CN106146499A - The synthetic method of medicine intermediate 5-trifluoroethyl guanine - Google Patents
The synthetic method of medicine intermediate 5-trifluoroethyl guanine Download PDFInfo
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- CN106146499A CN106146499A CN201510749100.9A CN201510749100A CN106146499A CN 106146499 A CN106146499 A CN 106146499A CN 201510749100 A CN201510749100 A CN 201510749100A CN 106146499 A CN106146499 A CN 106146499A
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- China
- Prior art keywords
- guanine
- trifluoroethyl
- synthetic method
- medicine intermediate
- present
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 5-trifluoroethyl guanine, with guanine as raw material, under the effect of solvent methanol and acetone, first pass through displacement method at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C to react with fluoride, then by the generation 5-trifluoroethyl guanine that methylates.The synthetic method of medicine intermediate 5-trifluoroethyl guanine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 5-trifluoroethyl guanine.
Background technology
5-trifluoroethyl guanine is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of guanine compounds, the domestic at present synthetic method having no this compound of report.
Content of the invention
It is an object of the invention to overcome above-mentioned deficiency, provide a kind of simple, efficiently, the synthetic method of the medicine intermediate 5-trifluoroethyl guanine of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 5-trifluoroethyl guanine, with guanine as raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then by the generation 5-trifluoroethyl guanine that methylates.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 5-trifluoroethyl guanine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 5-trifluoroethyl guanine of the present invention is specific as follows:
With guanine as raw material, under the effect of solvent methanol and acetone, at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C, first pass through displacement method react with fluoride, then by the generation 5-trifluoroethyl guanine that methylates.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate 5-trifluoroethyl guanine, it is characterized in that with guanine as raw material, under the effect of solvent methanol and acetone, first pass through displacement method at 1.6 atmospheric pressure, temperature 120 DEG C-150 DEG C to react with fluoride, then by the generation 5-trifluoroethyl guanine that methylates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749100.9A CN106146499A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 5-trifluoroethyl guanine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749100.9A CN106146499A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 5-trifluoroethyl guanine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106146499A true CN106146499A (en) | 2016-11-23 |
Family
ID=57348114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510749100.9A Pending CN106146499A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 5-trifluoroethyl guanine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106146499A (en) |
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2015
- 2015-11-08 CN CN201510749100.9A patent/CN106146499A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |
|
| WD01 | Invention patent application deemed withdrawn after publication |