CN106177846A - A kind of Chinese medicine composition treating erosive gastritis and preparation method thereof - Google Patents

A kind of Chinese medicine composition treating erosive gastritis and preparation method thereof Download PDF

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CN106177846A
CN106177846A CN201610649137.9A CN201610649137A CN106177846A CN 106177846 A CN106177846 A CN 106177846A CN 201610649137 A CN201610649137 A CN 201610649137A CN 106177846 A CN106177846 A CN 106177846A
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herba
chinese medicine
medicine composition
composition treating
radix
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李建敏
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
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Abstract

The invention discloses a kind of Chinese medicine composition treating erosive gastritis, include following raw material by weight: Radix Angelicae Sinensis 35, Herba Belladonnae 35, Radix Pecteilis susannae 68, Herba Asari 13, Fructus Caryophylli 68, Endothelium Corneum Gigeriae Galli 8 12, Rhizoma Zingiberis 13, Herba Cynomorii 13.

Description

A kind of Chinese medicine composition treating erosive gastritis and preparation method thereof
Technical field
The present invention relates to application and the preparation field of pharmaceuticals, relate to a kind of Chinese medicine composition treating erosive gastritis.
Background technology
Stomachache, also known as gastric abscess, refers to pain at the nearly pit of the stomach in upper abdomen gastral cavilty portion, and the traditional Chinese medical science thinks that stomachache is that taste are impaired, QI and blood The pain in uncomfortable caused gastral cavilty portion, how with diseases caused by exogenous pathogenic factor cold-evil, injury due to diet, feelings will is smooth and the cause of disease such as emptiness of spleen and stomach and draw Sending out, add that modern's eating raw food is cold and cool, pressure is excessive, and the people of stomach discomfort gets more and more；The acute gastritis of doctor trained in Western medicine, chronic stomach The above abdominal pains such as inflammation, gastric ulcer, duodenal ulcer, functional digestive obstacle are cardinal symptom, belong to Chinese medicine rotten to the corn Property gastritis scope.The method for the treatment of erosive gastritis has Chinese traditional treatment and western medical treatment at present, and western medical treatment is typically with A Moxi Woods+omeprazole+metronidazole, i.e. triple therapy, antacid infection is main, substantially can only alleviate or release symptom, and long Phase takes antibiotic, and injure one's stomach gas, causes patient's anorexia, malnutrition, and health is weaker.The traditional Chinese medical science with cold and heat and asthenia and sthenia, Coldheat complex, relatively common, but ignore taste prolonged deficiency, long-pending silt is not smooth, and only balance taste negative and positive are not enough.Therefore cause treating Imitating the best, Most patients feedback is only stomachache transference cure, but dietary amount does not increases, and digests and assimilates and do not improved.
Summary of the invention
It is an object of the invention to provide one and treat stomachache, and appetite and the Chinese medicine composition digested and assimilated can be improved.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition treating erosive gastritis, including the raw material of following weight portion: Radix Angelicae Sinensis 3-5, Herba Belladonnae 3- 5, Radix Pecteilis susannae 6-8, Herba Asari 1-3, Fructus Caryophylli 6-8, Endothelium Corneum Gigeriae Galli 8-12, Rhizoma Zingiberis 1-3, Herba Cynomorii 1-3.
Preferably, including the raw material of following weight portion: Radix Angelicae Sinensis 4, Herba Belladonnae 4, Radix Pecteilis susannae 7, Herba Asari 2, Fructus Caryophylli 7, in chicken Gold 10, Rhizoma Zingiberis 2, Herba Cynomorii 2.
The present invention also provides for the preparation method of a kind of Chinese medicine composition treating erosive gastritis: comprise following process step Rapid: take the Radix Angelicae Sinensis of each weight portion, Herba Belladonnae, Radix Pecteilis susannae, Herba Asari, Fructus Caryophylli, Endothelium Corneum Gigeriae Galli, Rhizoma Zingiberis, Herba Cynomorii by proportion relation；Add 70% ethanol soaks 15 minutes at 60～65 DEG C, reflux, extract, 2-3 time, each 1 hour, and 100 mesh filters filter, and obtain extracting solution； United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By concentrated solution at 70-100 DEG C Being spray-dried or dry, be ground into the fine powder of 70-100 mesh, after granulation, Conventional compression or encapsulated, to obtain final product.
Prescription of the present invention is exquisite, each component synergism, analgesia of releiving, warming the stomach spleen invigorating, and removing mass is logical to become silted up, insufficiency of the spleen for cold syndrome of the stomach Person is especially suitable.
Detailed description of the invention
Embodiment 1
(1) take Radix Angelicae Sinensis 3 parts, Herba Belladonnae 3 parts, Radix Pecteilis susannae 6 parts, Herba Asari 1 part, Fructus Caryophylli 6 parts, Endothelium Corneum Gigeriae Galli 8 parts, Rhizoma Zingiberis 1 part, Herba Cynomorii 1 part is standby；
(2) adding 70% ethanol to soak 15 minutes at 60 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters filter, Extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By concentrated solution 70 DEG C be spray-dried or dry, be ground into the fine powder of 70 mesh, encapsulated after granulation, specification 0.45g/ grain. each 3 times of morning, noon and afternoon, ante cibum Take, each 3-5 grain.
Embodiment 2
(1) Radix Angelicae Sinensis 5 parts, Herba Belladonnae 5 parts, Radix Pecteilis susannae 8 parts, Herba Asari 3 parts, Fructus Caryophylli 8 parts, Endothelium Corneum Gigeriae Galli 12 parts, Rhizoma Zingiberis 3 are taken Part, Herba Cynomorii 3 parts standby；
(2) adding 70% ethanol to soak 15 minutes at 65 DEG C, reflux, extract, 3 times, each 1 hour, 100 mesh filters filter, Extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；Concentrated solution is existed 100 DEG C are spray-dried or dry, are ground into the fine powder of 100 mesh, encapsulated after granulation, specification 0.45g/ grain.
Embodiment 3
(1) Radix Angelicae Sinensis 4 parts, Herba Belladonnae 4 parts, Radix Pecteilis susannae 7 parts, Herba Asari 2 parts, Fructus Caryophylli 7 parts, Endothelium Corneum Gigeriae Galli 10 parts, Rhizoma Zingiberis 2 are taken Part, Herba Cynomorii 2 parts standby；
(2) adding 70% ethanol to soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters filter, Extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By concentrated solution 80 DEG C be spray-dried or dry, be ground into the fine powder of 90 mesh, encapsulated after granulation, specification 0.45g/ grain.
Clinical efficacy data
1, the effect observation that has a stomach-ache is treated
1.1 objects: erosive gastritis observes 600 people, with gastralgia, hyperchlorhydria and the chronic dietary stagnation of QI, defecate first Half congealed, belch after hard.
1.2 medicine compositions: Radix Angelicae Sinensis 400 grams, Herba Belladonnae 400 grams, Radix Pecteilis susannae 700 grams, Herba Asari 200 grams, Fructus Caryophylli 700 Gram, Endothelium Corneum Gigeriae Galli 1000 grams, Rhizoma Zingiberis 200 grams, Herba Cynomorii 200 grams.
Said medicine adds 70% ethanol soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 mesh filters Filter, obtain extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By dense Contracting liquid is spray-dried at 80 DEG C or dries, and is ground into the fine powder of 90 mesh, and encapsulated after granulation, specification 0.45g/ grain, the morning, noon and afternoon are each Once, bfore meals, each 3-5 grain.
1.3 curative effect judging standards:
Cure: gastralgia and other transference cures, x line, canel barium meal contrast examination or gastroscopy are normal.
Taking a turn for the better: stomachache is alleviated, outbreak reduces, other symptoms alleviate.
Not healing: x line, canel barium meal contrast examination or gastroscopy are the same with premorbid, symptom is without improving and taking a turn for the better.
Treatment stomachache 600 example effects
After using 30 days, 600 examples effective 417 examples of stomachache, take a turn for the better 127 examples, invalid 56 examples, obvious effective rate 70%, improvement rate 21%, total effective rate 91%.In use, all user all reflect that appetite improves, appetite increase, and stool form and Color makes moderate progress.

Claims (3)

1. the Chinese medicine composition treating erosive gastritis, it is characterised in that include the raw material of following weight portion: Radix Angelicae Sinensis 3-5, Herba Belladonnae 3-5, Radix Pecteilis susannae 6-8, Herba Asari 1-3, Fructus Caryophylli 6-8, Endothelium Corneum Gigeriae Galli 8-12, Rhizoma Zingiberis 1-3, Herba Cynomorii 1-3.
A kind of Chinese medicine composition treating erosive gastritis the most according to claim 1, it is characterised in that include following heavy The raw material of amount part: Radix Angelicae Sinensis 4, Herba Belladonnae 4, Radix Pecteilis susannae 7, Herba Asari 2, Fructus Caryophylli 7, Endothelium Corneum Gigeriae Galli 10, Rhizoma Zingiberis 2, Herba Cynomorii 2.
The preparation method of a kind of Chinese medicine composition treating erosive gastritis the most according to claim 1 and 2: its feature exists In comprising following process steps: take the Radix Angelicae Sinensis of each weight portion, Herba Belladonnae, Radix Pecteilis susannae, Herba Asari by proportion relation, Fructus Caryophylli, in chicken Gold, Rhizoma Zingiberis, Herba Cynomorii；Add 70% ethanol to soak 15 minutes at 60～65 DEG C, reflux, extract, 2-3 time, each 1 hour, 100 mesh filters Filter, obtain extracting solution；United extraction liquid, recovered under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution；By dense Contracting liquid is spray-dried at 70-100 DEG C or dries, and is ground into the fine powder of 70-100 mesh, Conventional compression or encapsulated after granulation, i.e. ?.
CN201610649137.9A 2016-08-10 2016-08-10 A kind of Chinese medicine composition treating erosive gastritis and preparation method thereof Pending CN106177846A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250871A (en) * 2015-10-14 2016-01-20 王成军 Traditional Chinese medicine composition for treating stomach illness and preparing method thereof
CN105343435A (en) * 2015-12-14 2016-02-24 李建敏 Traditional Chinese medicine composition for curing stomach swelling pain and preparation method thereof
CN105381388A (en) * 2015-12-21 2016-03-09 李建敏 Traditional Chinese medicine composition for treating stomach discomfort and preparing method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250871A (en) * 2015-10-14 2016-01-20 王成军 Traditional Chinese medicine composition for treating stomach illness and preparing method thereof
CN105343435A (en) * 2015-12-14 2016-02-24 李建敏 Traditional Chinese medicine composition for curing stomach swelling pain and preparation method thereof
CN105381388A (en) * 2015-12-21 2016-03-09 李建敏 Traditional Chinese medicine composition for treating stomach discomfort and preparing method thereof

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Application publication date: 20161207