CN106075158A - A kind of Chinese medicine composition treating acute simple gastritis and preparation method thereof - Google Patents

A kind of Chinese medicine composition treating acute simple gastritis and preparation method thereof Download PDF

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CN106075158A
CN106075158A CN201610649246.0A CN201610649246A CN106075158A CN 106075158 A CN106075158 A CN 106075158A CN 201610649246 A CN201610649246 A CN 201610649246A CN 106075158 A CN106075158 A CN 106075158A
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chinese medicine
medicine composition
treating acute
composition treating
mentholum
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李建敏
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

The invention discloses a kind of Chinese medicine composition treating acute simple gastritis, include following raw material by weight: the Radix Paeoniae Alba 35, Herba Belladonnae 35, Rhizoma Phragmitis 68, Mentholum 0.1 0.3, Fructus Aurantii Immaturus 68, Endothelium Corneum Gigeriae Galli 8 12, Rhizoma Corydalis 13, Semen Arecae 13.

Description

A kind of Chinese medicine composition treating acute simple gastritis and preparation method thereof
Technical field
The present invention relates to application and the preparation field of pharmaceuticals, relate to a kind of Chinese medicine composition treating acute simple gastritis Thing.
Background technology
Stomachache, also known as gastric abscess, refers to pain at the nearly pit of the stomach in upper abdomen gastral cavilty portion, and the traditional Chinese medical science thinks that stomachache is that taste are impaired, QI and blood The pain in uncomfortable caused gastral cavilty portion, how with diseases caused by exogenous pathogenic factor cold-evil, injury due to diet, feelings will is smooth and the cause of disease such as emptiness of spleen and stomach and draw Sending out, add that autumn and winter eating is pungent dry strong, dry weather, the people suffering from stomachache gets more and more;The acute gastritis of doctor trained in Western medicine, chronic gastritis, The above abdominal pains such as gastric ulcer, duodenal ulcer, functional digestive obstacle are cardinal symptom, belong to Chinese medicine acute merely Property gastritis scope.At present the method for the treatment of acute simple gastritis has Chinese traditional treatment and western medical treatment, western medical treatment typically with Ah Amdinocillin+omeprazole+metronidazole, i.e. triple therapy, antacid infection is main, substantially can only alleviate or release symptom, and And long-term taking antibiotic, injure one's stomach gas, causes patient's anorexia, malnutrition, and health is weaker.The traditional Chinese medical science is empty with cold and heat Real, coldheat complex, relatively common, but ignore taste prolonged deficiency, long-pending silt is not smooth, and only balance taste negative and positive are not enough.Therefore lead Causing unsatisfactory curative effect, Most patients feedback is only stomachache transference cure, but dietary amount does not increases, and digests and assimilates and do not changed Kind.
Summary of the invention
It is an object of the invention to provide one and treat stomachache, and appetite and the Chinese medicine composition digested and assimilated can be improved.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition treating acute simple gastritis, including the raw material of following weight portion: Radix Paeoniae Alba 3-5, Semen daturae Grass 3-5, Rhizoma Phragmitis 6-8, Mentholum 0.1-0.3, Fructus Aurantii Immaturus 6-8, Endothelium Corneum Gigeriae Galli 8-12, Rhizoma Corydalis 1-3, Semen Arecae 1-3.
Preferably, including the raw material of following weight portion: the Radix Paeoniae Alba 4, Herba Belladonnae 4, Rhizoma Phragmitis 7, Mentholum 0.2, Fructus Aurantii Immaturus 7, in chicken Gold 10, Rhizoma Corydalis 2, Semen Arecae 2.
The present invention also provides for the preparation method of a kind of Chinese medicine composition treating acute simple gastritis: comprise following process Step: take the Radix Paeoniae Alba of each weight portion, Herba Belladonnae, Rhizoma Phragmitis, Mentholum, Fructus Aurantii Immaturus, Endothelium Corneum Gigeriae Galli, Rhizoma Corydalis, Semen Arecae by proportion relation;Add 70% ethanol soaks 15 minutes at 60~65 DEG C, reflux, extract, 2-3 time, each 1 hour, and 100 mesh filters filter, and obtain extracting solution; United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution;By concentrated solution at 70-100 DEG C Being spray-dried or dry, be ground into the fine powder of 70-100 mesh, after granulation, Conventional compression or encapsulated, to obtain final product.
Prescription of the present invention is exquisite, each component synergism, analgesia of releiving, clearing stomach spleen invigorating, and blood stasis dispelling removing mass is insufficiency of the spleen for gastric heat Person is especially suitable.
Detailed description of the invention
Embodiment 1
(1) take the Radix Paeoniae Alba 3 parts, Herba Belladonnae 3 parts, Rhizoma Phragmitis 6 parts, Mentholum 0.1 part, Fructus Aurantii Immaturus 6 parts, Endothelium Corneum Gigeriae Galli 8 parts, Rhizoma Corydalis 1 part, Semen Arecae 1 part is standby;
(2) adding 70% ethanol to soak 15 minutes at 60 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters filter, Extracting solution;United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution;By concentrated solution 70 DEG C be spray-dried or dry, be ground into the fine powder of 70 mesh, encapsulated after granulation, specification 0.45g/ grain. each 3 times of morning, noon and afternoon, ante cibum Take, each 3-5 grain.
Embodiment 2
(1) Radix Paeoniae Alba 5 parts, Herba Belladonnae 5 parts, Rhizoma Phragmitis 8 parts, Mentholum 0.3 part, Fructus Aurantii Immaturus 8 parts, Endothelium Corneum Gigeriae Galli 12 parts, Rhizoma Corydalis 3 are taken Part, Semen Arecae 3 parts standby;
(2) adding 70% ethanol to soak 15 minutes at 65 DEG C, reflux, extract, 3 times, each 1 hour, 100 mesh filters filter, Extracting solution;United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution;Concentrated solution is existed 100 DEG C are spray-dried or dry, are ground into the fine powder of 100 mesh, encapsulated after granulation, specification 0.45g/ grain.
Embodiment 3
(1) Radix Paeoniae Alba 4 parts, Herba Belladonnae 4 parts, Rhizoma Phragmitis 7 parts, Mentholum 0.2 part, Fructus Aurantii Immaturus 7 parts, Endothelium Corneum Gigeriae Galli 10 parts, Rhizoma Corydalis 2 are taken Part, Semen Arecae 2 parts standby;
(2) adding 70% ethanol to soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters filter, Extracting solution;United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution;By concentrated solution 80 DEG C be spray-dried or dry, be ground into the fine powder of 90 mesh, encapsulated after granulation, specification 0.45g/ grain.
Clinical efficacy data
1, the effect observation that has a stomach-ache is treated
1.1 objects: acute simple gastritis observes 800 people, with gastralgia, hyperchlorhydria and the chronic dietary stagnation of QI, big Just the hardest rear half congealed, belch, stomach has burn feeling.
1.2 medicines composition: the Radix Paeoniae Alba 400 grams, Herba Belladonnae 400 grams, Rhizoma Phragmitis 700 grams, Mentholum 20 grams, Fructus Aurantii Immaturus 700 grams, Endothelium Corneum Gigeriae Galli 1000 grams, Rhizoma Corydalis 200 grams, Semen Arecae 200 grams.
Said medicine adds 70% ethanol soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters Filter, obtain extracting solution;United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution;By dense Contracting liquid is spray-dried at 80 DEG C or dries, and is ground into the fine powder of 90 mesh, and encapsulated after granulation, specification 0.45g/ grain, the morning, noon and afternoon are each Once, bfore meals, each 3-5 grain.
1.3 curative effect judging standards:
Cure: gastralgia and other transference cures, x line, canel barium meal contrast examination or gastroscopy are normal.
Taking a turn for the better: stomachache is alleviated, outbreak reduces, other symptoms alleviate.
Not healing: x line, canel barium meal contrast examination or gastroscopy are the same with premorbid, symptom is without improving
And improvement.
Treatment stomachache 600 example effects
After using 30 days, 600 examples effective 475 examples of stomachache, take a turn for the better 89 examples, invalid 36 examples, obvious effective rate 79%, improvement rate 15%, total effective rate 94%.In use, all user all reflect that appetite improves, appetite increase, and stool form and Color makes moderate progress.

Claims (3)

1. the Chinese medicine composition treating acute simple gastritis, it is characterised in that include the raw material of following weight portion: the Radix Paeoniae Alba 3-5, Herba Belladonnae 3-5, Rhizoma Phragmitis 6-8, Mentholum 0.1-0.3, Fructus Aurantii Immaturus 6-8, Endothelium Corneum Gigeriae Galli 8-12, Rhizoma Corydalis 1-3, Semen Arecae 1-3.
A kind of Chinese medicine composition treating acute simple gastritis the most according to claim 1, it is characterised in that include with The raw material of lower weight portion: the Radix Paeoniae Alba 4, Herba Belladonnae 4, Rhizoma Phragmitis 7, Mentholum 0.2, Fructus Aurantii Immaturus 7, Endothelium Corneum Gigeriae Galli 10, Rhizoma Corydalis 2, Semen Arecae 2.
The preparation method of a kind of Chinese medicine composition treating acute simple gastritis the most according to claim 1 and 2: it is special Levy and be to comprise following process steps: take the Radix Paeoniae Alba of each weight portion, Herba Belladonnae, Rhizoma Phragmitis, Mentholum, Fructus Aurantii Immaturus, chicken by proportion relation Endothelium corneum, Rhizoma Corydalis, Semen Arecae;Add 70% ethanol to soak 15 minutes at 60~65 DEG C, reflux, extract, 2-3 time, each 1 hour, 100 mesh filters Device filters, and obtains extracting solution;United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution;Will Concentrated solution is spray-dried at 70-100 DEG C or dries, and is ground into the fine powder of 70-100 mesh, Conventional compression or encapsulated after granulation, i.e. ?.
CN201610649246.0A 2016-08-10 2016-08-10 A kind of Chinese medicine composition treating acute simple gastritis and preparation method thereof Pending CN106075158A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104083720A (en) * 2014-07-02 2014-10-08 卞佳林 Traditional Chinese medicine preparation for treating chronic gastritis as well as preparation method and application of traditional Chinese medicine preparation
CN105362778A (en) * 2015-12-14 2016-03-02 李建敏 Traditional Chinese medicine composition for treating reflux gastritis and preparation method of traditional Chinese medicine composition
CN105412836A (en) * 2015-12-21 2016-03-23 李建敏 Traditional Chinese medicine composition for treating stomach heat and preparation method of traditional Chinese medicine composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104083720A (en) * 2014-07-02 2014-10-08 卞佳林 Traditional Chinese medicine preparation for treating chronic gastritis as well as preparation method and application of traditional Chinese medicine preparation
CN105362778A (en) * 2015-12-14 2016-03-02 李建敏 Traditional Chinese medicine composition for treating reflux gastritis and preparation method of traditional Chinese medicine composition
CN105412836A (en) * 2015-12-21 2016-03-23 李建敏 Traditional Chinese medicine composition for treating stomach heat and preparation method of traditional Chinese medicine composition

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Application publication date: 20161109