AR115646A1 - Inhibidores de quinasas dependientes de ciclinas - Google Patents
Inhibidores de quinasas dependientes de ciclinasInfo
- Publication number
- AR115646A1 AR115646A1 ARP190101813A ARP190101813A AR115646A1 AR 115646 A1 AR115646 A1 AR 115646A1 AR P190101813 A ARP190101813 A AR P190101813A AR P190101813 A ARP190101813 A AR P190101813A AR 115646 A1 AR115646 A1 AR 115646A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- cycloalkyl
- hydrogen
- so2n
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Inhibidores de quinasas dependientes de ciclinas (CDK), composiciones farmacéuticas que comprenden dichos compuestos y métodos para su utilización en el tratamiento de enfermedades. Reivindicación 1: Un compuesto, o una sal farmacéuticamente aceptable o solvato del mismo, que tiene la estructura de la fórmula (1) donde, E se selecciona entre un enlace, -SO₂-, -C(O)-, -CH₂-, -CH(R⁴)-, o -C(R⁴)₂-; G se selecciona entre los grupos que tienen la estructura del grupo de fórmulas (2) donde, L es O, NH, N(C₁₋₄ alquilo opcionalmente sustituido), o -NH-CH₂-* donde el * denota el punto de unión al anillo fenilo; t es 0, 1, ó 2; u es 1, ó 2; p es 0, 1, ó 2; r es 0, 1, ó 2; R¹ se selecciona entre hidrógeno, C₁₋₄ alquilo opcionalmente sustituido, o heterociclilalquilo opcionalmente sustituido; R² se selecciona entre hidrógeno, o C₁₋₄ alquilo opcionalmente sustituido, R³ se selecciona entre hidrógeno, -CN, o C₁₋₄ alquilo opcionalmente sustituido; cada R⁴ se selecciona de manera independiente entre C₁₋₄ alquilo opcionalmente sustituido, o heterociclilalquilo opcionalmente sustituido; R⁵ puede ser C₁₋₄ alquilo opcionalmente sustituido, o heterociclilalquilo opcionalmente sustituido; cada R¹¹ es, de manera independiente hidrógeno, halógeno, C₁₋₆ alquilo opcionalmente sustituido, -OH, C₁₋₄ alcoxi opcionalmente sustituido, o dos grupos R¹¹ sobre el mismo átomo de carbono forman un oxo; R¹² es hidrógeno o C₁₋₄ alquilo opcionalmente sustituido; q es 0, 1, 2, ó 3; n es 0, 1, 2, ó 3; m es 0, 1, 2, ó 3; cada X es, de manera independiente halógeno, C₁₋₄ alquilo opcionalmente sustituido, C₁₋₄ alcoxi opcionalmente sustituido, aminoalquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterociclo opcionalmente sustituido, arilo opcionalmente sustituido, o heteroarilo opcionalmente sustituido; Y es un grupo que se selecciona entre los restos del grupo de fórmulas (3) donde, R¹⁵ se selecciona entre hidrógeno, halógeno, -CN, alquilo opcionalmente sustituido, fluoroalquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterociclo opcionalmente sustituido, cicloalquilalquilo opcionalmente sustituido, cicloalquil-O-opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, ariloxi opcionalmente sustituido, aralquiloxi opcionalmente sustituido, heteroariloxi opcionalmente sustituido, heteroaralquiloxi opcionalmente sustituido, -OR²², -N(R²²)₂, -SO₂R²¹, -N(R²²)SO₂R²¹, -SO₂N(R²²)₂, -N(R²²)SO₂N(R²²)₂, -CON(R²²)₂, -N(R²²)CO₂R²¹, -N(R²²)CON(R²²)₂, -N(R²²)COR²¹, -OC(O)N(R²²)₂, -OSO₂N(R²²)₂, o -N(R²²)SO₃R²¹; R¹⁶ se selecciona entre hidrógeno, halógeno, -CN, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, fluoroalquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterociclo opcionalmente sustituido, cicloalquilalquilo opcionalmente sustituido, cicloalquil-O-opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroaralquilo opcionalmente sustituido, ariloxi opcionalmente sustituido, aralquiloxi opcionalmente sustituido, heteroariloxi opcionalmente sustituido, heteroaralquiloxi opcionalmente sustituido, -OR²², -N(R²²)₂, -SO₂R²¹, -N(R²²)SO₂R²¹, -SO₂N(R²²)₂, -N(R²²)SO₂N(R²²)₂, -CON(R²²)₂, -N(R²²)CO₂R²¹, -N(R²²)CON(R²²)₂, -N(R²²)COR²¹, -OC(O)N(R²²)₂, -OSO₂N(R²²)₂, o -N(R²²)SO₃R²¹; R¹⁷ se selecciona entre hidrógeno, halógeno, -CN, alquilo opcionalmente sustituido, fluoroalquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterociclo opcionalmente sustituido, cicloalquilalquilo opcionalmente sustituido, cicloalquil-O-opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, ariloxi opcionalmente sustituido, aralquiloxi opcionalmente sustituido, heteroariloxi opcionalmente sustituido, heteroaralquiloxi opcionalmente sustituido, -OR²², -N(R²²)₂, -SO₂R²¹, -N(R²²)SO₂R²¹, -SO₂N(R²²)₂, -N(R²²)SO₂N(R²²)₂, -CON(R²²)₂, -N(R²²)CO₂R²¹, -N(R²²)CON(R²²)₂, -N(R²²)COR²¹, -OC(O)N(R²²)₂, -OSO₂N(R²²)₂, o -N(R²²)SO₃R²¹; R¹⁸ se selecciona entre hidrógeno, halógeno, -CN, alquilo opcionalmente sustituido, fluoroalquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, cicloalquilo opcionalmente sustituido, heterociclo opcionalmente sustituido, cicloalquilalquilo opcionalmente sustituido, cicloalquil-O-opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroaralquilo opcionalmente sustituido, ariloxi opcionalmente sustituido, aralquiloxi opcionalmente sustituido, heteroariloxi opcionalmente sustituido, heteroaralquiloxi opcionalmente sustituido, -OR²², -N(R²²)₂, -SO₂R²¹, -N(R²²)SO₂R²¹, -SO₂N(R²²)₂, -N(R²²)SO₂N(R²²)₂, -CON(R²²)₂, -N(R²²)CO₂R²¹, -N(R²²)CON(R²²)₂, -N(R²²)COR²¹, -OC(O)N(R²²)₂, -OSO₂N(R²²)₂, o -N(R²²)SO₃R²¹; cada R²¹ se selecciona de manera independiente entre alquilo, cicloalquilo, cicloalquilalquilo, arilo, aralquilo, heterociclilo, heterociclilalquilo, heteroarilo, o heteroarilalquilo; y cada R²² se selecciona de manera independiente entre hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, arilo, aralquilo, heterociclilo, heterociclilalquilo, heteroarilo, o heteroarilalquilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862691879P | 2018-06-29 | 2018-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115646A1 true AR115646A1 (es) | 2021-02-10 |
Family
ID=68985220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190101813A AR115646A1 (es) | 2018-06-29 | 2019-06-28 | Inhibidores de quinasas dependientes de ciclinas |
Country Status (14)
Country | Link |
---|---|
US (2) | US10894788B2 (es) |
EP (1) | EP3813819A4 (es) |
JP (1) | JP2021529740A (es) |
KR (1) | KR20210040368A (es) |
CN (1) | CN112638373A (es) |
AR (1) | AR115646A1 (es) |
AU (1) | AU2019291935A1 (es) |
BR (1) | BR112020026748A2 (es) |
CA (1) | CA3104131A1 (es) |
IL (1) | IL279791A (es) |
MX (1) | MX2020014245A (es) |
SG (1) | SG11202013175SA (es) |
TW (1) | TW202016094A (es) |
WO (1) | WO2020006497A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11447493B2 (en) | 2018-05-02 | 2022-09-20 | Kinnate Biopharma Inc. | Inhibitors of cyclin-dependent kinases |
CN112638373A (zh) | 2018-06-29 | 2021-04-09 | 金耐特生物制药公司 | 细胞周期蛋白依赖性激酶抑制剂 |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
WO2020180959A1 (en) * | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
AU2020315640A1 (en) * | 2019-07-17 | 2022-03-03 | Kinnate Biopharma Inc. | Inhibitors of cyclin-dependent kinases |
AR119765A1 (es) | 2019-08-14 | 2022-01-12 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 |
MX2022004390A (es) | 2019-10-11 | 2022-08-08 | Incyte Corp | Aminas biciclicas como inhibidores de la cinasa dependiente de ciclina 2 (cdk2). |
CA3166386A1 (en) * | 2019-12-31 | 2021-07-08 | Kinnate Biopharma Inc. | Treatment of cancer with cdk12/13 inhibitors |
US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
EP4387965A2 (en) | 2021-08-18 | 2024-06-26 | ChemoCentryx, Inc. | Aryl sulfonyl compounds as ccr6 inhibitors |
CA3228553A1 (en) | 2021-08-18 | 2023-02-23 | Chemocentryx, Inc. | Aryl sulfonyl (hydroxy) piperidines as ccr6 inhibitors |
TW202329937A (zh) * | 2021-12-03 | 2023-08-01 | 美商英塞特公司 | 雙環胺ck12抑制劑 |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
WO2024032561A1 (en) * | 2022-08-08 | 2024-02-15 | Insilico Medicine Ip Limited | Inhibitors of cyclin-dependent kinase (cdk) 12 and/or cdk13 and uses thereof |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW249201B (es) * | 1992-07-02 | 1995-06-11 | Otsuka Pharma Co Ltd | |
US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
KR100477070B1 (ko) | 1994-03-25 | 2006-04-21 | 이소테크니카 인코포레이티드 | 중수소화작용에의한의약품의효능강화법 |
US20070004763A1 (en) | 2005-06-10 | 2007-01-04 | Nand Baindur | Aminoquinoline and aminoquinazoline kinase modulators |
BR112014002675A2 (pt) | 2011-08-04 | 2017-02-21 | Array Biopharma Inc | "quinazolina como inibidores de serina/treonina quinase, seus usos, e composição" |
US20140309184A1 (en) | 2011-09-21 | 2014-10-16 | University Of South Alabama | Methods and compositions for the treatment of ovarian cancer |
AU2012340200B2 (en) | 2011-11-17 | 2017-10-12 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-Terminal Kinase (JNK) |
EP3057954A2 (en) * | 2013-10-18 | 2016-08-24 | Syros Pharmaceuticals, Inc. | Heteromaromatic compounds useful for the treatment of proliferative diseases |
ES2676734T3 (es) | 2013-10-18 | 2018-07-24 | Syros Pharmaceuticals, Inc. | Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas |
GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
WO2016073420A1 (en) * | 2014-11-05 | 2016-05-12 | Dart Neuroscience, Llc | Substituted azetidinyl compounds as glyt1 inhibitors |
EP3236959A4 (en) | 2014-12-23 | 2018-04-25 | Dana Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
CA2978518C (en) * | 2015-03-27 | 2023-11-21 | Nathanael S. Gray | Inhibitors of cyclin-dependent kinases |
WO2016193939A1 (en) | 2015-06-04 | 2016-12-08 | Aurigene Discovery Technologies Limited | Substituted heterocyclyl derivatives as cdk inhibitors |
AU2016276963C1 (en) * | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CA2988330A1 (en) * | 2015-06-26 | 2016-12-29 | Dana-Farber Cancer Institute, Inc. | 4,6-pyrimidinylene derivatives and uses thereof |
CA2996978A1 (en) | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
GB201605126D0 (en) | 2016-03-24 | 2016-05-11 | Univ Nottingham | Inhibitors and their uses |
AU2017363307B2 (en) * | 2016-11-22 | 2021-07-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 12 (CDK12) and uses thereof |
KR20190092476A (ko) * | 2016-12-19 | 2019-08-07 | 이소큐어 바이오사이언스 인코퍼레이티드 | 돌연변이체 이소시트레이트 탈수소효소 억제제 및 그 조성물 및 그 제조방법 |
WO2019035866A1 (en) * | 2017-08-15 | 2019-02-21 | The Brigham & Women's Hospital, Inc. | COMPOSITIONS AND METHODS FOR TREATING THE TUBEROUS SCLEROSIS COMPLEX |
GB201715342D0 (en) | 2017-09-22 | 2017-11-08 | Univ Nottingham | Compounds |
US11447493B2 (en) | 2018-05-02 | 2022-09-20 | Kinnate Biopharma Inc. | Inhibitors of cyclin-dependent kinases |
CN112638373A (zh) | 2018-06-29 | 2021-04-09 | 金耐特生物制药公司 | 细胞周期蛋白依赖性激酶抑制剂 |
AU2020315640A1 (en) | 2019-07-17 | 2022-03-03 | Kinnate Biopharma Inc. | Inhibitors of cyclin-dependent kinases |
CA3166386A1 (en) | 2019-12-31 | 2021-07-08 | Kinnate Biopharma Inc. | Treatment of cancer with cdk12/13 inhibitors |
-
2019
- 2019-06-28 CN CN201980057125.9A patent/CN112638373A/zh active Pending
- 2019-06-28 EP EP19825341.1A patent/EP3813819A4/en active Pending
- 2019-06-28 CA CA3104131A patent/CA3104131A1/en active Pending
- 2019-06-28 US US16/457,400 patent/US10894788B2/en active Active
- 2019-06-28 MX MX2020014245A patent/MX2020014245A/es unknown
- 2019-06-28 TW TW108122977A patent/TW202016094A/zh unknown
- 2019-06-28 AU AU2019291935A patent/AU2019291935A1/en active Pending
- 2019-06-28 JP JP2020571485A patent/JP2021529740A/ja active Pending
- 2019-06-28 AR ARP190101813A patent/AR115646A1/es unknown
- 2019-06-28 SG SG11202013175SA patent/SG11202013175SA/en unknown
- 2019-06-28 WO PCT/US2019/039959 patent/WO2020006497A1/en active Application Filing
- 2019-06-28 BR BR112020026748-1A patent/BR112020026748A2/pt not_active Application Discontinuation
- 2019-06-28 KR KR1020217002677A patent/KR20210040368A/ko active Search and Examination
-
2020
- 2020-11-11 US US17/095,672 patent/US11390618B2/en active Active
- 2020-12-27 IL IL279791A patent/IL279791A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3104131A1 (en) | 2020-01-02 |
US20200024266A1 (en) | 2020-01-23 |
MX2020014245A (es) | 2021-05-12 |
IL279791A (en) | 2021-03-01 |
WO2020006497A1 (en) | 2020-01-02 |
AU2019291935A1 (en) | 2021-02-04 |
US20210130340A1 (en) | 2021-05-06 |
SG11202013175SA (en) | 2021-01-28 |
EP3813819A1 (en) | 2021-05-05 |
EP3813819A4 (en) | 2022-08-17 |
CN112638373A (zh) | 2021-04-09 |
BR112020026748A2 (pt) | 2021-03-30 |
JP2021529740A (ja) | 2021-11-04 |
TW202016094A (zh) | 2020-05-01 |
US10894788B2 (en) | 2021-01-19 |
US11390618B2 (en) | 2022-07-19 |
KR20210040368A (ko) | 2021-04-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR115646A1 (es) | Inhibidores de quinasas dependientes de ciclinas | |
AR103252A1 (es) | Compuestos de quinazolina | |
AR114044A1 (es) | Composiciones y métodos para el tratamiento de trastornos en el sistema nervioso central | |
AR107488A1 (es) | Compuestos de benzopirazol y análogos de éstos | |
AR103297A1 (es) | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina | |
AR119698A2 (es) | Compuesto amida n-urea sustituida derivado de aminoácido | |
AR104025A1 (es) | Carbamatos de piperazina como moduladores de magl y/o abhd6, procesos para su preparación y composiciones farmacéuticas | |
AR101692A1 (es) | Compuestos y métodos para inhibir histonas demetilasas | |
AR087760A1 (es) | Heterociclilaminas como inhibidores de pi3k | |
AR103574A1 (es) | Compuestos tricíclicos y usos de lo mismos en medicina | |
AR112216A1 (es) | Derivados de azaquinolina | |
AR091193A1 (es) | HETEROCICLOS DE 5 MIEMBROS QUE CONTIENEN NITROGENO SUSTITUIDO POR CARBOXAMIDA O SULFONAMIDA COMO MODULADORES PARA EL RECEPTOR NUCLEAR HUERFANO RORg | |
AR115092A1 (es) | Inhibidores de magl | |
AR111407A1 (es) | Compuestos inhibidores de ask1 y usos de los mismos | |
AR093518A1 (es) | Compuestos de pirrolpirimidina como inhibidores de quinasas | |
AR096837A1 (es) | Heterociclos tricíclicos como inhibidores de proteínas bet | |
AR105575A1 (es) | COMPUESTOS DE QUINOLINA COMO MODULADORES DE TNFa | |
AR089143A1 (es) | Triazolopiridinas sustituidas con actividad inhibidora de ttk | |
AR116114A1 (es) | Amidas heterocíclicas de entre 5 y 7 miembros como inhibidores de jak | |
AR098776A1 (es) | Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas | |
AR089113A1 (es) | Inhibidores de quinasa | |
AR096332A1 (es) | Compuestos heterocíclicos tricíclicos condensados como inhibidores de la integrasa del vih | |
AR118826A1 (es) | Inhibidores de cinasas raf | |
AR094496A1 (es) | Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas | |
AR109650A1 (es) | Compuestos de heteroarilcarboxamida como inhibidores de ripk2 |