CN106117162A - The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate - Google Patents
The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate Download PDFInfo
- Publication number
- CN106117162A CN106117162A CN201510761454.5A CN201510761454A CN106117162A CN 106117162 A CN106117162 A CN 106117162A CN 201510761454 A CN201510761454 A CN 201510761454A CN 106117162 A CN106117162 A CN 106117162A
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- CN
- China
- Prior art keywords
- hydrochlorate
- synthetic method
- hydroxyethyl morpholine
- medicine intermediate
- morpholine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate, with hydrochlorate as raw material, under solvent acetone effect, first react with morphine at temperature 100 DEG C-130 DEG C, then by the generation 1-hydroxyethyl morpholine hydrochlorate that methylates.The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate.
Background technology
1-hydroxyethyl morpholine hydrochlorate is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of hydrochloride compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medicine intermediate 1-hydroxyethyl morpholine hydrochlorate of safety operation.
The object of the present invention is achieved like this:
The synthetic method of a kind of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate, with hydrochlorate as raw material, under solvent acetone effect, first reacts with morphine at temperature 100 DEG C-130 DEG C, then by the generation 1-hydroxyethyl morpholine hydrochlorate that methylates.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate of the present invention is specific as follows:
With hydrochlorate as raw material, under solvent acetone effect, first react with morphine at temperature 100 DEG C-130 DEG C, then by the generation 1-hydroxyethyl morpholine hydrochlorate that methylates.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 1-hydroxyethyl morpholine hydrochlorate, it is characterised in that with hydrochlorate as raw material, under solvent acetone effect, first reacts with morphine at temperature 100 DEG C-130 DEG C, then by the generation 1-hydroxyethyl morpholine hydrochlorate that methylates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761454.5A CN106117162A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761454.5A CN106117162A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106117162A true CN106117162A (en) | 2016-11-16 |
Family
ID=57471441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510761454.5A Pending CN106117162A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate 1-hydroxyethyl morpholine hydrochlorate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106117162A (en) |
-
2015
- 2015-11-11 CN CN201510761454.5A patent/CN106117162A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |
|
| WD01 | Invention patent application deemed withdrawn after publication |