CN106146376A - The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone - Google Patents
The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone Download PDFInfo
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- CN106146376A CN106146376A CN201510761451.1A CN201510761451A CN106146376A CN 106146376 A CN106146376 A CN 106146376A CN 201510761451 A CN201510761451 A CN 201510761451A CN 106146376 A CN106146376 A CN 106146376A
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- CN
- China
- Prior art keywords
- tertbutyloxycarbonyl
- methyl pyrrolidone
- trans
- synthetic method
- medicine intermediate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
Abstract
The present invention relates to the synthetic method of a kind of medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone, with pyrrolidones as raw material, first pass through and methylate, then, under 1.5 atmospheric pressure and etoh solvent effect, at temperature 150 DEG C-170 DEG C, trans tertbutyloxycarbonyl-2-methyl pyrrolidone is generated with butyrolactone ammonification.The synthetic method of medicine intermediate of the present invention trans tertbutyloxycarbonyl-2-methyl pyrrolidone is simple, efficient, and operates safety, very useful in concrete production.
Description
Technical field
The present invention relates to the synthetic method of a kind of medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone.
Background technology
Trans tertbutyloxycarbonyl-2-methyl pyrrolidone is the initiation material of many pharmaceutical synthesis, the important intermediate of particularly a lot of pyrrolidone-2 compounds, the domestic at present synthetic method having no this compound of report.
Content of the invention
It is an object of the invention to overcome above-mentioned deficiency, provide a kind of simple, efficiently, the synthetic method of the medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone of safety operation.
The object of the present invention is achieved like this:
A kind of synthetic method of medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone, with pyrrolidones as raw material, first pass through and methylate, then, under 1.5 atmospheric pressure and etoh solvent effect, at temperature 150 DEG C-170 DEG C, trans tertbutyloxycarbonyl-2-methyl pyrrolidone is generated with butyrolactone ammonification.
Compared with prior art, the invention has the beneficial effects as follows:
The synthetic method of medicine intermediate of the present invention trans tertbutyloxycarbonyl-2-methyl pyrrolidone is simple, efficient, and operates safety, very useful in concrete production.
Detailed description of the invention
The synthetic method of medicine intermediate of the present invention trans tertbutyloxycarbonyl-2-methyl pyrrolidone is specific as follows:
With pyrrolidones as raw material, first pass through and methylate, then under 1.5 atmospheric pressure and etoh solvent effect, at temperature 150 DEG C-170 DEG C, generate trans tertbutyloxycarbonyl-2-methyl pyrrolidone with butyrolactone ammonification.The purity of this crude product can meet general reaction requirement, can direct plunge in reaction.
Claims (1)
1. the synthetic method of a medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone, it is characterized in that with pyrrolidones as raw material, first pass through and methylate, then, under 1.5 atmospheric pressure and etoh solvent effect, at temperature 150 DEG C-170 DEG C, trans tertbutyloxycarbonyl-2-methyl pyrrolidone is generated with butyrolactone ammonification.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761451.1A CN106146376A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510761451.1A CN106146376A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106146376A true CN106146376A (en) | 2016-11-23 |
Family
ID=57348124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510761451.1A Pending CN106146376A (en) | 2015-11-11 | 2015-11-11 | The synthetic method of medicine intermediate trans tertbutyloxycarbonyl-2-methyl pyrrolidone |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106146376A (en) |
-
2015
- 2015-11-11 CN CN201510761451.1A patent/CN106146376A/en active Pending
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161123 |