DK3107914T3 - PYRAZOLO [1,5-A] PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THERAPEUTIC APPLICATION THEREOF - Google Patents

PYRAZOLO [1,5-A] PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THERAPEUTIC APPLICATION THEREOF Download PDF

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Publication number
DK3107914T3
DK3107914T3 DK15706282.9T DK15706282T DK3107914T3 DK 3107914 T3 DK3107914 T3 DK 3107914T3 DK 15706282 T DK15706282 T DK 15706282T DK 3107914 T3 DK3107914 T3 DK 3107914T3
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independently
compound according
ppda
compound
piperazino
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DK15706282.9T
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Danish (da)
English (en)
Inventor
Alexander Bondke
Sebastian Kroll
Anthony Barrett
Matthew Fuchter
Simak Ali
Charles Coombes
James Patrick Snyder
Brian Slafer
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Cancer Research Tech Ltd
Univ Emory
Ip2Ipo Innovations Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK15706282.9T 2014-02-21 2015-02-20 PYRAZOLO [1,5-A] PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THERAPEUTIC APPLICATION THEREOF DK3107914T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201403093A GB201403093D0 (en) 2014-02-21 2014-02-21 Therapeutic compounds and their use
PCT/GB2015/050494 WO2015124941A1 (en) 2014-02-21 2015-02-20 Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as cdk inhibitors and their therapeutic use

Publications (1)

Publication Number Publication Date
DK3107914T3 true DK3107914T3 (en) 2019-04-29

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DK15706282.9T DK3107914T3 (en) 2014-02-21 2015-02-20 PYRAZOLO [1,5-A] PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THERAPEUTIC APPLICATION THEREOF

Country Status (23)

Country Link
US (4) US9932344B2 (enExample)
EP (1) EP3107914B8 (enExample)
JP (1) JP6498212B2 (enExample)
CN (1) CN106103445B (enExample)
AU (1) AU2015220560B2 (enExample)
BR (1) BR112016018633B1 (enExample)
CA (1) CA2939786C (enExample)
CY (1) CY1121588T1 (enExample)
DK (1) DK3107914T3 (enExample)
ES (1) ES2721268T3 (enExample)
GB (1) GB201403093D0 (enExample)
HR (1) HRP20190685T1 (enExample)
HU (1) HUE043122T2 (enExample)
LT (1) LT3107914T (enExample)
ME (1) ME03427B (enExample)
NZ (1) NZ724323A (enExample)
PL (1) PL3107914T3 (enExample)
PT (1) PT3107914T (enExample)
RS (1) RS58704B1 (enExample)
SI (1) SI3107914T1 (enExample)
SM (1) SMT201900266T1 (enExample)
TR (1) TR201905647T4 (enExample)
WO (1) WO2015124941A1 (enExample)

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GB201918541D0 (en) * 2019-12-16 2020-01-29 Carrick Therapeutics Ltd Therapeutic compounds and their use
US20230106032A1 (en) * 2020-03-06 2023-04-06 Bayer Aktiengesellschaft Imidazotriazines acting on cancer via inhibition of cdk12
US20230158159A1 (en) * 2020-04-24 2023-05-25 Massachusetts Institute Of Technology Chimeric degraders of cyclin-dependent kinase 9 and uses thereof
AU2022211514B2 (en) * 2021-01-22 2024-06-13 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Substituted pyrazolo[1,5-a]pyrimidine-7-amine derivative, and compositions and medical use thereof
AU2022271290A1 (en) 2021-05-07 2023-11-23 Kymera Therapeutics, Inc. Cdk2 degraders and uses thereof
GB202108572D0 (en) * 2021-06-16 2021-07-28 Carrick Therapeutics Ltd Therapeutic compounds and their use
WO2023001061A1 (en) * 2021-07-17 2023-01-26 Jingrui Biopharma Co., Ltd. Cdk7 selective inhibitors as anticancer agents
US20250059193A1 (en) * 2021-11-24 2025-02-20 Kronos Bio, Inc. Polymorphic and salt forms of (1s,3s)-n1-(5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl) cyclopentane-1,3-diamine
WO2024102447A1 (en) * 2022-11-10 2024-05-16 Emory University Uses of hydroimidazopyridopyrimidinone derivatives for managing aneurysms or other vascular conditions or diseases
WO2024174949A1 (zh) * 2023-02-20 2024-08-29 江苏正大丰海制药有限公司 作为cdk7激酶抑制剂的杂芳环化合物及其制备和应用
WO2024175024A1 (zh) * 2023-02-21 2024-08-29 杭州德睿智药科技有限公司 作为CDKs抑制剂的新型并杂环类新化合物及其应用
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Publication number Publication date
US10414772B2 (en) 2019-09-17
ES2721268T3 (es) 2019-07-30
WO2015124941A1 (en) 2015-08-27
PT3107914T (pt) 2019-05-20
US20210253583A1 (en) 2021-08-19
CA2939786C (en) 2022-03-08
PL3107914T3 (pl) 2019-09-30
CN106103445B (zh) 2019-08-09
SI3107914T1 (sl) 2019-05-31
RS58704B1 (sr) 2019-06-28
US20160362410A1 (en) 2016-12-15
GB201403093D0 (en) 2014-04-09
AU2015220560A1 (en) 2016-10-06
HUE043122T2 (hu) 2019-08-28
US20200055862A1 (en) 2020-02-20
ME03427B (me) 2020-01-20
BR112016018633B1 (pt) 2022-08-30
AU2015220560B2 (en) 2019-05-16
US10927119B2 (en) 2021-02-23
EP3107914A1 (en) 2016-12-28
EP3107914B1 (en) 2019-01-30
EP3107914B8 (en) 2019-07-17
US11566029B2 (en) 2023-01-31
HRP20190685T1 (hr) 2019-06-14
US20180273540A1 (en) 2018-09-27
BR112016018633A2 (enExample) 2017-08-08
CY1121588T1 (el) 2020-05-29
TR201905647T4 (tr) 2019-05-21
CN106103445A (zh) 2016-11-09
LT3107914T (lt) 2019-05-27
CA2939786A1 (en) 2015-08-27
JP6498212B2 (ja) 2019-04-10
JP2017506250A (ja) 2017-03-02
US9932344B2 (en) 2018-04-03
NZ724323A (en) 2022-02-25
SMT201900266T1 (it) 2019-07-11

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