AU2015220560B2 - Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use - Google Patents
Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use Download PDFInfo
- Publication number
- AU2015220560B2 AU2015220560B2 AU2015220560A AU2015220560A AU2015220560B2 AU 2015220560 B2 AU2015220560 B2 AU 2015220560B2 AU 2015220560 A AU2015220560 A AU 2015220560A AU 2015220560 A AU2015220560 A AU 2015220560A AU 2015220560 B2 AU2015220560 B2 AU 2015220560B2
- Authority
- AU
- Australia
- Prior art keywords
- compound according
- independently
- cdk
- ppda
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CN(CC1)CCN1c1ccc(**)cc1 Chemical compound CN(CC1)CCN1c1ccc(**)cc1 0.000 description 10
- HNVBBNZWMSTMAZ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(C)=O)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(C)=O)=O HNVBBNZWMSTMAZ-UHFFFAOYSA-N 0.000 description 1
- JNKLYQCECQNLQD-KNIDRKIYSA-N CC(C)c(cn[n]1c(NC(CC2)CCN2S(c(cc2)cc(C(C[C@@H]3CNc4nc5c(C(C)C)cn[n]5c(Nc(cc5)ccc5S(N(C)C)(=O)=O)c4)NC[C@@H]3O)c2F)(=O)=O)c2)c1nc2NC[C@@H](CCN(C1)C(C2)N(C)CCN2c(cc2)ccc2Nc2cc(NC[C@@H](CCNC3)[C@H]3O)nc3c(C(C)C)cn[n]23)[C@H]1O Chemical compound CC(C)c(cn[n]1c(NC(CC2)CCN2S(c(cc2)cc(C(C[C@@H]3CNc4nc5c(C(C)C)cn[n]5c(Nc(cc5)ccc5S(N(C)C)(=O)=O)c4)NC[C@@H]3O)c2F)(=O)=O)c2)c1nc2NC[C@@H](CCN(C1)C(C2)N(C)CCN2c(cc2)ccc2Nc2cc(NC[C@@H](CCNC3)[C@H]3O)nc3c(C(C)C)cn[n]23)[C@H]1O JNKLYQCECQNLQD-KNIDRKIYSA-N 0.000 description 1
- DPLYAMCNFUJBLH-UHFFFAOYSA-N CC(C)c(cn[n]1c(NCc2ccccc2)c2)c1nc2Cl Chemical compound CC(C)c(cn[n]1c(NCc2ccccc2)c2)c1nc2Cl DPLYAMCNFUJBLH-UHFFFAOYSA-N 0.000 description 1
- AUZGEDPWRMYCLE-JOCHJYFZSA-N CC(C)c(cn[n]1c(NCc2ccccc2)c2)c1nc2NC[C@]1(CO)CNCC1 Chemical compound CC(C)c(cn[n]1c(NCc2ccccc2)c2)c1nc2NC[C@]1(CO)CNCC1 AUZGEDPWRMYCLE-JOCHJYFZSA-N 0.000 description 1
- LLEXBMZDQFJISK-XXBNENTESA-N CC(C)c(cn[n]1c(Nc(cc2)ccc2N2CCN(C)CC2)c2)c1nc2NC[C@@H](CCNC1)[C@H]1O Chemical compound CC(C)c(cn[n]1c(Nc(cc2)ccc2N2CCN(C)CC2)c2)c1nc2NC[C@@H](CCNC1)[C@H]1O LLEXBMZDQFJISK-XXBNENTESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201403093A GB201403093D0 (en) | 2014-02-21 | 2014-02-21 | Therapeutic compounds and their use |
| GB1403093.6 | 2014-02-21 | ||
| PCT/GB2015/050494 WO2015124941A1 (en) | 2014-02-21 | 2015-02-20 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as cdk inhibitors and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015220560A1 AU2015220560A1 (en) | 2016-10-06 |
| AU2015220560B2 true AU2015220560B2 (en) | 2019-05-16 |
Family
ID=50482596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015220560A Active AU2015220560B2 (en) | 2014-02-21 | 2015-02-20 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9932344B2 (enExample) |
| EP (1) | EP3107914B8 (enExample) |
| JP (1) | JP6498212B2 (enExample) |
| CN (1) | CN106103445B (enExample) |
| AU (1) | AU2015220560B2 (enExample) |
| BR (1) | BR112016018633B1 (enExample) |
| CA (1) | CA2939786C (enExample) |
| CY (1) | CY1121588T1 (enExample) |
| DK (1) | DK3107914T3 (enExample) |
| ES (1) | ES2721268T3 (enExample) |
| GB (1) | GB201403093D0 (enExample) |
| HR (1) | HRP20190685T1 (enExample) |
| HU (1) | HUE043122T2 (enExample) |
| LT (1) | LT3107914T (enExample) |
| ME (1) | ME03427B (enExample) |
| NZ (1) | NZ724323A (enExample) |
| PL (1) | PL3107914T3 (enExample) |
| PT (1) | PT3107914T (enExample) |
| RS (1) | RS58704B1 (enExample) |
| SI (1) | SI3107914T1 (enExample) |
| SM (1) | SMT201900266T1 (enExample) |
| TR (1) | TR201905647T4 (enExample) |
| WO (1) | WO2015124941A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US10131679B2 (en) | 2014-10-31 | 2018-11-20 | Ube Industries, Ltd. | Substituted dihydropyrrolopyrazole compound |
| WO2016097004A1 (en) | 2014-12-17 | 2016-06-23 | King's College London | BICYCLOHETEROARYL-HETEROARYL-BENZOIC ACID COMPOUNDS AS RETINOIC ACID RECEPTOR BETA (RARβ) AGONISTS |
| CN113563342A (zh) * | 2015-02-13 | 2021-10-29 | 达纳－法伯癌症研究所公司 | Lrrk2抑制剂及其制备和使用方法 |
| RU2765718C1 (ru) | 2015-06-15 | 2022-02-02 | Убе Индастриз, Лтд. | Замещенное производное дигидропирролопиразола |
| US20200123499A1 (en) | 2015-12-02 | 2020-04-23 | Massachusetts Institute Of Technology | Method for efficient generation of neurons from non-neuronal cells |
| MA46092A (fr) | 2016-08-31 | 2021-04-21 | Agios Pharmaceuticals Inc | Inhibiteurs de processus métaboliques cellulaires |
| WO2019023468A1 (en) | 2017-07-28 | 2019-01-31 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
| MX2020001531A (es) * | 2017-08-07 | 2020-03-20 | Biocad Joint Stock Co | Nuevos compuestos hetorociclicos como inhibidores de cdk8/19. |
| WO2019035866A1 (en) * | 2017-08-15 | 2019-02-21 | The Brigham & Women's Hospital, Inc. | COMPOSITIONS AND METHODS FOR TREATING THE TUBEROUS SCLEROSIS COMPLEX |
| GB201715194D0 (en) | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
| TWI703149B (zh) * | 2017-11-16 | 2020-09-01 | 美商美國禮來大藥廠 | 用於抑制cdk7之化合物 |
| IL277770B2 (en) * | 2018-04-11 | 2024-01-01 | Qurient Co Ltd | Pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives as selective inhibitor of cyclin dependent kinase |
| WO2019213403A1 (en) | 2018-05-02 | 2019-11-07 | Kinnate Biopharma Inc. | Inhibitors of cyclin-dependent kinases |
| BR112020026748A2 (pt) | 2018-06-29 | 2021-03-30 | Kinnate Biopharma Inc. | Inibidores de quinases dependentes de ciclina |
| PE20212196A1 (es) * | 2018-10-30 | 2021-11-16 | Kronos Bio Inc | Compuestos, composiciones, y metodos para modular la actividad cdk9 |
| EP3885347B1 (en) | 2018-11-14 | 2023-11-22 | UBE Corporation | Dihydropyrrolopyrazole derivative |
| CN109860354B (zh) * | 2018-12-28 | 2020-05-19 | 南京邮电大学 | 同质集成红外光子芯片及其制备方法 |
| US20220144841A1 (en) * | 2019-03-13 | 2022-05-12 | The Translational Genomics Research Institute | Trisubstituted pyrazolo [1,5-a] pyrimidine compounds as cdk7 inhibitors |
| WO2021003517A1 (en) * | 2019-07-10 | 2021-01-14 | Aucentra Therapeutics Pty Ltd | Derivatives of 4-(imidazo[l,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin- 2-amine as therapeutic agents |
| IL292519A (en) * | 2019-10-29 | 2022-06-01 | Syros Pharmaceuticals Inc | Methods for treating cancer in patients identified with a biomarker with cyclin-dependent kinase 7 (cdk7) inhibitors |
| GB201918541D0 (en) * | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| WO2021176045A1 (en) * | 2020-03-06 | 2021-09-10 | Bayer Aktiengesellschaft | Imidazotriazines acting on cancer via inhibition of cdk12 |
| US20230158159A1 (en) * | 2020-04-24 | 2023-05-25 | Massachusetts Institute Of Technology | Chimeric degraders of cyclin-dependent kinase 9 and uses thereof |
| CA3206043A1 (en) * | 2021-01-22 | 2022-07-28 | Zhiming Zhao | Substituted pyrazolo[1,5-a]pyrimidin-7-amine derivative, composition and pharmaceutical use thereof |
| TW202309030A (zh) | 2021-05-07 | 2023-03-01 | 美商凱麥拉醫療公司 | Cdk2降解劑及其用途 |
| GB202108572D0 (en) * | 2021-06-16 | 2021-07-28 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| WO2023001061A1 (en) * | 2021-07-17 | 2023-01-26 | Jingrui Biopharma Co., Ltd. | Cdk7 selective inhibitors as anticancer agents |
| US20250059193A1 (en) * | 2021-11-24 | 2025-02-20 | Kronos Bio, Inc. | Polymorphic and salt forms of (1s,3s)-n1-(5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl) cyclopentane-1,3-diamine |
| WO2024102447A1 (en) * | 2022-11-10 | 2024-05-16 | Emory University | Uses of hydroimidazopyridopyrimidinone derivatives for managing aneurysms or other vascular conditions or diseases |
| WO2024174949A1 (zh) * | 2023-02-20 | 2024-08-29 | 江苏正大丰海制药有限公司 | 作为cdk7激酶抑制剂的杂芳环化合物及其制备和应用 |
| CN120712267A (zh) * | 2023-02-21 | 2025-09-26 | 杭州德睿智药科技有限公司 | 作为CDKs抑制剂的新型并杂环类新化合物及其应用 |
| WO2025006569A1 (en) | 2023-06-27 | 2025-01-02 | Arvinas Operations, Inc. | Combinations of estrogen receptor degraders and cdk7 inhibitors for the treatment of cancer |
| WO2025057087A1 (en) | 2023-09-11 | 2025-03-20 | Assia Chemical Industries Ltd. | Solid state forms of samuraciclib |
| WO2025208097A1 (en) * | 2024-03-29 | 2025-10-02 | The Translational Genomics Research Institute | Cdk7 inhibitors and methods of use thereof |
| WO2025208104A1 (en) * | 2024-03-29 | 2025-10-02 | The Translational Genomics Research Institute | Cdk7 inhibitors and methods of use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004087707A1 (en) * | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003519143A (ja) | 1999-12-28 | 2003-06-17 | ファーマコピーア，インコーポレーティッド | ピリミジン及びトリアジン系キナーゼ阻害剤 |
| DK1537116T3 (da) | 2002-09-04 | 2010-09-27 | Schering Corp | Pyrazolopyrimidiner egnede til behandling af cancersygdomme |
| CA2513684A1 (en) | 2003-01-31 | 2004-08-19 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| KR20050115252A (ko) | 2003-02-28 | 2005-12-07 | 데이진 화-마 가부시키가이샤 | 피라졸로[1,5-ａ]피리미딘 유도체 |
| JO2478B1 (en) | 2003-06-19 | 2009-01-20 | جانسين فارماسوتيكا ان. في. | (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists |
| US20070082900A1 (en) * | 2005-10-06 | 2007-04-12 | Schering Corporation | Methods for inhibiting protein kinases |
| WO2008151304A1 (en) * | 2007-06-05 | 2008-12-11 | Emory University | Selective inhibitors for cyclin-dependent kinases |
| PL2509602T3 (pl) * | 2009-12-04 | 2017-08-31 | Senhwa Biosciences, Inc. | Pirazolopirymidyny i podobne heterocykle jako inhibitory ck2 |
| WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
| ES2671748T3 (es) * | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
| EP2634190A1 (en) | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| EP2634189A1 (en) | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors |
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
-
2014
- 2014-02-21 GB GB201403093A patent/GB201403093D0/en not_active Ceased
-
2015
- 2015-02-20 NZ NZ724323A patent/NZ724323A/en unknown
- 2015-02-20 ES ES15706282T patent/ES2721268T3/es active Active
- 2015-02-20 ME MEP-2019-119A patent/ME03427B/me unknown
- 2015-02-20 US US15/117,982 patent/US9932344B2/en active Active
- 2015-02-20 RS RS20190487A patent/RS58704B1/sr unknown
- 2015-02-20 SI SI201530714T patent/SI3107914T1/sl unknown
- 2015-02-20 SM SM20190266T patent/SMT201900266T1/it unknown
- 2015-02-20 JP JP2016553387A patent/JP6498212B2/ja active Active
- 2015-02-20 PT PT15706282T patent/PT3107914T/pt unknown
- 2015-02-20 WO PCT/GB2015/050494 patent/WO2015124941A1/en not_active Ceased
- 2015-02-20 CN CN201580011502.7A patent/CN106103445B/zh active Active
- 2015-02-20 TR TR2019/05647T patent/TR201905647T4/tr unknown
- 2015-02-20 HR HRP20190685TT patent/HRP20190685T1/hr unknown
- 2015-02-20 AU AU2015220560A patent/AU2015220560B2/en active Active
- 2015-02-20 HU HUE15706282A patent/HUE043122T2/hu unknown
- 2015-02-20 DK DK15706282.9T patent/DK3107914T3/en active
- 2015-02-20 LT LTEP15706282.9T patent/LT3107914T/lt unknown
- 2015-02-20 CA CA2939786A patent/CA2939786C/en active Active
- 2015-02-20 BR BR112016018633-8A patent/BR112016018633B1/pt active IP Right Grant
- 2015-02-20 PL PL15706282T patent/PL3107914T3/pl unknown
- 2015-02-20 EP EP15706282.9A patent/EP3107914B8/en active Active
-
2018
- 2018-03-30 US US15/941,063 patent/US10414772B2/en active Active
-
2019
- 2019-04-17 CY CY20191100425T patent/CY1121588T1/el unknown
- 2019-09-04 US US16/559,735 patent/US10927119B2/en active Active
-
2021
- 2021-02-15 US US17/175,780 patent/US11566029B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004087707A1 (en) * | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
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Legal Events
| Date | Code | Title | Description |
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| HB | Alteration of name in register |
Owner name: EMORY UNIVERSITY Free format text: FORMER NAME(S): CANCER RESEARCH TECHNOLOGY LIMITED; EMORY UNIVERSITY; IMPERIAL INNOVATIONS LIMITED Owner name: CANCER RESEARCH TECHNOLOGY LIMITED Free format text: FORMER NAME(S): CANCER RESEARCH TECHNOLOGY LIMITED; EMORY UNIVERSITY; IMPERIAL INNOVATIONS LIMITED Owner name: IP2IPO INNOVATIONS LIMITED Free format text: FORMER NAME(S): CANCER RESEARCH TECHNOLOGY LIMITED; EMORY UNIVERSITY; IMPERIAL INNOVATIONS LIMITED |
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| FGA | Letters patent sealed or granted (standard patent) |