CN105753815A - A synthetic method of a medical intermediate 1-acetyl-4-(2-hydroxyethyl)-piperazine - Google Patents
A synthetic method of a medical intermediate 1-acetyl-4-(2-hydroxyethyl)-piperazine Download PDFInfo
- Publication number
- CN105753815A CN105753815A CN201410793599.9A CN201410793599A CN105753815A CN 105753815 A CN105753815 A CN 105753815A CN 201410793599 A CN201410793599 A CN 201410793599A CN 105753815 A CN105753815 A CN 105753815A
- Authority
- CN
- China
- Prior art keywords
- piperazine
- acetyl
- synthetic method
- hydroxyethyl
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The invention relates to a synthetic method of a medical intermediate 1-acetyl-4-(2-hydroxyethyl)-piperazine. The method adopts piperazine as a raw material and prepares the 1-acetyl-4-(2-hydroxyethyl)-piperazine through acetylation and hydroxymethylation respectively at 120-150 DEG C under the action of a solvent that is methanol. The method is simple, efficient, safe in operation and particularly practical in practical production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 1-acetyl-4-(2-ethoxy) piperazine.
Background technology
1-acetyl-4-(2-ethoxy) piperazine is the initiation material of many pharmaceutical synthesis, particularly the important intermediate of a lot of diethylenediamine compounds, at present the domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of medicine intermediate 1-acetyl-4-(2-ethoxy) piperazine of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 1-acetyl-4-(2-ethoxy) piperazine; with piperazine for raw material; under the effect of solvent methanol, respectively through acetylation and hydroxyethylation at temperature 120 DEG C-150 DEG C, generate 1-acetyl-4-(2-ethoxy) piperazine.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 1-acetyl-4-(2-ethoxy) piperazine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 1-acetyl-4-(2-ethoxy) piperazine of the present invention is specific as follows:
With piperazine for raw material, under the effect of solvent methanol, respectively through acetylation and hydroxyethylation at temperature 120 DEG C-150 DEG C, generate 1-acetyl-4-(2-ethoxy) piperazine.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of medicine intermediate 1-acetyl-4-(2-ethoxy) piperazine; it is characterized in that with piperazine for raw material; under the effect of solvent methanol; respectively through acetylation and hydroxyethylation at temperature 120 DEG C-150 DEG C, generate 1-acetyl-4-(2-ethoxy) piperazine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793599.9A CN105753815A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate 1-acetyl-4-(2-hydroxyethyl)-piperazine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793599.9A CN105753815A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate 1-acetyl-4-(2-hydroxyethyl)-piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105753815A true CN105753815A (en) | 2016-07-13 |
Family
ID=56340665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410793599.9A Pending CN105753815A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate 1-acetyl-4-(2-hydroxyethyl)-piperazine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105753815A (en) |
-
2014
- 2014-12-20 CN CN201410793599.9A patent/CN105753815A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105753815A (en) | A synthetic method of a medical intermediate 1-acetyl-4-(2-hydroxyethyl)-piperazine | |
| CN105753771A (en) | A synthetic method of a medical intermediate trans-3-N-boc-aminopiperidine | |
| CN106117210A (en) | The synthetic method of medicine intermediate hydroxyl 3-hydroxypyrrole pyrimidine | |
| CN106146389A (en) | The synthetic method of medicine intermediate 1-acetyl-4-(2-ethoxy) pyridine | |
| CN105753790A (en) | A synthetic method of a medical intermediate 2,4-dichloro-5-trifluoromethylpyrimidine | |
| CN105777527A (en) | Synthesis method of medicine intermediate 3-oxocyclobutanecarboxylic acid | |
| CN106146375A (en) | The synthetic method of medicine intermediate 1-acetyl-4-(2-ethoxy) pyrrolidines | |
| CN106146363A (en) | The synthetic method of medical material 3-methyl sulfinic acid amine salt | |
| CN106117108A (en) | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-methylpyrrole piperidines | |
| CN105753803A (en) | A synthetic method of a medical intermediate 3-methylmorpholine hydrochloride | |
| CN106117150A (en) | The synthetic method of medicine intermediate trans 3-t-butoxycarbonyl amino piperazine | |
| CN106117158A (en) | The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate | |
| CN106117105A (en) | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone | |
| CN106117208A (en) | The synthetic method of medicine intermediate 5-ethoxy pyrrolopyrimidine | |
| CN106146415A (en) | The synthetic method of medicine intermediate 2,4-bis-chloro-5-trifluoromethyl piperazine | |
| CN106146499A (en) | The synthetic method of medicine intermediate 5-trifluoroethyl guanine | |
| CN106117151A (en) | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine | |
| CN106117122A (en) | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-2-ethoxy pyridine | |
| CN106117134A (en) | The synthetic method of medical material 5-fluoro-2-bromine isonicotinic acid | |
| CN106117102A (en) | The synthetic method of medicine intermediate trans 3-t-butoxycarbonyl amino pyrrolidine | |
| CN105753792A (en) | A synthetic method of a medical intermediate 5-(trifluoromethyl)uracil | |
| CN106117162A (en) | The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate | |
| CN106117135A (en) | The synthetic method of medical material 5-fluoro-2-chloroisonicotinic acid | |
| CN105753760A (en) | A synthetic method of a medical intermediate N-boc-3-pyrrolidinone | |
| CN106117209A (en) | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-4-pyrrolopyrimidine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160713 |