CN106103445B - 作为cdk抑制剂的吡唑并[1,5-a]嘧啶-5,7-二胺化合物和它们的治疗用途 - Google Patents

作为cdk抑制剂的吡唑并[1,5-a]嘧啶-5,7-二胺化合物和它们的治疗用途 Download PDF

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Publication number
CN106103445B
CN106103445B CN201580011502.7A CN201580011502A CN106103445B CN 106103445 B CN106103445 B CN 106103445B CN 201580011502 A CN201580011502 A CN 201580011502A CN 106103445 B CN106103445 B CN 106103445B
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Chinese (zh)
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CN106103445A (zh
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亚历山大·波恩德克
塞巴斯蒂安·克罗尔
安东尼·巴雷特
马修·富克特
布赖恩·斯拉弗
西马克·阿里
查尔斯·库姆斯
詹姆士·帕特里克·希德尔
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Ip2 Ipo Innovation Co Ltd
Emory University
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Imperial Innovations Ltd
Cancer Research Technology Ltd
Emory University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201580011502.7A 2014-02-21 2015-02-20 作为cdk抑制剂的吡唑并[1,5-a]嘧啶-5,7-二胺化合物和它们的治疗用途 Active CN106103445B (zh)

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Application Number Priority Date Filing Date Title
GB201403093A GB201403093D0 (en) 2014-02-21 2014-02-21 Therapeutic compounds and their use
GB1403093.6 2014-02-21
PCT/GB2015/050494 WO2015124941A1 (en) 2014-02-21 2015-02-20 Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as cdk inhibitors and their therapeutic use

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CN106103445A CN106103445A (zh) 2016-11-09
CN106103445B true CN106103445B (zh) 2019-08-09

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CA (1) CA2939786C (enExample)
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GB (1) GB201403093D0 (enExample)
HR (1) HRP20190685T1 (enExample)
HU (1) HUE043122T2 (enExample)
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RS (1) RS58704B1 (enExample)
SI (1) SI3107914T1 (enExample)
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WO (1) WO2015124941A1 (enExample)

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BR112020026748A2 (pt) 2018-06-29 2021-03-30 Kinnate Biopharma Inc. Inibidores de quinases dependentes de ciclina
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WO2021003517A1 (en) * 2019-07-10 2021-01-14 Aucentra Therapeutics Pty Ltd Derivatives of 4-(imidazo[l,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin- 2-amine as therapeutic agents
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GB201918541D0 (en) * 2019-12-16 2020-01-29 Carrick Therapeutics Ltd Therapeutic compounds and their use
WO2021176045A1 (en) * 2020-03-06 2021-09-10 Bayer Aktiengesellschaft Imidazotriazines acting on cancer via inhibition of cdk12
US20230158159A1 (en) * 2020-04-24 2023-05-25 Massachusetts Institute Of Technology Chimeric degraders of cyclin-dependent kinase 9 and uses thereof
CA3206043A1 (en) * 2021-01-22 2022-07-28 Zhiming Zhao Substituted pyrazolo[1,5-a]pyrimidin-7-amine derivative, composition and pharmaceutical use thereof
TW202309030A (zh) 2021-05-07 2023-03-01 美商凱麥拉醫療公司 Cdk2降解劑及其用途
GB202108572D0 (en) * 2021-06-16 2021-07-28 Carrick Therapeutics Ltd Therapeutic compounds and their use
WO2023001061A1 (en) * 2021-07-17 2023-01-26 Jingrui Biopharma Co., Ltd. Cdk7 selective inhibitors as anticancer agents
US20250059193A1 (en) * 2021-11-24 2025-02-20 Kronos Bio, Inc. Polymorphic and salt forms of (1s,3s)-n1-(5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl) cyclopentane-1,3-diamine
WO2024102447A1 (en) * 2022-11-10 2024-05-16 Emory University Uses of hydroimidazopyridopyrimidinone derivatives for managing aneurysms or other vascular conditions or diseases
WO2024174949A1 (zh) * 2023-02-20 2024-08-29 江苏正大丰海制药有限公司 作为cdk7激酶抑制剂的杂芳环化合物及其制备和应用
CN120712267A (zh) * 2023-02-21 2025-09-26 杭州德睿智药科技有限公司 作为CDKs抑制剂的新型并杂环类新化合物及其应用
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BR112016018633A2 (enExample) 2017-08-08
PT3107914T (pt) 2019-05-20
CN106103445A (zh) 2016-11-09
SI3107914T1 (sl) 2019-05-31
CA2939786C (en) 2022-03-08
US10414772B2 (en) 2019-09-17
DK3107914T3 (en) 2019-04-29
EP3107914A1 (en) 2016-12-28
ME03427B (me) 2020-01-20
US20200055862A1 (en) 2020-02-20
CY1121588T1 (el) 2020-05-29
CA2939786A1 (en) 2015-08-27
AU2015220560A1 (en) 2016-10-06
EP3107914B1 (en) 2019-01-30
TR201905647T4 (tr) 2019-05-21
AU2015220560B2 (en) 2019-05-16
US20160362410A1 (en) 2016-12-15
LT3107914T (lt) 2019-05-27
RS58704B1 (sr) 2019-06-28
JP2017506250A (ja) 2017-03-02
SMT201900266T1 (it) 2019-07-11
EP3107914B8 (en) 2019-07-17
PL3107914T3 (pl) 2019-09-30
US11566029B2 (en) 2023-01-31
US9932344B2 (en) 2018-04-03
ES2721268T3 (es) 2019-07-30
HRP20190685T1 (hr) 2019-06-14
WO2015124941A1 (en) 2015-08-27
NZ724323A (en) 2022-02-25
BR112016018633B1 (pt) 2022-08-30
US20180273540A1 (en) 2018-09-27
US10927119B2 (en) 2021-02-23
JP6498212B2 (ja) 2019-04-10
HUE043122T2 (hu) 2019-08-28
GB201403093D0 (en) 2014-04-09
US20210253583A1 (en) 2021-08-19

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Address after: England Atsushi

Co-patentee after: British Emperor Innovation Co., Ltd.

Patentee after: IP2 IPO Innovation Co., Ltd.

Co-patentee after: Emory University

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Co-patentee before: British Emperor Innovation Co., Ltd.

Patentee before: Cancer Research Technology Co., Ltd.

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