JP6533233B2 - ２，２−ジフルオロエチルアミンをアルキル化することによりｎ−［（６−クロロピリジノ−３−イル）メチル］−２，２−ジフルオロエタン−１−アミンを調製する方法 - Google Patents
２，２−ジフルオロエチルアミンをアルキル化することによりｎ−［（６−クロロピリジノ−３−イル）メチル］−２，２−ジフルオロエタン−１−アミンを調製する方法 Download PDFInfo
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- JP6533233B2 JP6533233B2 JP2016557945A JP2016557945A JP6533233B2 JP 6533233 B2 JP6533233 B2 JP 6533233B2 JP 2016557945 A JP2016557945 A JP 2016557945A JP 2016557945 A JP2016557945 A JP 2016557945A JP 6533233 B2 JP6533233 B2 JP 6533233B2
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- Prior art keywords
- reaction
- preparation
- methyl
- amine
- inorganic base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0255—Phosphorus containing compounds
- B01J31/0267—Phosphines or phosphonium compounds, i.e. phosphorus bonded to at least one carbon atom, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, the other atoms bonded to phosphorus being either carbon or hydrogen
- B01J31/0268—Phosphonium compounds, i.e. phosphine with an additional hydrogen or carbon atom bonded to phosphorous so as to result in a formal positive charge on phosphorous
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14161110 | 2014-03-21 | ||
| EP14161110.3 | 2014-03-21 | ||
| PCT/EP2015/055639 WO2015140198A1 (de) | 2014-03-21 | 2015-03-18 | Verfahren zur herstellung von n-[(6-chlorpyridin-3-yl)methyl]-2,2-difluorethan-1-amin durch alkylierung von 2,2-difluorethylamin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507989A JP2017507989A (ja) | 2017-03-23 |
| JP2017507989A5 JP2017507989A5 (enExample) | 2018-04-26 |
| JP6533233B2 true JP6533233B2 (ja) | 2019-06-19 |
Family
ID=50336216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016557945A Active JP6533233B2 (ja) | 2014-03-21 | 2015-03-18 | ２，２−ジフルオロエチルアミンをアルキル化することによりｎ−［（６−クロロピリジノ−３−イル）メチル］−２，２−ジフルオロエタン−１−アミンを調製する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9890120B2 (enExample) |
| EP (1) | EP3119747B1 (enExample) |
| JP (1) | JP6533233B2 (enExample) |
| KR (1) | KR102360975B1 (enExample) |
| CN (1) | CN106103412B (enExample) |
| BR (1) | BR112016021564B1 (enExample) |
| DK (1) | DK3119747T3 (enExample) |
| ES (1) | ES2699927T3 (enExample) |
| IL (1) | IL247751B (enExample) |
| MX (1) | MX381217B (enExample) |
| TW (1) | TWI648263B (enExample) |
| WO (1) | WO2015140198A1 (enExample) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006015467A1 (de) * | 2006-03-31 | 2007-10-04 | Bayer Cropscience Ag | Substituierte Enaminocarbonylverbindungen |
| DE102006033572A1 (de) * | 2006-07-20 | 2008-01-24 | Bayer Cropscience Ag | N'-Cyano-N-halogenalkyl-imidamid Derivate |
| EP2039684A1 (de) | 2007-09-18 | 2009-03-25 | Bayer CropScience AG | Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung |
| JP5329547B2 (ja) | 2007-09-18 | 2013-10-30 | バイエル・クロップサイエンス・アーゲー | アミドの水素化により２，２−ジフルオロエチルアミン誘導体を調製する方法 |
| EP2039678A1 (de) * | 2007-09-18 | 2009-03-25 | Bayer CropScience AG | Verfahren zum Herstellen von 4-Aminobut-2-enoliden |
| EP2264008A1 (de) * | 2009-06-18 | 2010-12-22 | Bayer CropScience AG | Substituierte Enaminocarbonylverbindungen |
| DK2582673T3 (da) * | 2010-06-15 | 2014-11-10 | Bayer Ip Gmbh | Fremgangsmåde til fremstilling af 2,2-difluorethylamin-derivater ved hjælp af alkylering med 2,2-difluor-1-halogenethaner |
| CN103313969A (zh) * | 2010-11-12 | 2013-09-18 | 拜耳知识产权有限责任公司 | 用于由n-(2，2-二氟乙基)丙-2-烯-1-胺起始制备2，2-二氟乙基胺衍生物的方法 |
| CN103242225B (zh) * | 2012-02-13 | 2016-01-06 | 湖南化工研究院 | 吡啶甲胺基吡啶类化合物及其制备方法 |
| JP6175136B2 (ja) * | 2012-06-29 | 2017-08-02 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ２，２−ジフルオロエチルアミンをアルキル化することによる２，２−ジフルオロエチルアミン誘導体の調製方法 |
-
2015
- 2015-03-18 BR BR112016021564-8A patent/BR112016021564B1/pt active IP Right Grant
- 2015-03-18 KR KR1020167029182A patent/KR102360975B1/ko active Active
- 2015-03-18 MX MX2016012057A patent/MX381217B/es unknown
- 2015-03-18 ES ES15710775T patent/ES2699927T3/es active Active
- 2015-03-18 EP EP15710775.6A patent/EP3119747B1/de active Active
- 2015-03-18 CN CN201580015173.3A patent/CN106103412B/zh active Active
- 2015-03-18 WO PCT/EP2015/055639 patent/WO2015140198A1/de not_active Ceased
- 2015-03-18 US US15/126,593 patent/US9890120B2/en active Active
- 2015-03-18 JP JP2016557945A patent/JP6533233B2/ja active Active
- 2015-03-18 DK DK15710775.6T patent/DK3119747T3/da active
- 2015-03-19 TW TW104108720A patent/TWI648263B/zh active
-
2016
- 2016-09-11 IL IL247751A patent/IL247751B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP3119747A1 (de) | 2017-01-25 |
| TW201623238A (zh) | 2016-07-01 |
| MX2016012057A (es) | 2017-01-19 |
| CN106103412B (zh) | 2019-03-19 |
| BR112016021564B1 (pt) | 2021-03-23 |
| CN106103412A (zh) | 2016-11-09 |
| BR112016021564A2 (pt) | 2017-10-03 |
| IL247751B (en) | 2018-11-29 |
| JP2017507989A (ja) | 2017-03-23 |
| MX381217B (es) | 2025-03-12 |
| EP3119747B1 (de) | 2018-08-29 |
| US20170081284A1 (en) | 2017-03-23 |
| KR20160138158A (ko) | 2016-12-02 |
| ES2699927T3 (es) | 2019-02-13 |
| TWI648263B (zh) | 2019-01-21 |
| US9890120B2 (en) | 2018-02-13 |
| DK3119747T3 (da) | 2019-01-02 |
| KR102360975B1 (ko) | 2022-02-08 |
| WO2015140198A1 (de) | 2015-09-24 |
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