CN106117158A - The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate - Google Patents
The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate Download PDFInfo
- Publication number
- CN106117158A CN106117158A CN201510749092.8A CN201510749092A CN106117158A CN 106117158 A CN106117158 A CN 106117158A CN 201510749092 A CN201510749092 A CN 201510749092A CN 106117158 A CN106117158 A CN 106117158A
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- China
- Prior art keywords
- hydrochlorate
- hydroxymorpholine
- synthetic method
- medicine intermediate
- present
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 2-hydroxymorpholine hydrochlorate, with hydrochlorate as raw material, under solvent acetone effect, first react with morphine at temperature 100 DEG C-130 DEG C, then by the generation 2-hydroxymorpholine hydrochlorate that methylates.The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 2-hydroxymorpholine hydrochlorate.
Background technology
2-hydroxymorpholine hydrochlorate is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of hydrochloride compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medicine intermediate 2-hydroxymorpholine hydrochlorate of safety operation.
The object of the present invention is achieved like this:
The synthetic method of a kind of medicine intermediate 2-hydroxymorpholine hydrochlorate, with hydrochlorate as raw material, under solvent acetone effect, first reacts with morphine at temperature 100 DEG C-130 DEG C, then by the generation 2-hydroxymorpholine hydrochlorate that methylates.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate of the present invention is specific as follows:
With hydrochlorate as raw material, under solvent acetone effect, first react with morphine at temperature 100 DEG C-130 DEG C, then by the generation 2-hydroxymorpholine hydrochlorate that methylates.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 2-hydroxymorpholine hydrochlorate, it is characterised in that with hydrochlorate as raw material, under solvent acetone effect, first reacts with morphine at temperature 100 DEG C-130 DEG C, then by the generation 2-hydroxymorpholine hydrochlorate that methylates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749092.8A CN106117158A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749092.8A CN106117158A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106117158A true CN106117158A (en) | 2016-11-16 |
Family
ID=57471537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510749092.8A Pending CN106117158A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 2-hydroxymorpholine hydrochlorate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106117158A (en) |
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2015
- 2015-11-08 CN CN201510749092.8A patent/CN106117158A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |