CN105395733A - Traditional Chinese medicine composition used for treating chronic gastritis and preparation method therefor - Google Patents

Traditional Chinese medicine composition used for treating chronic gastritis and preparation method therefor Download PDF

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Publication number
CN105395733A
CN105395733A CN201510925517.6A CN201510925517A CN105395733A CN 105395733 A CN105395733 A CN 105395733A CN 201510925517 A CN201510925517 A CN 201510925517A CN 105395733 A CN105395733 A CN 105395733A
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herba
parts
chinese medicine
medicine composition
treatment
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李建敏
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine composition used for treating chronic gastritis. The traditional Chinese medicine composition comprises the following raw materials, by weight, 3-5 parts of Chinese angelica, 3-5 parts of belladonna, 6-8 parts of rhizoma calami, 1-3 parts of Chinese prickly ash, 6-8 parts of dried orange peel, 8-12 parts of striga asiatica, 1-3 parts of safflower and 1-3 parts of saussurea involucrate.

Description

A kind of Chinese medicine composition being used for the treatment of gastritis and preparation method thereof
Technical field
The present invention relates to application and the preparation field of pharmaceuticals, relate to a kind of Chinese medicine composition being used for the treatment of gastritis.
Background technology
Stomachache is also known as gastric abscess, refer to upper abdomen gastral cavilty portion nearly pit of the stomach place pain, the traditional Chinese medical science thinks that stomachache is that taste are impaired, the pain in gastral cavilty portion caused by qi and blood disorder, mainly with diseases caused by exogenous pathogenic factor cold-evil, the causes of disease such as the smooth and emptiness of spleen and stomach of injury due to diet, feelings will and causing, add that modern's eating raw food is cold and cool, pressure is excessive, and the people suffering from stomachache gets more and more; The above abdominal pain such as acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, functional digestive obstacle of doctor trained in Western medicine is cardinal symptom, belongs to Chinese medicine gastropathy scope.The method of current treatment gastropathy has Chinese traditional treatment and western medical treatment, western medical treatment is generally with amoxicillin+omeprazole+metronidazole, i.e. triple therapy, antacid infection is main, substantially can only alleviate or remove symptom, and long-term taking antibiotic, injure one's stomach gas, cause patient's anorexia, malnutrition, health is weaker.The traditional Chinese medical science is with cold and heat and asthenia and sthenia, coldheat complex, more common, but ignores taste prolonged deficiency, and long-pending silt is not smooth, only balances taste negative and positive not enough.Therefore cause unsatisfactory curative effect, Most patients feedback is only stomachache transference cure, but dietary amount does not increase, and digests and assimilates and do not improve.
Summary of the invention
One is the object of the present invention is to provide to treat stomachache, and the Chinese medicine composition that can improve appetite and digest and assimilate.
The present invention is achieved through the following technical solutions:
Be used for the treatment of a Chinese medicine composition for gastritis, comprise the raw material of following weight portion: Radix Angelicae Sinensis 3-5, Herba Belladonnae 3-5, Rhizoma Acori Calami 6-8, Pericarpium Zanthoxyli 1-3, Pericarpium Citri Reticulatae 6-8, Herba Lobeliae Chinensis 8-12, Flos Carthami 1-3, Herba Saussureae Involueratae 1-3.
Preferably, comprise the raw material of following weight portion: Radix Angelicae Sinensis 4, Herba Belladonnae 4, Rhizoma Acori Calami 7, Pericarpium Zanthoxyli 2, Pericarpium Citri Reticulatae 7, Herba Lobeliae Chinensis 10, Flos Carthami 2, Herba Saussureae Involueratae 2.
The present invention also provides a kind of preparation method being used for the treatment of the Chinese medicine composition of gastritis: comprise following process steps: the Radix Angelicae Sinensis getting each weight portion by proportion relation, Herba Belladonnae, Rhizoma Acori Calami, Pericarpium Zanthoxyli, Pericarpium Citri Reticulatae, Herba Lobeliae Chinensis, Flos Carthami, Herba Saussureae Involueratae; Add 70% ethanol to soak 15 minutes at 60 ~ 65 DEG C, reflux, extract, 2-3 time, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 70-100 DEG C of spraying dry or oven dry, be ground into 70-100 object fine powder, Conventional compression or encapsulated after granulating, to obtain final product.
Prescription of the present invention is exquisite, each component synergism, analgesia of releiving, warming the stomach spleen invigorating, and desilting helps digestion, warming spleen and stomach for dispelling cold, especially applicable for cold syndrome of the stomach person with Spleen Deficiency.
Detailed description of the invention
Embodiment 1
(1) get Radix Angelicae Sinensis 3 parts, Herba Belladonnae 3 parts, Rhizoma Acori Calami 6 parts, 1 part, Pericarpium Zanthoxyli, Pericarpium Citri Reticulatae 6 parts, Herba Lobeliae Chinensis 8 parts, 1 part, Flos Carthami, Herba Saussureae Involueratae 1 part are for subsequent use;
(2) add 70% ethanol to soak 15 minutes at 60 DEG C, reflux, extract, 2 times, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 70 DEG C of spraying dry or oven dry, be ground into 70 object fine powders, encapsulated after granulating, specification 0.45g/ grain. each 3 times of morning, noon and afternoon, bfore meals, each 3-5 grain.
Embodiment 2
(1) get Radix Angelicae Sinensis 5 parts, Herba Belladonnae 5 parts, Rhizoma Acori Calami 8 parts, 3 parts, Pericarpium Zanthoxyli, Pericarpium Citri Reticulatae 8 parts, Herba Lobeliae Chinensis 12 parts, 3 parts, Flos Carthami, Herba Saussureae Involueratae 3 parts are for subsequent use;
(2) add 70% ethanol to soak 15 minutes at 65 DEG C, reflux, extract, 3 times, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 100 DEG C of spraying dry or oven dry, be ground into 100 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 3
(1) get Radix Angelicae Sinensis 4 parts, Herba Belladonnae 4 parts, Rhizoma Acori Calami 7 parts, 2 parts, Pericarpium Zanthoxyli, Pericarpium Citri Reticulatae 7 parts, Herba Lobeliae Chinensis 10 parts, 2 parts, Flos Carthami, Herba Saussureae Involueratae 2 parts are for subsequent use;
(2) add 70% ethanol to soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 80 DEG C of spraying dry or oven dry, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Clinical efficacy data
1, the effect observation that has a stomach-ache is treated
1.1 objects: gastropathy observes 500 people, with gastralgia, hyperchlorhydria and the chronic dietary stagnation of QI, stool first hard rear half congealed, belch.
1.2 medicine compositions: Radix Angelicae Sinensis 400 grams, Herba Belladonnae 400 grams, Rhizoma Acori Calami 700 grams, 200 grams, Pericarpium Zanthoxyli, Pericarpium Citri Reticulatae 700 grams, Herba Lobeliae Chinensis 1000 grams, 200 grams, Flos Carthami, Herba Saussureae Involueratae 200 grams.
Said medicine is added 70% ethanol to soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 80 DEG C of spraying dry or oven dry, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain, the morning, noon and afternoon are respectively once, bfore meals, each 3-5 grain.
1.3 curative effect judging standards:
Cure: gastralgia and other transference cures, x line, canel barium meal contrast examination or gastroscopy are normal.
Take a turn for the better: stomachache is alleviated, outbreak minimizing, other symptoms alleviate.
Do not heal: x line, canel barium meal contrast examination or gastroscopy are the same with premorbid, symptom is without improvement and take a turn for the better.
The routine effect for the treatment of stomachache 700
Use after 30 days, effective 551 examples of 700 example stomachache, take a turn for the better 107 examples, invalid 42 examples, obvious effective rate 79%, improvement rate 15%, total effective rate 94%.In use, all user all reflect that appetite improves, and appetite increases, and stool form and color make moderate progress.

Claims (3)

1. be used for the treatment of a Chinese medicine composition for gastritis, it is characterized in that, comprise the raw material of following weight portion: Radix Angelicae Sinensis 3-5, Herba Belladonnae 3-5, Rhizoma Acori Calami 6-8, Pericarpium Zanthoxyli 1-3, Pericarpium Citri Reticulatae 6-8, Herba Lobeliae Chinensis 8-12, Flos Carthami 1-3, Herba Saussureae Involueratae 1-3.
2. a kind of Chinese medicine composition being used for the treatment of gastritis according to claim 1, is characterized in that, comprise the raw material of following weight portion: Radix Angelicae Sinensis 4, Herba Belladonnae 4, Rhizoma Acori Calami 7, Pericarpium Zanthoxyli 2, Pericarpium Citri Reticulatae 7, Herba Lobeliae Chinensis 10, Flos Carthami 2, Herba Saussureae Involueratae 2.
3. a kind of preparation method being used for the treatment of the Chinese medicine composition of gastritis according to claim 1 and 2: it is characterized in that comprising following process steps: the Radix Angelicae Sinensis getting each weight portion by proportion relation, Herba Belladonnae, Rhizoma Acori Calami, Pericarpium Zanthoxyli, Pericarpium Citri Reticulatae, Herba Lobeliae Chinensis, Flos Carthami, Herba Saussureae Involueratae; Add 70% ethanol to soak 15 minutes at 60 ~ 65 DEG C, reflux, extract, 2-3 time, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 70-100 DEG C of spraying dry or oven dry, be ground into 70-100 object fine powder, Conventional compression or encapsulated after granulating, to obtain final product.
CN201510925517.6A 2015-12-11 2015-12-11 Traditional Chinese medicine composition used for treating chronic gastritis and preparation method therefor Pending CN105395733A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107536977B (en) * 2017-08-09 2021-01-08 张振亚 Composition with stomach discomfort smoothing effect and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102058844A (en) * 2010-11-24 2011-05-18 荣成市港圆抽纱制品有限公司 Traditional Chinese medicine composition for treating gastritis
CN103394040A (en) * 2013-08-06 2013-11-20 天津太平洋制药有限公司 Drug for treatment of atrophic gastritis
CN104383071A (en) * 2014-11-20 2015-03-04 张进良 Medicine composition with capability of strengthening spleen and stomach

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102058844A (en) * 2010-11-24 2011-05-18 荣成市港圆抽纱制品有限公司 Traditional Chinese medicine composition for treating gastritis
CN103394040A (en) * 2013-08-06 2013-11-20 天津太平洋制药有限公司 Drug for treatment of atrophic gastritis
CN104383071A (en) * 2014-11-20 2015-03-04 张进良 Medicine composition with capability of strengthening spleen and stomach

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107536977B (en) * 2017-08-09 2021-01-08 张振亚 Composition with stomach discomfort smoothing effect and preparation method thereof

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Application publication date: 20160316