CN106063787A - 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 - Google Patents
拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 Download PDFInfo
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- CN106063787A CN106063787A CN201610357641.1A CN201610357641A CN106063787A CN 106063787 A CN106063787 A CN 106063787A CN 201610357641 A CN201610357641 A CN 201610357641A CN 106063787 A CN106063787 A CN 106063787A
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201261595006P | 2012-02-03 | 2012-02-03 | |
| US61/595,006 | 2012-02-03 | ||
| CN201380007766.6A CN104093310A (zh) | 2012-02-03 | 2013-02-01 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
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| CN201380007766.6A Division CN104093310A (zh) | 2012-02-03 | 2013-02-01 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
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| CN201380007766.6A Pending CN104093310A (zh) | 2012-02-03 | 2013-02-01 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
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| US8178127B2 (en) | 2007-12-20 | 2012-05-15 | Teva Pharmaceuticals Industries, Ltd. | Stable laquinimod preparations |
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| EP2766020A4 (en) | 2011-10-12 | 2015-04-01 | Teva Pharma | TREATMENT OF MULTIPLE SCLEROSIS BY COMBINING LAQUINIMOD AND FINGOLIMOD |
| JP6215238B2 (ja) | 2012-02-16 | 2017-10-18 | テバ ファーマシューティカル インダストリーズ リミティド | Ｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４，５−ジ−ヒドロキシ−１−メチル−２−オキソ−３−キノリンカルボキサミド、その製剤、および使用 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| HK1215210A1 (zh) | 2012-11-07 | 2016-08-19 | Teva Pharmaceutical Industries Ltd. | 拉喹莫德胺盐 |
| US9233927B2 (en) | 2013-03-14 | 2016-01-12 | Teva Pharmaceutical Industries, Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| EP3094330A4 (en) * | 2014-01-17 | 2017-09-27 | Teva Pharmaceutical Industries Ltd | Treatment of crohn's disease using low doses of laquinimod |
| AU2015253330A1 (en) | 2014-04-29 | 2016-12-01 | Teva Pharmaceutical Industries Ltd. | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with a high disability status |
| MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
| CN116672446A (zh) * | 2015-09-17 | 2023-09-01 | 美国安进公司 | 使用il23途径生物标志物预测il23拮抗剂的临床应答 |
| CA3053416A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
| WO2018151873A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| EP3801459B1 (en) | 2018-06-06 | 2024-08-07 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| KR102824401B1 (ko) * | 2018-11-30 | 2025-06-25 | 아레나 파마슈티칼스, 인크. | S1p1 수용체와 관련된 병태의 치료 방법 |
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-
2013
- 2013-02-01 JP JP2014555758A patent/JP2015505564A/ja not_active Withdrawn
- 2013-02-01 AR ARP130100296A patent/AR089862A1/es unknown
- 2013-02-01 TW TW102104087A patent/TW201345527A/zh unknown
- 2013-02-01 CN CN201610357641.1A patent/CN106063787A/zh active Pending
- 2013-02-01 CA CA2862865A patent/CA2862865A1/en not_active Abandoned
- 2013-02-01 BR BR112014018485A patent/BR112014018485A8/pt not_active IP Right Cessation
- 2013-02-01 SG SG11201404214QA patent/SG11201404214QA/en unknown
- 2013-02-01 EA EA201491460A patent/EA201491460A1/ru unknown
- 2013-02-01 KR KR1020147024856A patent/KR20140138694A/ko not_active Withdrawn
- 2013-02-01 AU AU2013214909A patent/AU2013214909A1/en not_active Abandoned
- 2013-02-01 HK HK15103524.2A patent/HK1202776A1/xx unknown
- 2013-02-01 CN CN201380007766.6A patent/CN104093310A/zh active Pending
- 2013-02-01 WO PCT/US2013/024356 patent/WO2013116657A1/en not_active Ceased
- 2013-02-01 US US13/757,004 patent/US9161935B2/en active Active
- 2013-02-01 EP EP13744015.2A patent/EP2811832A4/en not_active Withdrawn
- 2013-02-01 MX MX2014009373A patent/MX2014009373A/es unknown
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2014
- 2014-07-08 IL IL233557A patent/IL233557A0/en unknown
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2015
- 2015-08-25 US US14/835,123 patent/US20150359788A1/en not_active Abandoned
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2017
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- 2017-05-26 JP JP2017104049A patent/JP2017200926A/ja not_active Withdrawn
- 2017-06-26 US US15/633,132 patent/US20170290822A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050234238A1 (en) * | 2002-06-25 | 2005-10-20 | Daniel Dube | 8-(Biaryl)quinoline pde4 inhibitors |
| US20080044382A1 (en) * | 2006-02-28 | 2008-02-21 | Ivan Lieberburg | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| WO2011014255A1 (en) * | 2009-07-30 | 2011-02-03 | Teva Pharmaceutical Industries Ltd. | Treatment of crohn's disease with laquinimod |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017200926A (ja) | 2017-11-09 |
| US9161935B2 (en) | 2015-10-20 |
| US20130203807A1 (en) | 2013-08-08 |
| SG11201404214QA (en) | 2014-08-28 |
| BR112014018485A8 (pt) | 2017-07-11 |
| CN104093310A (zh) | 2014-10-08 |
| EP2811832A1 (en) | 2014-12-17 |
| US20150359788A1 (en) | 2015-12-17 |
| IL233557A0 (en) | 2014-08-31 |
| MX2014009373A (es) | 2014-08-27 |
| TW201345527A (zh) | 2013-11-16 |
| JP2015505564A (ja) | 2015-02-23 |
| KR20140138694A (ko) | 2014-12-04 |
| US20170290822A1 (en) | 2017-10-12 |
| WO2013116657A1 (en) | 2013-08-08 |
| AR089862A1 (es) | 2014-09-24 |
| AU2017200472A1 (en) | 2017-02-09 |
| CA2862865A1 (en) | 2013-08-08 |
| BR112014018485A2 (enExample) | 2017-06-20 |
| EA201491460A1 (ru) | 2015-01-30 |
| HK1202776A1 (en) | 2015-10-09 |
| EP2811832A4 (en) | 2015-09-23 |
| AU2013214909A1 (en) | 2014-09-18 |
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