CN106103412B - 通过2,2-二氟乙胺的烷基化制备n-[(6-氯吡啶-3-基)甲基]-2,2-二氟乙-1-胺的方法 - Google Patents
通过2,2-二氟乙胺的烷基化制备n-[(6-氯吡啶-3-基)甲基]-2,2-二氟乙-1-胺的方法 Download PDFInfo
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- CN106103412B CN106103412B CN201580015173.3A CN201580015173A CN106103412B CN 106103412 B CN106103412 B CN 106103412B CN 201580015173 A CN201580015173 A CN 201580015173A CN 106103412 B CN106103412 B CN 106103412B
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- amine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0255—Phosphorus containing compounds
- B01J31/0267—Phosphines or phosphonium compounds, i.e. phosphorus bonded to at least one carbon atom, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, the other atoms bonded to phosphorus being either carbon or hydrogen
- B01J31/0268—Phosphonium compounds, i.e. phosphine with an additional hydrogen or carbon atom bonded to phosphorous so as to result in a formal positive charge on phosphorous
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14161110.3 | 2014-03-21 | ||
| EP14161110 | 2014-03-21 | ||
| PCT/EP2015/055639 WO2015140198A1 (de) | 2014-03-21 | 2015-03-18 | Verfahren zur herstellung von n-[(6-chlorpyridin-3-yl)methyl]-2,2-difluorethan-1-amin durch alkylierung von 2,2-difluorethylamin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106103412A CN106103412A (zh) | 2016-11-09 |
| CN106103412B true CN106103412B (zh) | 2019-03-19 |
Family
ID=50336216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580015173.3A Active CN106103412B (zh) | 2014-03-21 | 2015-03-18 | 通过2,2-二氟乙胺的烷基化制备n-[(6-氯吡啶-3-基)甲基]-2,2-二氟乙-1-胺的方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9890120B2 (enExample) |
| EP (1) | EP3119747B1 (enExample) |
| JP (1) | JP6533233B2 (enExample) |
| KR (1) | KR102360975B1 (enExample) |
| CN (1) | CN106103412B (enExample) |
| BR (1) | BR112016021564B1 (enExample) |
| DK (1) | DK3119747T3 (enExample) |
| ES (1) | ES2699927T3 (enExample) |
| IL (1) | IL247751B (enExample) |
| MX (1) | MX381217B (enExample) |
| TW (1) | TWI648263B (enExample) |
| WO (1) | WO2015140198A1 (enExample) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102336747A (zh) * | 2006-03-31 | 2012-02-01 | 拜尔农作物科学股份公司 | 被取代的烯氨羰基化合物 |
| CN103313969A (zh) * | 2010-11-12 | 2013-09-18 | 拜耳知识产权有限责任公司 | 用于由n-(2，2-二氟乙基)丙-2-烯-1-胺起始制备2，2-二氟乙基胺衍生物的方法 |
| WO2014001245A1 (de) * | 2012-06-29 | 2014-01-03 | Bayer Cropscience Ag | Verfahren zur herstellung von 2,2-difluorethylamin-derivaten durch alkylierung von 2,2-difluorethylamin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006033572A1 (de) * | 2006-07-20 | 2008-01-24 | Bayer Cropscience Ag | N'-Cyano-N-halogenalkyl-imidamid Derivate |
| WO2009036900A1 (de) | 2007-09-18 | 2009-03-26 | Bayer Cropscience Ag | Verfahren zur herstellung von 2,2-difluorethylamin-derivaten durch amid-hydrierung |
| EP2039678A1 (de) * | 2007-09-18 | 2009-03-25 | Bayer CropScience AG | Verfahren zum Herstellen von 4-Aminobut-2-enoliden |
| EP2039684A1 (de) | 2007-09-18 | 2009-03-25 | Bayer CropScience AG | Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung |
| EP2264008A1 (de) * | 2009-06-18 | 2010-12-22 | Bayer CropScience AG | Substituierte Enaminocarbonylverbindungen |
| MX2012014578A (es) * | 2010-06-15 | 2013-02-07 | Bayer Ip Gmbh | Procedimiento para preparar derivados de 2, 2-difluoroetilamina mediante alquilacion con 2, 2-difluoroetil-1-haloetanos. |
| CN103242225B (zh) * | 2012-02-13 | 2016-01-06 | 湖南化工研究院 | 吡啶甲胺基吡啶类化合物及其制备方法 |
-
2015
- 2015-03-18 KR KR1020167029182A patent/KR102360975B1/ko active Active
- 2015-03-18 EP EP15710775.6A patent/EP3119747B1/de active Active
- 2015-03-18 DK DK15710775.6T patent/DK3119747T3/da active
- 2015-03-18 CN CN201580015173.3A patent/CN106103412B/zh active Active
- 2015-03-18 WO PCT/EP2015/055639 patent/WO2015140198A1/de not_active Ceased
- 2015-03-18 US US15/126,593 patent/US9890120B2/en active Active
- 2015-03-18 MX MX2016012057A patent/MX381217B/es unknown
- 2015-03-18 ES ES15710775T patent/ES2699927T3/es active Active
- 2015-03-18 JP JP2016557945A patent/JP6533233B2/ja active Active
- 2015-03-18 BR BR112016021564-8A patent/BR112016021564B1/pt active IP Right Grant
- 2015-03-19 TW TW104108720A patent/TWI648263B/zh active
-
2016
- 2016-09-11 IL IL247751A patent/IL247751B/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102336747A (zh) * | 2006-03-31 | 2012-02-01 | 拜尔农作物科学股份公司 | 被取代的烯氨羰基化合物 |
| CN103313969A (zh) * | 2010-11-12 | 2013-09-18 | 拜耳知识产权有限责任公司 | 用于由n-(2，2-二氟乙基)丙-2-烯-1-胺起始制备2，2-二氟乙基胺衍生物的方法 |
| WO2014001245A1 (de) * | 2012-06-29 | 2014-01-03 | Bayer Cropscience Ag | Verfahren zur herstellung von 2,2-difluorethylamin-derivaten durch alkylierung von 2,2-difluorethylamin |
Non-Patent Citations (1)
| Title |
|---|
| Nanjing Zhang，等.Structural Features of Azidopyridinyl Neonicotinoid Probes Conferring High Affinity and Selectivity for Mammalian r4â2 and Drosophila Nicotinic Receptors.《J. Med. Chem.》.2002,第45卷(第13期),第2832-2840页，尤其参见2834页Scheme3. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017507989A (ja) | 2017-03-23 |
| EP3119747B1 (de) | 2018-08-29 |
| EP3119747A1 (de) | 2017-01-25 |
| JP6533233B2 (ja) | 2019-06-19 |
| CN106103412A (zh) | 2016-11-09 |
| BR112016021564A2 (pt) | 2017-10-03 |
| US20170081284A1 (en) | 2017-03-23 |
| MX2016012057A (es) | 2017-01-19 |
| IL247751B (en) | 2018-11-29 |
| MX381217B (es) | 2025-03-12 |
| TW201623238A (zh) | 2016-07-01 |
| KR20160138158A (ko) | 2016-12-02 |
| ES2699927T3 (es) | 2019-02-13 |
| TWI648263B (zh) | 2019-01-21 |
| WO2015140198A1 (de) | 2015-09-24 |
| US9890120B2 (en) | 2018-02-13 |
| BR112016021564B1 (pt) | 2021-03-23 |
| DK3119747T3 (da) | 2019-01-02 |
| KR102360975B1 (ko) | 2022-02-08 |
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