CN106117134A - The synthetic method of medical material 5-fluoro-2-bromine isonicotinic acid - Google Patents
The synthetic method of medical material 5-fluoro-2-bromine isonicotinic acid Download PDFInfo
- Publication number
- CN106117134A CN106117134A CN201510749089.6A CN201510749089A CN106117134A CN 106117134 A CN106117134 A CN 106117134A CN 201510749089 A CN201510749089 A CN 201510749089A CN 106117134 A CN106117134 A CN 106117134A
- Authority
- CN
- China
- Prior art keywords
- fluoro
- isonicotinic acid
- synthetic method
- medical material
- bromine isonicotinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medical material 5-fluoro-2-bromine isonicotinic acid, with 2,5-dibromo pyridine is raw material, utilizes displacement method to prepare 5-fluoro-2-bromopyridine under certain solvent and catalyst action, the most further by hydroxylating, generate 5-fluoro-2-bromine isonicotinic acid.The synthetic method of medical material 5-of the present invention fluoro-2-bromine isonicotinic acid is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medical material 5-fluoro-2-bromine isonicotinic acid.
Background technology
5-fluoro-2-bromine isonicotinic acid is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of pyridine compounds, the most domestic synthetic method having no this compound of report.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of simple, efficiently, the synthetic method of the medical material 5-fluoro-2-bromine isonicotinic acid of safety operation.
The object of the present invention is achieved like this:
The synthetic method of a kind of medical material 5-fluoro-2-bromine isonicotinic acid, with 2,5-dibromo pyridine is raw material, utilizes displacement method to prepare 5-fluoro-2-bromopyridine, the most further by hydroxylating, generate 5-fluoro-2-bromine isonicotinic acid under certain solvent and catalyst action.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medical material 5-of the present invention fluoro-2-bromine isonicotinic acid is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medical material 5-of the present invention fluoro-2-bromine isonicotinic acid is specific as follows:
With 2,5-dibromo pyridine is raw material, utilizes displacement method to prepare 5-fluoro-2-bromopyridine, the most further by hydroxylating, generate 5-fluoro-2-bromine isonicotinic acid under certain solvent and catalyst action.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medical material 5-fluoro-2-bromine isonicotinic acid, it is characterized in that with 2,5-dibromo pyridine is raw material, utilizes displacement method to prepare 5-fluoro-2-bromopyridine under certain solvent and catalyst action, the most further by hydroxylating, generate 5-fluoro-2-bromine isonicotinic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749089.6A CN106117134A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medical material 5-fluoro-2-bromine isonicotinic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749089.6A CN106117134A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medical material 5-fluoro-2-bromine isonicotinic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106117134A true CN106117134A (en) | 2016-11-16 |
Family
ID=57471603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510749089.6A Pending CN106117134A (en) | 2015-11-08 | 2015-11-08 | The synthetic method of medical material 5-fluoro-2-bromine isonicotinic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106117134A (en) |
-
2015
- 2015-11-08 CN CN201510749089.6A patent/CN106117134A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161116 |