CN105753792A - A synthetic method of a medical intermediate 5-(trifluoromethyl)uracil - Google Patents
A synthetic method of a medical intermediate 5-(trifluoromethyl)uracil Download PDFInfo
- Publication number
- CN105753792A CN105753792A CN201410793592.7A CN201410793592A CN105753792A CN 105753792 A CN105753792 A CN 105753792A CN 201410793592 A CN201410793592 A CN 201410793592A CN 105753792 A CN105753792 A CN 105753792A
- Authority
- CN
- China
- Prior art keywords
- uracil
- trifluoromethyl
- synthetic method
- medical intermediate
- pass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Saccharide Compounds (AREA)
Abstract
The invention relates to a synthetic method of a medical intermediate 5-(trifluoromethyl)uracil. The method adopts uracil as a raw material and includes reacting with a fluoride through a substitution process under 1.6 atmospheric pressures at 120-150 DEG C under the action of solvents which are methanol and acetone, and methylating to generate the 5-(trifluoromethyl)uracil. The method is simple, efficient, safe in operation and particularly practical in practical production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 5-trifluoromethyl uracil.
Background technology
5-trifluoromethyl uracil is the initiation material of many pharmaceutical synthesis, particularly the important intermediate of a lot of uracil compounds, at present the domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medicine intermediate 5-trifluoromethyl uracil of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 5-trifluoromethyl uracil, with uracil for raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then pass through the generation 5-trifluoromethyl uracil that methylates.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 5-trifluoromethyl uracil of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 5-trifluoromethyl uracil of the present invention is specific as follows:
With uracil for raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then pass through the generation 5-trifluoromethyl uracil that methylates.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 5-trifluoromethyl uracil, it is characterized in that with uracil for raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then pass through the generation 5-trifluoromethyl uracil that methylates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793592.7A CN105753792A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate 5-(trifluoromethyl)uracil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793592.7A CN105753792A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate 5-(trifluoromethyl)uracil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105753792A true CN105753792A (en) | 2016-07-13 |
Family
ID=56340642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410793592.7A Pending CN105753792A (en) | 2014-12-20 | 2014-12-20 | A synthetic method of a medical intermediate 5-(trifluoromethyl)uracil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105753792A (en) |
-
2014
- 2014-12-20 CN CN201410793592.7A patent/CN105753792A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105753792A (en) | A synthetic method of a medical intermediate 5-(trifluoromethyl)uracil | |
| CN105753790A (en) | A synthetic method of a medical intermediate 2,4-dichloro-5-trifluoromethylpyrimidine | |
| CN106146363A (en) | The synthetic method of medical material 3-methyl sulfinic acid amine salt | |
| CN106146499A (en) | The synthetic method of medicine intermediate 5-trifluoroethyl guanine | |
| CN106117206A (en) | The synthetic method of medicine intermediate 4-trifluoromethyl guanine | |
| CN106117149A (en) | The synthetic method of medicine intermediate 1,3-bis-chloro-5-trifluoromethyl pyrimidine | |
| CN106117210A (en) | The synthetic method of medicine intermediate hydroxyl 3-hydroxypyrrole pyrimidine | |
| CN105753771A (en) | A synthetic method of a medical intermediate trans-3-N-boc-aminopiperidine | |
| CN105777527A (en) | Synthesis method of medicine intermediate 3-oxocyclobutanecarboxylic acid | |
| CN106146415A (en) | The synthetic method of medicine intermediate 2,4-bis-chloro-5-trifluoromethyl piperazine | |
| CN106117110A (en) | The synthetic method of medical material 3-ethyl-L-Trp | |
| CN106117208A (en) | The synthetic method of medicine intermediate 5-ethoxy pyrrolopyrimidine | |
| CN105753815A (en) | A synthetic method of a medical intermediate 1-acetyl-4-(2-hydroxyethyl)-piperazine | |
| CN105753760A (en) | A synthetic method of a medical intermediate N-boc-3-pyrrolidinone | |
| CN106146382A (en) | The synthetic method of medical material 2-methyl-L-tryptophan | |
| CN105753803A (en) | A synthetic method of a medical intermediate 3-methylmorpholine hydrochloride | |
| CN105753754A (en) | A synthetic method of a medicine raw material tert-butylsulfinamide | |
| CN105753680A (en) | A synthetic method of a medicine raw material 3,3-dimethylcyclohexanone | |
| CN106117105A (en) | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-3-hydroxyethyl-pyrrolidone | |
| CN106146389A (en) | The synthetic method of medicine intermediate 1-acetyl-4-(2-ethoxy) pyridine | |
| CN106117158A (en) | The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate | |
| CN105753729A (en) | A synthetic method of a medicine raw material 3-nitro-L-tyrosine | |
| CN106117122A (en) | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-2-ethoxy pyridine | |
| CN106117029A (en) | The synthetic method of medical material 3-hydrochloric acid-2-fluorobenzene acetaldehyde | |
| CN106117106A (en) | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-ethyl pyrrolidone |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160713 |