-butoxycarbonyl amino piperidines of medicine intermediate of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate of the present invention trans 3-t-butoxycarbonyl amino piperidines is specific as follows:
With piperidines for raw material, under 1 atmospheric pressure and etoh solvent effect, by amination at temperature 140 DEG C-160 DEG C, generate trans 3-t-butoxycarbonyl amino piperidines.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of the trans 3-t-butoxycarbonyl amino piperidines of medicine intermediate, it is characterized in that with piperidines for raw material, under 1 atmospheric pressure and etoh solvent effect, by amination at temperature 140 DEG C-160 DEG C, generate trans 3-t-butoxycarbonyl amino piperidines.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793596.5A CN105753771A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate trans-3-N-boc-aminopiperidine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793596.5A CN105753771A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate trans-3-N-boc-aminopiperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105753771A true CN105753771A (en) | 2016-07-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410793596.5A Pending CN105753771A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate trans-3-N-boc-aminopiperidine |
Country Status (1)
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| CN (1) | CN105753771A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105974036A (en) * | 2016-07-31 | 2016-09-28 | 合肥远志医药科技开发有限公司 | Detection method of aminopyridine isomer |
-
2014
- 2014-12-20 CN CN201410793596.5A patent/CN105753771A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105974036A (en) * | 2016-07-31 | 2016-09-28 | 合肥远志医药科技开发有限公司 | Detection method of aminopyridine isomer |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160713 |