CN106109812A - A kind of Chinese medicine composition treating hyperchlorhydria and preparation method thereof - Google Patents

A kind of Chinese medicine composition treating hyperchlorhydria and preparation method thereof Download PDF

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CN106109812A
CN106109812A CN201610652513.XA CN201610652513A CN106109812A CN 106109812 A CN106109812 A CN 106109812A CN 201610652513 A CN201610652513 A CN 201610652513A CN 106109812 A CN106109812 A CN 106109812A
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chinese medicine
medicine composition
composition treating
radix ginseng
fructus
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李建敏
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a kind of Chinese medicine composition treating hyperchlorhydria, include following raw material by weight: Radix Ginseng 13, Herba Belladonnae 35, Calyx Kaki 8 10, Fructus Evodiae 13, Fructus Citri Sarcodactylis 68, Endothelium Corneum Gigeriae Galli 8 12, Rhizoma Cyperi 13, Semen Cuscutae 13.

Description

A kind of Chinese medicine composition treating hyperchlorhydria and preparation method thereof
Technical field
The present invention relates to application and the preparation field of pharmaceuticals, relate to a kind of Chinese medicine composition treating hyperchlorhydria.
Background technology
Stomachache, also known as gastric abscess, refers to pain at the nearly pit of the stomach in upper abdomen gastral cavilty portion, and the traditional Chinese medical science thinks that stomachache is that taste are impaired, QI and blood The pain in uncomfortable caused gastral cavilty portion, how with diseases caused by exogenous pathogenic factor cold-evil, injury due to diet, feelings will is smooth and the cause of disease such as emptiness of spleen and stomach and draw Sending out, add that modern's eating raw food is cold and cool, pressure is excessive, and the people suffering from stomachache gets more and more；The acute gastritis of doctor trained in Western medicine, chronic stomach The above abdominal pains such as inflammation, gastric ulcer, duodenal ulcer, functional digestive obstacle are cardinal symptom, belong to Chinese medicine gastric acid Cross multiregion.The method for the treatment of hyperchlorhydria has Chinese traditional treatment and western medical treatment at present, and western medical treatment is typically with amoxicillin+Austria U.S.A draws azoles+metronidazole, i.e. triple therapy, antacid infection to be main, substantially can only alleviate or release symptom, and long-term taking Antibiotic, injure one's stomach gas, causes patient's anorexia, malnutrition, and health is weaker.The traditional Chinese medical science is wrong with cold and heat and asthenia and sthenia, cold and heat Miscellaneous, relatively common, but ignore taste prolonged deficiency, long-pending silt is not smooth, and only balance taste negative and positive are not enough.Therefore curative effect is caused not Good, Most patients feedback is only stomachache transference cure, but dietary amount does not increases, and digests and assimilates and do not improved.
Summary of the invention
It is an object of the invention to provide one and treat stomachache, and appetite and the Chinese medicine composition digested and assimilated can be improved.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition treating hyperchlorhydria, including the raw material of following weight portion: Radix Ginseng 1-3, Herba Belladonnae 3-5, Calyx Kaki 8-10, Fructus Evodiae 1-3, Fructus Citri Sarcodactylis 6-8, Endothelium Corneum Gigeriae Galli 8-12, Rhizoma Cyperi 1-3, Semen Cuscutae 1-3.
Preferably, including the raw material of following weight portion: Radix Ginseng 2, Herba Belladonnae 4, Calyx Kaki 9, Fructus Evodiae 2, Fructus Citri Sarcodactylis 7, Endothelium Corneum Gigeriae Galli 10, Rhizoma Cyperi 2, Semen Cuscutae 2.
The present invention also provides for the preparation method of a kind of Chinese medicine composition treating hyperchlorhydria: comprise following process steps: The Radix Ginseng of each weight portion, Herba Belladonnae, Calyx Kaki, Fructus Evodiae, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Rhizoma Cyperi, Semen Cuscutae is taken by proportion relation；Add 70% Ethanol soaks 15 minutes at 60～65 DEG C, reflux, extract, 2-3 time, each 1 hour, and 100 mesh filters filter, and obtain extracting solution；Merge Extracting solution, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By concentrated solution 70-100 DEG C of spraying Being dried or dry, be ground into the fine powder of 70-100 mesh, after granulation, Conventional compression or encapsulated, to obtain final product.
Prescription of the present invention is exquisite, each component synergism, analgesia of releiving, and warming the stomach spleen invigorating, desilting helps digestion, insufficiency of the spleen for cold syndrome of the stomach Person is especially suitable.
Detailed description of the invention
Embodiment 1
(1) Radix Ginseng 1 part, Herba Belladonnae 3 parts, Calyx Kaki 8 parts, Fructus Evodiae 1 part, Fructus Citri Sarcodactylis 6 parts, Endothelium Corneum Gigeriae Galli 8 parts, Rhizoma Cyperi 1 part, Tu are taken SIZI 1 part is standby；
(2) adding 70% ethanol to soak 15 minutes at 60 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters filter, Extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By concentrated solution 70 DEG C be spray-dried or dry, be ground into the fine powder of 70 mesh, encapsulated after granulation, specification 0.45g/ grain. each 3 times of morning, noon and afternoon, ante cibum Take, each 3-5 grain.
Embodiment 2
(1) take Radix Ginseng 3 parts, Herba Belladonnae 5 parts, Calyx Kaki 10 parts, Fructus Evodiae 3 parts, Fructus Citri Sarcodactylis 8 parts, Endothelium Corneum Gigeriae Galli 12 parts, Rhizoma Cyperi 3 parts, Semen Cuscutae 3 parts is standby；
(2) adding 70% ethanol to soak 15 minutes at 65 DEG C, reflux, extract, 3 times, each 1 hour, 100 mesh filters filter, Extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；Concentrated solution is existed 100 DEG C are spray-dried or dry, are ground into the fine powder of 100 mesh, encapsulated after granulation, specification 0.45g/ grain.
Embodiment 3
(1) take Radix Ginseng 2 parts, Herba Belladonnae 4 parts, Calyx Kaki 9 parts, Fructus Evodiae 2 parts, Fructus Citri Sarcodactylis 7 parts, Endothelium Corneum Gigeriae Galli 10 parts, Rhizoma Cyperi 2 parts, Semen Cuscutae 2 parts is standby；
(2) adding 70% ethanol to soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters filter, Extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By concentrated solution 80 DEG C be spray-dried or dry, be ground into the fine powder of 90 mesh, encapsulated after granulation, specification 0.45g/ grain.
Clinical efficacy data
1, the effect observation that has a stomach-ache is treated
1.1 objects: hyperchlorhydria observes 400 people, with gastralgia, hyperchlorhydria and the chronic dietary stagnation of QI, defecate the most firmly The most half congealed, belch.
1.2 medicine compositions: Radix Ginseng 200 grams, Herba Belladonnae 400 grams, Calyx Kaki 900 grams, Fructus Evodiae 200 grams, Fructus Citri Sarcodactylis 700 Gram, Endothelium Corneum Gigeriae Galli 1000 grams, Rhizoma Cyperi 200 grams, Semen Cuscutae 200 grams.
Said medicine adds 70% ethanol soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters Filter, obtain extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By dense Contracting liquid is spray-dried at 80 DEG C or dries, and is ground into the fine powder of 90 mesh, and encapsulated after granulation, specification 0.45g/ grain, the morning, noon and afternoon are each Once, bfore meals, each 3-5 grain.
1.3 curative effect judging standards:
Cure: gastralgia and other transference cures, x line, canel barium meal contrast examination or gastroscopy are normal.
Taking a turn for the better: stomachache is alleviated, outbreak reduces, other symptoms alleviate.
Not healing: x line, canel barium meal contrast examination or gastroscopy are the same with premorbid, symptom is without improving and taking a turn for the better.
Treatment stomachache 400 example effects
After using 30 days, 400 examples effective 294 examples of stomachache, take a turn for the better 89 examples, invalid 17 examples, obvious effective rate 74%, improvement rate 22%, total effective rate 96%.In use, all user all reflect that appetite improves, appetite increase, and stool form and Color makes moderate progress.

Claims (3)

1. the Chinese medicine composition treating hyperchlorhydria, it is characterised in that include the raw material of following weight portion: Radix Ginseng 1-3, top Eggplant grass 3-5, Calyx Kaki 8-10, Fructus Evodiae 1-3, Fructus Citri Sarcodactylis 6-8, Endothelium Corneum Gigeriae Galli 8-12, Rhizoma Cyperi 1-3, Semen Cuscutae 1-3.
A kind of Chinese medicine composition treating hyperchlorhydria the most according to claim 1, it is characterised in that include following weight The raw material of part: Radix Ginseng 2, Herba Belladonnae 4, Calyx Kaki 9, Fructus Evodiae 2, Fructus Citri Sarcodactylis 7, Endothelium Corneum Gigeriae Galli 10, Rhizoma Cyperi 2, Semen Cuscutae 2.
The preparation method of a kind of Chinese medicine composition treating hyperchlorhydria the most according to claim 1 and 2: it is characterized in that Comprise following process steps: take the Radix Ginseng of each weight portion, Herba Belladonnae, Calyx Kaki, Fructus Evodiae, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, perfume by proportion relation Attached, Semen Cuscutae；Add 70% ethanol to soak 15 minutes at 60～65 DEG C, reflux, extract, 2-3 time, each 1 hour, 100 mesh filter filters Cross, obtain extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；To concentrate Liquid is spray-dried at 70-100 DEG C or dries, and is ground into the fine powder of 70-100 mesh, and after granulation, Conventional compression or encapsulated, to obtain final product.
CN201610652513.XA 2016-08-10 2016-08-10 A kind of Chinese medicine composition treating hyperchlorhydria and preparation method thereof Pending CN106109812A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102309711A (en) * 2010-06-30 2012-01-11 王东 Traditional Chinese medicine (TCM) prescription for treating gastroduodenal ulcer
CN102343062A (en) * 2010-07-30 2012-02-08 李普华 Traditional Chinese medicine for treating gastric hyperacidity
CN102406903A (en) * 2011-11-30 2012-04-11 宋爱民 Traditional Chinese preparation for treating gastroxynsis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102309711A (en) * 2010-06-30 2012-01-11 王东 Traditional Chinese medicine (TCM) prescription for treating gastroduodenal ulcer
CN102343062A (en) * 2010-07-30 2012-02-08 李普华 Traditional Chinese medicine for treating gastric hyperacidity
CN102406903A (en) * 2011-11-30 2012-04-11 宋爱民 Traditional Chinese preparation for treating gastroxynsis

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