CN106117151A - The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine - Google Patents
The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine Download PDFInfo
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- CN106117151A CN106117151A CN201510749105.1A CN201510749105A CN106117151A CN 106117151 A CN106117151 A CN 106117151A CN 201510749105 A CN201510749105 A CN 201510749105A CN 106117151 A CN106117151 A CN 106117151A
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- China
- Prior art keywords
- piperazine
- tertbutyloxycarbonyl
- carbamyl
- methoxymethyl
- synthetic method
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine; with piperazine as raw material; under etoh solvent effect; respectively by methylating and carbamoylation at temperature 100 DEG C-110 DEG C, generate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine.The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine.
Background technology
1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of diethylenediamine compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine; with piperazine as raw material; under etoh solvent effect; respectively by methylating and carbamoylation at temperature 100 DEG C-110 DEG C, generate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine of the present invention is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine of the present invention is specific as follows:
With piperazine as raw material, under etoh solvent effect, respectively by methylating and carbamoylation at temperature 100 DEG C-110 DEG C, generate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine; it is characterized in that with piperazine as raw material; under etoh solvent effect; respectively by methylating and carbamoylation at temperature 100 DEG C-110 DEG C, generate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749105.1A CN106117151A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749105.1A CN106117151A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106117151A true CN106117151A (en) | 2016-11-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510749105.1A Pending CN106117151A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medicine intermediate 1-tertbutyloxycarbonyl-3-(methoxymethyl-carbamyl) piperazine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106117151A (en) |
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2015
- 2015-11-08 CN CN201510749105.1A patent/CN106117151A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |